{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:48Z","timestamp":1784557068218,"version":"3.55.0"},"reference-count":6,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"\n Summary<\/jats:title>\n Skeletal abnormalities with delayed bone age and decreased linear bone growth are commonly found in children with prolonged juvenile hypothyroidism. However, rachitic bone abnormalities have not been previously reported in children with acquired hypothyroidism. Here, we present a case of newly found rickets in an 8-year-old female with untreated acquired hypothyroidism secondary to Hashimoto\u2019s thyroiditis. Laboratory finding for abnormalities in calcium\/phosphorus homeostasis and hormones that regulate skeletal health was normal. Her radiographic anomalies resolved with levothyroxine treatment alone, suggesting that hypothyroidism was the etiology of the rickets. To our knowledge, this is the first case report of rickets associated with long-standing severe acquired hypothyroidism that resolved exclusively with thyroid repletion.<\/jats:p>\n <\/jats:sec>\n \n Learning points<\/jats:title>\n \n \n Thyroid hormone plays an important role in bone mineralization.<\/jats:p>\n <\/jats:list-item>\n \n Prolonged hypothyroidism can result in rachitic bone abnormalities noted on radiographs.<\/jats:p>\n <\/jats:list-item>\n \n Hypothyroidism should be considered in the evaluation of a child with rickets.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-22-0267","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T04:52:28Z","timestamp":1660798348000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto\u2019s thyroiditis"],"prefix":"10.1530","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-5308","authenticated-orcid":true,"given":"Caroline","family":"Schulmeister","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology, University of California at San Francisco, San Francisco, California, USA"},{"name":"Pediatric Endocrinology, University of California at Davis, Sacramento, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lee","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, University of California at San Francisco, San Francisco, California, USA"},{"name":"Pediatric Nephrology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Perwad","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, University of California at San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Long","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, University of California at San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shylaja","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, University of California at San Francisco, San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"New England Journal of Medicine","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1056\/NEJM198803103181003","article-title":"Long-term growth in juvenile acquired hypothyroidism: the failure to achieve normal adult stature","volume":"318","author":"Rivkees","year":"1988","unstructured":"Rivkees SABode HHCrawford JD. Long-term growth in juvenile acquired hypothyroidism: the failure to achieve normal adult stature. New England Journal of Medicine1988318599\u2013602. (https:\/\/doi.org\/10.1056\/NEJM198803103181003)10.1056\/NEJM198803103181003"},{"key":"bib6","series-title":"Endocrine Reviews","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1210\/er.2015-1106","article-title":"Role of thyroid hormones in skeletal development and bone maintenance","volume":"37","author":"Duncan Bassett","year":"2016","unstructured":"Duncan Bassett JHWilliams GR. Role of thyroid hormones in skeletal development and bone maintenance. Endocrine Reviews201637135\u2013187. (https:\/\/doi.org\/10.1210\/er.2015-1106)10.1210\/er.2015-1106"},{"key":"bib7","series-title":"Archives of Biochemistry and Biophysics","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.abb.2010.06.021","article-title":"Thyroid and bone","volume":"503","author":"Gogakos","year":"2010","unstructured":"Gogakos AIDuncan Bassett JHWilliams GR. Thyroid and bone. Archives of Biochemistry and Biophysics2010503129\u2013136. (https:\/\/doi.org\/10.1016\/j.abb.2010.06.021)10.1016\/j.abb.2010.06.021"},{"key":"bib8","series-title":"Orphanet Journal of Rare Diseases","article-title":"Congenital hypothyroidism","volume":"5","author":"Rastogi","year":"2010","unstructured":"Rastogi MVLaFranchi SH. Congenital hypothyroidism. Orphanet Journal of Rare Diseases20105 17. (https:\/\/doi.org\/10.1186\/1750-1172-5-17)"},{"key":"bib9","series-title":"European Journal of Medical Genetics","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ejmg.2007.02.002","article-title":"Severe skeletal dysplasia caused by undiagnosed hypothyroidism","volume":"50","author":"H\u00fcffmeier","year":"2007","unstructured":"H\u00fcffmeier UTietze HURauch A. Severe skeletal dysplasia caused by undiagnosed hypothyroidism. European Journal of Medical Genetics200750209\u2013215. (https:\/\/doi.org\/10.1016\/j.ejmg.2007.02.002)10.1016\/j.ejmg.2007.02.002"},{"key":"bib10","series-title":"Postgraduate Medical Journal","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1136\/pgmj.65.763.312","article-title":"Hypothyroidism and unusual rickets in a very preterm infant","volume":"65","author":"Macmahon","year":"1989","unstructured":"Macmahon PBlair MKovar I. Hypothyroidism and unusual rickets in a very preterm infant. Postgraduate Medical Journal198965312\u2013315. (https:\/\/doi.org\/10.1136\/pgmj.65.763.312)10.1136\/pgmj.65.763.312"}],"container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2022\/1\/EDM22-0267.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2022\/1\/EDM22-0267.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2022\/1\/EDM22-0267.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:47:56Z","timestamp":1784555276000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":6,"URL":"https:\/\/doi.org\/10.1530\/edm-22-0267","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,1]]}}}