{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:00Z","timestamp":1784557020637,"version":"3.55.0"},"reference-count":16,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Primary hypophysitis is a rare disease that may have variable clinical presentations. The main treatment options are clinical observation, immunosuppressive drugs, and surgery. Glucocorticoids are used as first-line medical therapy; however, non-responsiveness and recurrences are the major problems. We present a 30-year-old male patient who had an excellent radiologic response to a single course of glucocorticoids. The patient presented with malaise and severe headaches of acute onset. Cranial MRI revealed a pituitary mass compressing the optic chiasm. Hormonal evaluation studies were consistent with anterior pituitary hormone dysfunction except for the growth hormone axis. There was a mild compression on the optic chiasm in the pituitary MRI. The patient was started on methylprednisolone therapy at a dose of 80 mg\/day. The pituitary MRI revealed complete regression of the mass after 2 months, and there was a complete recovery of pituitary functions after 6 months. There is no consensus on the optimal dose and duration of glucocorticoid therapy for primary hypophysitis in the literature. We report that steroid therapy, even in lower doses, might be effective in mild-to-moderate cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>Primary hypophysitis is a rare disease with a varied clinical course, and hence the treatment strategies should be individualized.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>There is no consensus on the optimal dose and duration of glucocorticoid therapy.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Glucocorticoid therapy may induce complete remission in some patients, especially with a mild-to-moderate disease course and during the acute phase of the disease.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-23-0125","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T05:59:51Z","timestamp":1728280791000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["Complete remission after glucocorticoid therapy in a patient with primary hypophysitis"],"prefix":"10.1530","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6197-5659","authenticated-orcid":true,"given":"Aysa","family":"Hacioglu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gazanfer","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yeditepe University Medical School, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleyha","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"T\u00fcre","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yeditepe University Medical School, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-4683","authenticated-orcid":true,"given":"Fahrettin","family":"Kelestimur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Yeditepe University Medical School, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"10","article-title":"Hypophysitis, the growi","volume":"107","author":"Langlois","year":"2022","unstructured":"Langlois FVarlamov EV & Fleseriu M. Hypophysitis, the growing spectrum of a rare pituitary disease. Journal of Clinical Endocrinology and Metabolism202210710\u201328. (https:\/\/doi.org\/10.1210\/clinem\/dgab672)"},{"key":"bib2","series-title":"Presse Medicale","first-page":"104076","article-title":"Hypophysitis: a comprehensive overview","volume":"50","author":"de Vries","year":"2021","unstructured":"de Vries Fvan Furth WRBiermasz NR & Pereira AM. Hypophysitis: a comprehensive overview. Presse Medicale202150104076. (https:\/\/doi.org\/10.1016\/j.lpm.2021.104076)"},{"key":"bib3","series-title":"Minerva Endocrinologica","first-page":"390","article-title":"The management of hypophysitis","volume":"41","author":"Karaca","year":"2016","unstructured":"Karaca Z & Kelestimur F. The management of hypophysitis. Minerva Endocrinologica201641390\u2013399."