{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:57Z","timestamp":1784557017711,"version":"3.55.0"},"reference-count":12,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Cushing\u2019s disease or pituitary adrenocorticotropic hormone (ACTH)-dependent Cushing\u2019s syndrome is considered a rare condition. It is caused by hypersecretion of the ACTH by a pituitary adenoma that ultimately induces endogenous hypercortisolism by stimulating the adrenal glands. It is responsible for significant morbidity and mortality. The clinical signs and symptoms of hypercortisolism are usually common and non-specific including obesity, moon face, hypertension, hirsutism and facial plethora. The association between Cushing\u2019s disease and calcinosis cutis which is defined as dystrophic calcium deposition in the skin and subcutaneous tissues is extremely rare. To the best of our knowledge, it has never been described previously in humans, probably like a symptom or complication of chronic and severe hypercortisolism. In this paper, we report a case of a 30-year-old female diagnosed with Cushing\u2019s disease and presented bilateral leg\u2019s calcinosis cutis complicated with ulceration. The evolution was favorable and the complete cicatrization was obtained 12 months following the suppression of systemic glucocorticoid excess.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Calcinosis cutis is common in autoimmune connective diseases. However, to our knowledge, it has never been reported in humans with Cushing\u2019s disease.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Given the rarity of this association, the diagnostic approach to calcinosis cutis must exclude the other etiologies.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Calcinosis cutis is challenging to treat with no gold standard therapy. In our case, the use of the combination of colchicine and bisphosphonates does not significantly improve the patient\u2019s outcomes. In fact, we suppose that without treating the endogenous hypercortisolism, the calcinosis cutis will not resolve.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-21-0113","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:30:00Z","timestamp":1654579800000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["An extremely rare case of calcinosis cutis in human Cushing\u2019s disease"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-3885","authenticated-orcid":true,"given":"Najoua","family":"Rbiai","sequence":"first","affiliation":[{"name":"Department of Diabetology and Endocrinology, Mohammed VI Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Mahroug","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology, Mohammed VI Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Zizi","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology, Clinical Research and Public Health"},{"name":"Department of Dermatology, Mohammed VI Hospital, Faculty of Medicine and Pharmacy, Mohamed Ist University, Oujda, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Latrech","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology, Mohammed VI Hospital"},{"name":"Laboratory of Epidemiology, Clinical Research and Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Best Practice and Research: Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.beem.2009.06.001","article-title":"Cushing\u2019s disease","volume":"23","author":"Bertagna","year":"2009","unstructured":"Bertagna XGuignat LGroussin LBertherat J. Cushing\u2019s disease. Best Practice and Research: Clinical Endocrinology and Metabolism200923607\u2013623. (https:\/\/doi.org\/10.1016\/j.beem.2009.06.001)10.1016\/j.beem.2009.06.001542586"},{"issue":"Supplement 1","key":"bib2","series-title":"Neuroendocrinology","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000314297","article-title":"Epidemiology of Cushing\u2019s syndrome","volume":"92","author":"Steffensen","year":"2010","unstructured":"Steffensen CBak AMRubeck KZJ\u00f8rgensen JO. Epidemiology of Cushing\u2019s syndrome. Neuroendocrinology201092 (Supplement 1) 1\u20135. (https:\/\/doi.org\/10.1159\/000314297)10.1159\/0003142978243099"},{"key":"bib3","series-title":"Quarterly Journal of Medicine","first-page":"465","article-title":"Psychiatric manifestations of Cushing\u2019s syndrome: response to lowering of plasma cortisol","volume":"48","author":"Jeffcoate","year":"1979","unstructured":"Jeffcoate WJSilverstone JTEdwards CRBesser GM. Psychiatric manifestations of Cushing\u2019s syndrome: response to lowering of plasma cortisol. Quarterly Journal of Medicine197948465\u2013472.15777477"},{"key":"bib4","series-title":"Seminars in Arthritis and Rheumatism","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.semarthrit.2005.01.016","article-title":"Calcinosis in rheumatic diseases","volume":"34","author":"Boulman","year":"2005","unstructured":"Boulman NSlobodin GRozenbaum MRosner I. Calcinosis in rheumatic diseases. Seminars in Arthritis and Rheumatism200534805\u2013812. 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(https:\/\/doi.org\/10.1186\/1475-2840-4-4)15777477"},{"key":"bib9","series-title":"British Journal of Dermatology","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1111\/bjd.12785","article-title":"Plain radiography is effective for the detection of calcinosis cutis occurring in association with auto-immune connective tissue disease","volume":"170","author":"Shahi","year":"2014","unstructured":"Shahi VWetter DAHowe BMRingler MDDavis MDP. Plain radiography is effective for the detection of calcinosis cutis occurring in association with auto-immune connective tissue disease. British Journal of Dermatology20141701073\u20131079. (https:\/\/doi.org\/10.1111\/bjd.12785)10.1111\/bjd.12785"},{"key":"bib10","series-title":"Revue Medicale Suisse","first-page":"668","article-title":"Calcinose cutan\u00e9e associ\u00e9e aux connectivites","volume":"11","author":"Fabreguet","year":"2015","unstructured":"Fabreguet ISaurat JHRizzoli RFerrari S. Calcinose cutan\u00e9e associ\u00e9e aux connectivites. Revue Medicale Suisse201511668\u2013672.23565978"},{"key":"bib11","series-title":"Veterinary Dermatology","article-title":"Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases","volume":"24","author":"Doerr","year":"2013","unstructured":"Doerr KAOuterbridge CAWhite SDKass PHShiraki RLam ATAffolter VK. Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases. Veterinary Dermatology201324 355\u2013361. (https:\/\/doi.org\/10.1111\/vde.12026)"},{"key":"bib12","series-title":"Veterinary Radiology and Ultrasound","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1740-8261.1994.tb00170.x","article-title":"Pulmonary mineralization in four dogs with Cushing\u2019s syndrome","volume":"35","author":"Berry","year":"1994","unstructured":"Berry CRAckerman NMonce K. Pulmonary mineralization in four dogs with Cushing\u2019s syndrome. Veterinary Radiology and Ultrasound19943510\u201316. 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