{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:26Z","timestamp":1784557046154,"version":"3.55.0"},"reference-count":8,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Calciphylaxis is a rare disorder characterised by the development of painful necrotic skin lesions. Occlusion of cutaneous arterioles due to ectopic calcification leads to potentially life-threatening widespread skin loss. Most cases occur in patients with chronic renal disease, which leads to dysregulation of calcium and phosphate homeostasis. Only a handful of case reports exist describing calciphylaxis occurring in patients without chronic renal disease but with hypoparathyroidism. We report on a unique case of a 53-year-old man with multiple endocrine neoplasia type 1 syndrome and acquired hypoparathyroidism due to total parathyroidectomy who went on to develop calciphylaxis following cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Calciphylaxis most commonly occurs in the context of chronic renal disease but can rarely occur in its absence as a consequence of calcium and phosphate dysregulation.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Patients who develop necrotic skin lesions in the presence of hypoparathyroidism require an urgent dermatological opinion.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Mortality from calciphylaxis is high, with the majority of deaths occurring secondary to sepsis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Management of calciphylaxis requires a multidisciplinary team approach to manage wound healing, infections and pain.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Recovery with full rehabilitation from calciphylaxis can take months to years.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-23-0009","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T06:40:22Z","timestamp":1702017622000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["Calciphylaxis in a patient with hypoparathyroidism and MEN-1 syndrome"],"prefix":"10.1530","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-9828","authenticated-orcid":true,"given":"Isabelle","family":"van Heeswijk","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University Hospitals Derby & Burton NHS Trust, Derby, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Ugur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospitals Derby & Burton NHS Trust, Derby, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynsey","family":"Havill","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospitals Derby & Burton NHS Trust, Derby, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Kinton","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospitals Derby & Burton NHS Trust, Derby, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0994-1977","authenticated-orcid":true,"given":"David","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospitals Derby & Burton NHS Trust, Derby, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of the American Academy of Dermatology","first-page":"569","article-title":"Calciphylaxis: natural history, risk factor analysis, and outcome","volume":"56","author":"Weenig","year":"2007","unstructured":"Weenig RHSewell LDDavis MDPMcCarthy JT & Pittelkow MR. Calciphylaxis: natural history, risk factor analysis, and outcome. Journal of the American Academy of Dermatology200756569\u2013579. (https:\/\/doi.org\/10.1016\/j.jaad.2006.08.065)"},{"issue":"Supplement 3","key":"bib2","series-title":"American Journal of Kidney Diseases","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","year":"2003","unstructured":"National Kidney Foundation. K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. American Journal of Kidney Diseases200342(Supplement 3) S1\u2013S201."},{"key":"bib3","series-title":"Kidney International Reports","first-page":"231","article-title":"Treatment of calciphylaxis in CKD: a systematic review and meta-analysis","volume":"4","author":"Udomkarnjananun","year":"2019","unstructured":"Udomkarnjananun SKongnatthasate KPraditpornsilpa KEiam-Ong SJaber BL & Susantitaphong P. Treatment of calciphylaxis in CKD: a systematic review and meta-analysis. Kidney International Reports20194231\u2013244. (https:\/\/doi.org\/10.1016\/j.ekir.2018.10.002)"},{"key":"bib4","series-title":"Current Opinion in Nephrology and Hypertension","first-page":"276","article-title":"Calciphylaxis","volume":"26","author":"Nigwekar","year":"2017","unstructured":"Nigwekar SU. Calciphylaxis. Current Opinion in Nephrology and Hypertension201726276\u2013281. (https:\/\/doi.org\/10.1097\/MNH.0000000000000328)"},{"key":"bib5","series-title":"JAMA Dermatology","first-page":"251","article-title":"Demographics, comorbid conditions, and outcomes of patients with nonuremic calciphylaxis","volume":"155","author":"Altman","year":"2019","unstructured":"Altman K & Shinohara M. Demographics, comorbid conditions, and outcomes of patients with nonuremic calciphylaxis. JAMA Dermatology2019155251\u2013252. (https:\/\/doi.org\/10.1001\/jamadermatol.2018.4937)"},{"key":"bib6","series-title":"Endocrine Practice","first-page":"e102","article-title":"A case of calciphylaxis in a patient with hypoparathyroidism and normal renal function","volume":"20","author":"Erdel","year":"2014","unstructured":"Erdel BLJuneja R & Evans-Molina C. A case of calciphylaxis in a patient with hypoparathyroidism and normal renal function. Endocrine Practice201420e102\u2013e105. (https:\/\/doi.org\/10.4158\/EP13509.CR)"},{"key":"bib7","series-title":"Journal of Nephrology","first-page":"1537","article-title":"Calciphylaxis in end-stage kidney disease: outcome data from the United Kingdom Calciphylaxis Study","volume":"34","author":"Chinnadurai","year":"2021","unstructured":"Chinnadurai RHuckle AHegarty JKalra PA & Sinha S. Calciphylaxis in end-stage kidney disease: outcome data from the United Kingdom Calciphylaxis Study. Journal of Nephrology2021341537\u20131545. (https:\/\/doi.org\/10.1007\/s40620-020-00908-9)"},{"key":"bib8","series-title":"Cureus","first-page":"e15014","article-title":"Non-uremic calciphylaxis: an unexpected complication with recombinant human parathyroid hormone","volume":"13","author":"DeClue","year":"2021","unstructured":"DeClue CChinnakotla B & Gardner MJ. Non-uremic calciphylaxis: an unexpected complication with recombinant human parathyroid hormone. Cureus202113e15014. 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