{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:26Z","timestamp":1784557046143,"version":"3.55.0"},"reference-count":10,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>A 59-year-old male presented with an accidental thyroid mass in 2022. Ultrasound and CT scan showed a nodule 5.2 \u00d7 4.9 \u00d7 2.8 cm (EU-TIRADS 4) in the right lobe of the thyroid gland. Taking into account the results of the fine needle aspiration biopsy (Bethesda V), intrathyroid localization, and absence of clinical symptoms, a malignant tumor of the thyroid gland was suspected. The patient underwent total thyroidectomy using fluorescence angiography with indocyanine green, and two pairs of intact parathyroid glands were visualized in typical localization. Unexpected histological and immunohistochemistry examinations revealed parathyroid carcinoma. Due to the asymptomatic course of the disease and atypical localization of parathyroid tumor, primary hyperparathyroidism was not suspected before the surgery. The diagnosis of asymptomatic intrathyroid parathyroid cancer is a serious diagnostic challenge for a wide range of specialists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Parathyroid cancer is a rare disease that may be asymptomatic.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Intrathyroidal localization of parathyroid carcinoma is casuistic and challenging for diagnosis, and the treatment strategy is not well defined.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Preoperative parathyroid hormone and serum calcium testing are recommended for patients with solid thyroid nodules (Bethesda IV\u2013V).<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-23-0027","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T09:51:47Z","timestamp":1684144307000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":5,"title":["Silent intrathyroid parathyroid carcinoma"],"prefix":"10.1530","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-8495","authenticated-orcid":true,"given":"Ekaterina","family":"Kim","sequence":"first","affiliation":[{"name":"Endocrinology Research Centre, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Eremkina","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Nikiforovich","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mokrysheva","sequence":"additional","affiliation":[{"name":"Endocrinology Research Centre, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Lancet","first-page":"145","article-title":"Hyperparathyroidism","volume":"374","author":"Fraser","year":"2009","unstructured":"Fraser WD. Hyperparathyroidism. Lancet2009374145\u2013158. (https:\/\/doi.org\/10.1016\/S0140-6736(0960507-9)"},{"key":"bib2","series-title":"Journal of Bone and Mineral Metabolism","first-page":"253","article-title":"Progressive rise in the prevalence of asymptomatic primary hyperparathyroidism in India: data from PHPT registry","volume":"39","author":"Arya","year":"2021","unstructured":"Arya AKKumari PBhadada SKAgrawal KSingh PMukherjee SSood A & Rao SD. Progressive rise in the prevalence of asymptomatic primary hyperparathyroidism in India: data from PHPT registry. Journal of Bone and Mineral Metabolism202139253\u2013259. (https:\/\/doi.org\/10.1007\/s00774-020-01142-w)"},{"key":"bib3","series-title":"Endocrine Surgery","first-page":"178","article-title":"Parathyroid glands: the normal development, anatomy and histological structure","volume":"12","author":"Mokrysheva","year":"2018","unstructured":"Mokrysheva NGKrupinova JA & Voronkova IA. Parathyroid glands: the normal development, anatomy and histological structure. Endocrine Surgery201812178\u2013187. (https:\/\/doi.org\/10.14341\/serg10039)"},{"key":"bib4","series-title":"Medicina","article-title":"Major clues and pitfalls in the differential diagnosis of parathyroid and thyroid lesions using fine needle aspiration cytology","volume":"56","author":"Ha","year":"2020","unstructured":"Ha HJKim EJKim JSShin MSNoh IPark SKoh JS & Lee SS. Major clues and pitfalls in the differential diagnosis of parathyroid and thyroid lesions using fine needle aspiration cytology. Medicina202056 558. (https:\/\/doi.org\/10.3390\/medicina56110558)"},{"key":"bib5","series-title":"Radiation Oncology Journal","first-page":"145","article-title":"Intrathyroidal parathyroid carcinoma: a case report and literature review","volume":"39","author":"Benali","year":"2021","unstructured":"Benali KAarab JBenmessaoud HNourreddine AMajjaoui SEKacemi HEKebdani T & Benjaafar N. Intrathyroidal parathyroid carcinoma: a case report and literature review. Radiation Oncology Journal202139145\u2013151. (https:\/\/doi.org\/10.3857\/roj.2020.01060)"},{"key":"bib6","series-title":"Diagnostic Cytopathology","first-page":"47","article-title":"Cytological challenges in the diagnosis of intrathyroidal parathyroid carcinoma: A case report and review of literature","volume":"46","author":"Balakrishnan","year":"2018","unstructured":"Balakrishnan MGeorge SARajab SHFrancis IM & Kapila K. Cytological challenges in the diagnosis of intrathyroidal parathyroid carcinoma: A case report and review of literature. Diagnostic Cytopathology20184647\u201352. (https:\/\/doi.org\/10.1002\/dc.23847)"},{"key":"bib7","series-title":"Gland Surgery","first-page":"211","article-title":"Parathyroid carcinoma: a silent presentation","volume":"3","author":"Kolluri","year":"2014","unstructured":"Kolluri SLal KChang R & Mandava N. Parathyroid carcinoma: a silent presentation. Gland Surgery20143211\u2013214. (https:\/\/doi.org\/10.3978\/j.issn.2227-684X.2014.07.02)"},{"key":"bib8","series-title":"In Vivo","first-page":"23","article-title":"Intraoperative indocyanine green (ICG) angiography for the identification of the parathyroid glands: current evidence and future perspectives","volume":"34","author":"Spartalis","year":"2020","unstructured":"Spartalis ENtokos GGeorgiou KZografos GTsourouflis GDimitroulis D & Nikiteas NI. Intraoperative indocyanine green (ICG) angiography for the identification of the parathyroid glands: current evidence and future perspectives. In Vivo20203423\u201332. (https:\/\/doi.org\/10.21873\/invivo.11741)"},{"key":"bib9","series-title":"Endocrine Pathology","first-page":"64","article-title":"Overview of the 2022 WHO classification of parathyroid tumors","volume":"33","author":"Erickson","year":"2022","unstructured":"Erickson LAMete OJuhlin CCPerren A & Gill AJ. Overview of the 2022 WHO classification of parathyroid tumors. Endocrine Pathology20223364\u201389. (https:\/\/doi.org\/10.1007\/s12022-022-09709-1)"},{"key":"bib10","series-title":"Frontiers in Endocrinology (Lausanne)","article-title":"Genetics and epigenetics of parathyroid carcinoma","volume":"13","author":"Marini","year":"2022","unstructured":"Marini FGiusti FPalmini GPerigli GSantoro R & Brandi ML. Genetics and epigenetics of parathyroid carcinoma. Frontiers in Endocrinology (Lausanne)202213 834362. 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