{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:23Z","timestamp":1784557043320,"version":"3.55.0"},"reference-count":13,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Vitamin D intoxication in children is rare but its incidence is increasing as vitamin D is supplemented more often and in higher doses. Children with cystic fibrosis (CF) are at risk for vitamin D intoxication due to incorrect compounded preparations of liposoluble vitamins. Here, we report a severe vitamin D intoxication in a 4-year-old girl with CF, due to an error in the compounded vitamin A, D, E, and K preparation, presenting clinically with weight loss, constipation, polydipsia, polyuria, and nycturia. The administered compounded preparation contained 10 000-fold the prescribed vitamin D dose. The patient was treated with hyperhydration, loop diuretics, and bisphosphonates. Serum calcium levels normalized after 4 days but serum 25-hydroxyvitamin D levels remained elevated even up to 2 months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Vitamin D intoxication should be ruled out when patients with cystic fibrosis (CF) present with acute polyuria, constipation, and weight loss.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Prompt treatment is necessary to avert life-threatening complications.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Regularly measuring serum calcium and 25-hydroxyvitamin D concentrations in children with CF receiving vitamin A, D, E, and K supplements is important during their follow-up.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-21-0181","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T05:11:41Z","timestamp":1644988301000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Everything in excess is opposed to nature, even vitamin D: a case report"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-9126","authenticated-orcid":true,"given":"E","family":"Nauwynck","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Vanbesien","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"De Schepper","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Gies","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Van Leynseele","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, AZ Jan Portaels, Vilvoorde, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"De Wachter","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Hauser","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Staels","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal Brasileiro de Nefrologia","first-page":"213","article-title":"Hypercalcemia in children: three cases report with unusual clinical presentations","volume":"39","author":"Garbim","year":"2017","unstructured":"Garbim BBD\u2019Avila LPinto Rigatto SZRosana da Silva Quadros KSantoro Belangero VMBueno de Oliveira R. 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(https:\/\/doi.org\/10.1210\/jc.2013-3655)10.1210\/jc.2013-3655"},{"key":"bib3","series-title":"Toxicology International","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4103\/0971-6580.172284","article-title":"An unsuspected pharmacological vitamin D toxicity in a child and its brief review of literature","volume":"22","author":"Nimesh","year":"2015","unstructured":"Nimesh MSingh PJhamb UDubey AP. An unsuspected pharmacological vitamin D toxicity in a child and its brief review of literature. Toxicology International201522167\u2013169. (https:\/\/doi.org\/10.4103\/0971-6580.172284)10.4103\/0971-6580.172284"},{"key":"bib4","series-title":"Nutrients","article-title":"Development of vitamin D toxicity from overcorrection of vitamin D deficiency: a review of case reports","volume":"10","author":"Galior","year":"2018","unstructured":"Galior KGrebe SSingh R. Development of vitamin D toxicity from overcorrection of vitamin D deficiency: a review of case reports. Nutrients201810 953. (https:\/\/doi.org\/10.3390\/nu10080953)"},{"key":"bib5","series-title":"Journal of Pediatric Endocrinology and Metabolism","first-page":"763","article-title":"Vitamin D intoxication in two brothers: be careful with dietary supplements","volume":"27","author":"Conti","year":"2014","unstructured":"Conti GChiricco VLacquaniti ASilipigni LFede CVitale AFede C. Vitamin D intoxication in two brothers: be careful with dietary supplements. Journal of Pediatric Endocrinology and Metabolism201427763\u2013767. (https:\/\/doi.org\/10.1515\/jpem-2013-0220)"},{"key":"bib6","series-title":"Scientific Reports","article-title":"Vitamin D intoxication in patients with cystic fibrosis: report of a single center cohort","volume":"11","author":"Plant\u00e9-Bordeneuve","year":"2021","unstructured":"Plant\u00e9-Bordeneuve TBerardis SBastin PGruson DHenri LGohy S. Vitamin D intoxication in patients with cystic fibrosis: report of a single center cohort. Scientific Reports202111 7719. (https:\/\/doi.org\/10.1038\/s41598-021-87099-w)"},{"key":"bib7","series-title":"Journal of Clinical Research in Pediatric Endocrinology","doi-asserted-by":"publisher","first-page":"140","DOI":"10.4274\/jcrpe.galenos.2018.2018.0131","article-title":"Comparison of treatment regimens in management of severe hypercalcemia due to vitamin D intoxication in children","volume":"11","author":"Demir","year":"2019","unstructured":"Demir KD\u00f6neray HKara CAtay ZCetinkaya SCayir AAnik AEren EU\u00e7akt\u00fcrk ACan Y\u0131lmaz GComparison of treatment regimens in management of severe hypercalcemia due to vitamin D intoxication in children. Journal of Clinical Research in Pediatric Endocrinology201911140\u2013148. 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European Journal of Endocrinology2019181R11\u2013R21. (https:\/\/doi.org\/10.1530\/EJE-19-0163)10.1530\/EJE-19-0163"},{"key":"bib10","series-title":"Journal of Clinical Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1210\/jc.2002-020978","article-title":"Body fat content and 25-hyrdroxyvitamin D levels in healthy women","volume":"88","author":"Arunabh","year":"2003","unstructured":"Arunabh SPollack SYeh JAloia JF. Body fat content and 25-hyrdroxyvitamin D levels in healthy women. Journal of Clinical Endocrinology and Metabolism200388157\u2013161. 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Pediatrics2014133e240\u2013e244. (https:\/\/doi.org\/10.1542\/peds.2013-0711)10.1542\/peds.2013-0711"},{"key":"bib13","series-title":"Journal of Paediatrics and Child Health","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/jpc.13768","article-title":"Consensus guidelines on the use of bisphosphonate therapy in children and adolescents","volume":"54","author":"Simm","year":"2018","unstructured":"Simm PJBiggin AZacharin MRRodda CPTham ESiafarikas AJefferies CHofman PLJensen DEWoodhead HConsensus guidelines on the use of bisphosphonate therapy in children and adolescents. Journal of Paediatrics and Child Health201854223\u2013233. 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