{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:53Z","timestamp":1784557073879,"version":"3.55.0"},"reference-count":7,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"\n Summary<\/jats:title>\n Increased intracranial pressure (ICP) can present with symptoms of headache, vomiting, visual changes, and tinnitus. Papilledema may be seen on physical exam. Thyroid disease has been a rare secondary cause of increased ICP. We present a 16-year-old female who had a worsening headache for 6 months. She was found to have signs, symptoms, physical exam findings, and diagnostic studies consistent with both increased ICP and previously undiagnosed Graves\u2019 disease. The patient was treated with a 19-month course of methimazole 40 mg daily. Her headache and papilledema resolved shortly after medication initiation. The timeline of symptoms and resolution of her increased ICP symptoms with treatment of Graves\u2019 disease suggests that hyperthyroidism was the underlying cause of her increased ICP. Clinicians should consider Graves\u2019 disease as the etiology in pediatric patients presenting with signs and symptoms of increased ICP with papilledema.<\/jats:p>\n <\/jats:sec>\n \n Learning points<\/jats:title>\n \n \n Symptoms of increased intracranial pressure (ICP) include headache, vomiting, transient visual changes, and tinnitus.<\/jats:p>\n <\/jats:list-item>\n \n Secondary causes of increased ICP should be considered in males, young children, older patients, and those not overweight.<\/jats:p>\n <\/jats:list-item>\n \n Clinicians should consider Graves\u2019 disease as the etiology in pediatric patients presenting with signs and symptoms of increased ICP with papilledema. They should assess for orbitopathy and thyromegaly and inquire about symptoms that would be indicative of hyperthyroidism.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-22-0240","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T04:38:24Z","timestamp":1650861504000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Graves\u2019 disease in an adolescent presenting with increased intracranial pressure and bilateral papilledema"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-0279","authenticated-orcid":true,"given":"Jay","family":"Nguyen","sequence":"first","affiliation":[{"name":"Lincoln Memorial University-DeBusk College of Osteopathic Medicine, Harrogate, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-9909","authenticated-orcid":true,"given":"Dennis","family":"Joseph","sequence":"additional","affiliation":[{"name":"Endocrinology Center of Lake Cumberland, Somerset, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Neuro-Ophthalmology","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/00041327-200406000-00009","article-title":"Idiopathic intracranial hypertension","volume":"24","author":"Friedman","year":"2004","unstructured":"Friedman DIJacobson DM. Idiopathic intracranial hypertension. Journal of Neuro-Ophthalmology200424138\u2013145. (https:\/\/doi.org\/10.1097\/00041327-200406000-00009)10.1097\/00041327-200406000-00009"},{"key":"bib2","series-title":"Survey of Ophthalmology","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0039-6257(92)90134-F","article-title":"Pediatric pseudotumor cerebri (idiopathic intracranial hypertension)","volume":"37","author":"Lessell","year":"1992","unstructured":"Lessell SPediatric pseudotumor cerebri (idiopathic intracranial hypertension). Survey of Ophthalmology199237155\u2013166. (https:\/\/doi.org\/10.1016\/0039-6257(9290134-f)10.1016\/0039-6257(92)90134-F"},{"key":"bib3","series-title":"Journal of Medical Case Reports","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1752-1947-5-68","article-title":"Graves\u2019 disease presenting as pseudotumor cerebri: a case report","volume":"5","author":"Coutinho","year":"2011","unstructured":"Coutinho ESilva AMFreitas CSantos E. Graves\u2019 disease presenting as pseudotumor cerebri: a case report. Journal of Medical Case Reports2011568. (https:\/\/doi.org\/10.1186\/1752-1947-5-68)10.1186\/1752-1947-5-68"},{"key":"bib4","series-title":"Hormone Research in Paediatrics","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1159\/000321180","article-title":"Pediatric idiopathic intracranial hypertension (pseudotumor cerebri)","volume":"74","author":"Ko","year":"2010","unstructured":"Ko MWLiu GT. Pediatric idiopathic intracranial hypertension (pseudotumor cerebri). Hormone Research in Paediatrics201074381\u2013389. (https:\/\/doi.org\/10.1159\/000321180)10.1159\/000321180"},{"key":"bib5","series-title":"International Journal of Case Reports and Images","doi-asserted-by":"publisher","first-page":"702","DOI":"10.5348\/ijcri-2013-12-415-CR-9","article-title":"Pseudotumor cerebri caused by uncontrolled Graves\u2019 disease in an adolescent","volume":"4","author":"Kumar","year":"2013","unstructured":"Kumar AKilaikode SSaenger P. Pseudotumor cerebri caused by uncontrolled Graves\u2019 disease in an adolescent. International Journal of Case Reports and Images20134702\u2013704. (https:\/\/doi.org\/10.5348\/ijcri-2013-12-415-CR-9)10.5348\/ijcri-2013-12-415-CR-9"},{"key":"bib6","series-title":"Medical Journal of Dr. DY Patil University","doi-asserted-by":"publisher","first-page":"290","DOI":"10.4103\/0975-2870.206574","article-title":"Graves\u2019 disease and idiopathic intracranial hypertension","volume":"10","author":"Gutch","year":"2017","unstructured":"Gutch MBhattarcharjee AKumar SPushkar D. Graves\u2019 disease and idiopathic intracranial hypertension. Medical Journal of Dr. DY Patil University201710290\u2013292. (https:\/\/doi.org\/10.4103\/0975-2870.206574)10.4103\/0975-2870.206574"},{"key":"bib7","series-title":"Autoimmunity Reviews","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.autrev.2014.01.013","article-title":"Diagnosis and classification of Graves\u2019 disease","volume":"13","author":"Menconi","year":"2014","unstructured":"Menconi FMarcocci CMarin\u00f2 M. Diagnosis and classification of Graves\u2019 disease. 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