{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:48Z","timestamp":1784557068185,"version":"3.55.0"},"reference-count":19,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHP) is the most common aetiology for hypercalcaemia. The incidence of PHP in pregnant women is reported to be 8\/100 000 population\/year. It presents a threat to the health of both mother (hyperemesis, nephrolithiasis) and fetus (fetal death, congenital malformations, and neonatal severe hypocalcaemia-induced tetany). However, there is a lack of clear guidance on the management of primary hyperparathyroidism in pregnancy. In this study, we describe the case of a 26-year-old female patient who presented with severe hypercalcaemia secondary to PHP and underwent successful parathyroid adenectomy under local anaesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Primary hyperparathyroidism is a rare complication in pregnancy, but the consequences for mother and fetus can be severe.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>A perceived risk of general anaesthesia to the fetus in the first trimester has resulted in a general consensus to delay parathyroid surgery to the second trimester when possible \u2013 although the increased risk of fetal loss may occur before planned surgery.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>If the patient presents with severe or symptomatic hypercalcaemia, minimally invasive surgery under local anaesthetic should be considered regardless of the gestational age of the pregnancy.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-21-0203","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T14:14:10Z","timestamp":1662560050000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Management of severe and symptomatic primary hyperparathyroidism in the first trimester of unplanned pregnancy"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-4068","authenticated-orcid":true,"given":"Adele J","family":"Beck","sequence":"first","affiliation":[{"name":"Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkat M","family":"Reddy","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospitals NHS Trust, Endocrinology and Diabetes Mellitus, Treliske, Truro, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Sulkin","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospitals NHS Trust, Endocrinology and Diabetes Mellitus, Treliske, Truro, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Browne","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospitals NHS Trust, Endocrinology and Diabetes Mellitus, Treliske, Truro, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Case Reports in Endocrinology","first-page":"520516","article-title":"Primary hyperparathyroidism in pregnancy \u2013 a rare cause of life-threatening hypercalcaemia: case report and literature review","volume":"2011","author":"Malekar-Raikar","year":"2011","unstructured":"Malekar-Raikar SSinnott BP. 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