{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:53Z","timestamp":1784557073904,"version":"3.55.0"},"reference-count":9,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"\n Summary<\/jats:title>\n Central diabetes insipidus (CDI) is a rare manifestation of acute myeloid leukemia (AML) with unclear etiology. When present, CDI in AML has most often been described in patients with chromosome 3 or 7 aberrations and no abnormalities on brain imaging. In this case, we present a woman with newly diagnosed AML t(12;14)(p12;q13) found to have diabetes insipidus (DI) with partial anterior pituitary dysfunction and abnormal brain imaging. While in hospital, the patient developed an elevated serum sodium of 151 mmol\/L with a serum osmolality of 323 mmol\/kg and urine osmolality of 154 mmol\/kg. On history, she reported polyuria and polydipsia for 5 months preceding hospitalization. Based on her clinical symptoms and biochemistry, she was diagnosed with DI and treated using intravenous desmopressin with good effect; sodium improved to 144 mmol\/L with a serum osmolality of 302 mmol\/kg and urine osmolality of 501 mmol\/kg. An MRI of the brain done for the assessment of neurologic involvement revealed symmetric high-T2 signal within the hypothalamus extending into the mamillary bodies bilaterally, a partially empty sella, and loss of the pituitary bright spot. A pituitary panel was completed which suggested partial anterior pituitary dysfunction. The patient\u2019s robust improvement with low-dose desmopressin therapy along with her imaging findings indicated a central rather than nephrogenic cause for her DI. Given the time course of her presentation with respect to her AML diagnosis, MRI findings, and investigations excluding other causes, her CDI and partial anterior pituitary dysfunction were suspected to be secondary to hypothalamic leukemic infiltration.<\/jats:p>\n <\/jats:sec>\n \n Learning points<\/jats:title>\n \n \n Leukemic infiltration of the pituitary gland is a rare cause of central diabetes insipidus (CDI) in patients with acute myeloid leukemia (AML).<\/jats:p>\n <\/jats:list-item>\n \n Patients with AML and CDI may compensate for polyuria and prevent hypernatremia with increased water intake.<\/jats:p>\n <\/jats:list-item>\n \n AML-associated CDI can require long-term desmopressin treatment, independent of AML response to treatment.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-21-0153","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T07:46:14Z","timestamp":1658907974000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Central diabetes insipidus and partial anterior pituitary dysfunction in acute myeloid leukemia"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0762-6148","authenticated-orcid":true,"given":"Rigya","family":"Arya","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tehmina","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya","family":"Dash","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Banting and Best Diabetes Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Nature Reviews: Disease Primers","first-page":"54","article-title":"Diabetes insipidus","volume":"5","author":"Christ-Crain","year":"2019","unstructured":"Christ-Crain MBichet DGFenske WKGoldman MBRittig SVerbalis JGVerkman AS. Diabetes insipidus. Nature Reviews: Disease Primers2019554. (https:\/\/doi.org\/10.1038\/s41572-019-0103-2)31395885"},{"key":"bib2","series-title":"Blood Cells, Molecules and Diseases","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bcmd.2019.01.005","article-title":"Acute myeloid leukemia with central diabetes insipidus","volume":"76","author":"Ladigan","year":"2019","unstructured":"Ladigan SMika TFigge AMay AMSchmiegel WSchroers RBaraniskin A. Acute myeloid leukemia with central diabetes insipidus. Blood Cells, Molecules and Diseases20197645\u201352. (https:\/\/doi.org\/10.1016\/j.bcmd.2019.01.005)10.1016\/j.bcmd.2019.01.0053319680"},{"key":"bib3","series-title":"AACE Clinical Case Reports","doi-asserted-by":"publisher","first-page":"e518","DOI":"10.4158\/ACCR-2018-0184","article-title":"Acute myeloid leukemia associated leukocytic hypophysitis presenting with central diabetes insipidus","volume":"4","author":"Levine","year":"2018","unstructured":"Levine JAPariser ABloomgarden E. Acute myeloid leukemia associated leukocytic hypophysitis presenting with central diabetes insipidus. AACE Clinical Case Reports20184e518\u2013e520. (https:\/\/doi.org\/10.4158\/ACCR-2018-0184)10.4158\/ACCR-2018-018433643671"},{"key":"bib4","series-title":"European Journal of Haematology","first-page":"404","article-title":"Monosomy 7 predisposes to diabetes insipidus in leukemia and myelodysplastic syndrome","volume":"39","author":"De La Chapelle","year":"1987","unstructured":"De La Chapelle ALahtinen R. Monosomy 7 predisposes to diabetes insipidus in leukemia and myelodysplastic syndrome. European Journal of Haematology198739404\u2013411. (https:\/\/doi.org\/10.1111\/j.1600-0609.1987.tb01447.x)"},{"key":"bib5","series-title":"Case Reports in Hematology","first-page":"8898671","article-title":"Concurrent central diabetes insipidus and acute myeloid leukemia","volume":"2021","author":"Pritzl","year":"2021","unstructured":"Pritzl SLMatson DRJuckett MBCiske DJ. Concurrent central diabetes insipidus and acute myeloid leukemia. Case Reports in Hematology202120218898671. (https:\/\/doi.org\/10.1155\/2021\/8898671)31395885"},{"key":"bib6","series-title":"Endocrine Practice","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1530-891X(20)47306-9","article-title":"Nephrogenic diabetes insipidus secondary to cytarabine and idarubicin in a patient with acute myelogenous leukemia: a case report","volume":"24","author":"Siddiqui","year":"2018","unstructured":"Siddiqui MFSilverberg AGupta DPrasad A. Nephrogenic diabetes insipidus secondary to cytarabine and idarubicin in a patient with acute myelogenous leukemia: a case report. Endocrine Practice201824181\u2013182. (https:\/\/doi.org\/10.1016\/S1530-891X(2047306-9)10.1016\/S1530-891X(20)47306-93319680"},{"key":"bib7","series-title":"Internal Medicine","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2169\/internalmedicine.49.2697","article-title":"Myelodysplastic syndrome complicated by central diabetes insipidus and cerebral salt wasting syndrome with peculiar changes in magnetic resonance images","volume":"49","author":"Sano","year":"2010","unstructured":"Sano SYamagami KMorikawa TYoshioka K. Myelodysplastic syndrome complicated by central diabetes insipidus and cerebral salt wasting syndrome with peculiar changes in magnetic resonance images. Internal Medicine201049161\u2013165. (https:\/\/doi.org\/10.2169\/internalmedicine.49.2697)10.2169\/internalmedicine.49.269733643671"},{"key":"bib8","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1002\/1097-0142(197109)28:3<666::AID-CNCR2820280322>3.0.CO;2-H","article-title":"Diabetes insipidus as a complication of leukemia: a case report with a literature review","volume":"28","author":"Miller","year":"1971","unstructured":"Miller VICampbell WG. Diabetes insipidus as a complication of leukemia: a case report with a literature review. Cancer197128666\u2013673. (https:\/\/doi.org\/10.1002\/1097-0142(197109)28:3<666::aid-cncr2820280322>3.0.co;2-h)10.1002\/1097-0142(197109)28:3<666::AID-CNCR2820280322>3.0.CO;2-H"},{"key":"bib9","series-title":"Turkish Journal of Neurology","first-page":"77","article-title":"Acute myeloid leukemia with hypothalamic involvement causing central diabetes insipidus","volume":"24","author":"Ufuk","year":"2018","unstructured":"Ufuk FDuran MErt\u00fcrk MS. Acute myeloid leukemia with hypothalamic involvement causing central diabetes insipidus. Turkish Journal of Neurology20182477\u201378. 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