{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:43:59Z","timestamp":1785548639691,"version":"3.56.0"},"reference-count":10,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"\n Summary<\/jats:title>\n Myxoedema coma is a severe form of hypothyroidism with multiple organ dysfunction, characterised by an altered state of consciousness and hypothermia. Intravenous thyroid hormone replacement therapy is the preferred treatment for myxoedema. The mortality rate associated with this disease is high, and early detection and intervention are essential. Supraglottal myxoedema is a rare form of periglottic oedema and can be fatal. A previously healthy 66-year-old man presented with impaired consciousness, hypothermia, and nonpitting oedema. Blood tests revealed the presence of hypothyroidism and respiratory acidosis. He was intubated for type 2 respiratory failure; however, severe laryngeal oedema made the procedure difficult to perform. Oral thyroid hormone therapy was initiated under the diagnosis of myxoedema coma. Tracheostomy was performed because of prolonged type 2 respiratory failure and laryngeal oedema. Three weeks after admission, the patient was weaned off the ventilator. Approximately a week later, laryngeal oedema improved, and the tracheostomy tube was removed. The patient was discharged and remained stable for 3 months. This case report describes a patient with comatose myxoedema and supraglottic oedema who was successfully treated with oral medication alone. This case shows that supraglottic oedema should be considered even in the absence of wheezing or other signs of upper airway obstruction.<\/jats:p>\n <\/jats:sec>\n \n Learning points<\/jats:title>\n \n \n Myxoedema coma is a differential diagnosis of respiratory acidosis.<\/jats:p>\n <\/jats:list-item>\n \n In myxoedematous coma, the possibility of difficult intubation due to supraglottic oedema should be considered.<\/jats:p>\n <\/jats:list-item>\n \n Tracheostomy should be considered for supraglottic myxoedema, which often results in prolonged ventilator use.<\/jats:p>\n <\/jats:list-item>\n \n Supraglottic myxoedema can be treated with oral medications.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-23-0078","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T07:56:00Z","timestamp":1708329360000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Supraglottic myxoedema successfully treated orally"],"prefix":"10.1530","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9373-2828","authenticated-orcid":true,"given":"Yu","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Family & General Medicine, Tokyo-Kita Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6005-0520","authenticated-orcid":true,"given":"Satoru","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Family & General Medicine, Tokyo-Kita Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiju","family":"Miyagami","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narumi","family":"Sue","sequence":"additional","affiliation":[{"name":"Department of Family & General Medicine, Tokyo-Kita Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Kainaga","sequence":"additional","affiliation":[{"name":"Department of Family & General Medicine, Tokyo-Kita Medical Center, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Medical Clinics of North America","first-page":"385","article-title":"Thyroid emergencies","volume":"96","author":"Klubo-Gwiezdzinska","year":"2012","unstructured":"Klubo-Gwiezdzinska J & Wartofsky L. 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