},{"key":"bib4","series-title":"Neuroendocrinology","first-page":"822","article-title":"Hypophysitis (including IgG4 and immunotherapy)","volume":"110","author":"Angelousi","year":"2020","unstructured":"Angelousi AAlexandraki KTsoli MKaltsas G & Kassi E. Hypophysitis (including IgG4 and immunotherapy). Neuroendocrinology2020110822\u2013835. (https:\/\/doi.org\/10.1159\/000506903)"},{"key":"bib5","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3460","article-title":"Treatment of primary hypophysitis in Germany","volume":"100","author":"Honegger","year":"2015","unstructured":"Honegger JBuchfelder MSchlaffer SDroste MWerner SStrasburger CStormann SSchopohl JKacheva SDeutschbein T, et al.Treatment of primary hypophysitis in Germany. Journal of Clinical Endocrinology and Metabolism20151003460\u20133469. (https:\/\/doi.org\/10.1210\/jc.2015-2146)"},{"key":"bib6","series-title":"Best Practice and Research. Clinical Endocrinology and Metabolism","first-page":"101371","article-title":"Hypophysitis: an update on the novel forms, diagnosis and management of disorders of pituitary inflammation","volume":"33","author":"Gubbi","year":"2019","unstructured":"Gubbi SHannah-Shmouni FVerbalis JG & Koch CA. Hypophysitis: an update on the novel forms, diagnosis and management of disorders of pituitary inflammation. Best Practice and Research. Clinical Endocrinology and Metabolism201933101371. (https:\/\/doi.org\/10.1016\/j.beem.2019.101371)"},{"key":"bib7","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"1170","article-title":"Outcomes of initial management strategies in patients with autoimmune lymphocytic hypophysitis: a systematic review and meta-analysis","volume":"107","author":"Donegan","year":"2022","unstructured":"Donegan DSaeed ZDelivanis DAMurad MHHonegger JAmereller FOguz SHErickson D & Bancos I. 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(https:\/\/doi.org\/10.1210\/jc.2018-01021)"},{"key":"bib9","series-title":"Endocrine Connections","first-page":"e220311","article-title":"Glucocorticoid therapy as first-line treatment in primary hypophysitis: a systematic review and individual patient data meta-analysis","volume":"12","author":"Krishnappa","year":"2023","unstructured":"Krishnappa BShah RMemon SSDiwaker CLila ARPatil VAShah NS & Bandgar TR. Glucocorticoid therapy as first-line treatment in primary hypophysitis: a systematic review and individual patient data meta-analysis. Endocrine Connections202312e220311. (https:\/\/doi.org\/10.1530\/EC-22-0311)"},{"key":"bib10","series-title":"European Journal of Endocrinology","first-page":"127","article-title":"Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis","volume":"177","author":"Lupi","year":"2017","unstructured":"Lupi ICosottini MCaturegli PManetti LUrbani CCappellani DScattina IMartino EMarcocci C & Bogazzi F. Diabetes insipidus is an unfavorable prognostic factor for response to glucocorticoids in patients with autoimmune hypophysitis. European Journal of Endocrinology2017177127\u2013135. (https:\/\/doi.org\/10.1530\/EJE-17-0123)"},{"key":"bib11","series-title":"European Journal of Endocrinology","first-page":"101","article-title":"Primary hypophysitis: clinical-pathological correlations","volume":"155","author":"Gutenberg","year":"2006","unstructured":"Gutenberg AHans VPuchner MJKreutzer JBruck WCaturegli P & Buchfelder M. Primary hypophysitis: clinical-pathological correlations. European Journal of Endocrinology2006155101\u2013107. (https:\/\/doi.org\/10.1530\/eje.1.02183)"},{"key":"bib12","series-title":"Neuroendocrinology","first-page":"186","article-title":"Early pulse glucocorticoid therapy and improved hormonal outcomes in primary hypophysitis","volume":"112","author":"Krishnappa","year":"2022","unstructured":"Krishnappa BShah RSarathi VLila ARSehemby MKPatil VASankhe SShah N & Bandgar T. Early pulse glucocorticoid therapy and improved hormonal outcomes in primary hypophysitis. Neuroendocrinology2022112186\u2013195. (https:\/\/doi.org\/10.1159\/000516006)"},{"key":"bib13","series-title":"Journal of Neurology, Neurosurgery, and Psychiatry","first-page":"398","article-title":"Lymphocytic hypophysitis: non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy?","volume":"67","author":"Kristof","year":"1999","unstructured":"Kristof RAVan Roost DKlingmuller DSpringer W & Schramm J. Lymphocytic hypophysitis: non-invasive diagnosis and treatment by high dose methylprednisolone pulse therapy?Journal of Neurology, Neurosurgery, and Psychiatry199967398\u2013402. (https:\/\/doi.org\/10.1136\/jnnp.67.3.398)"},{"key":"bib14","series-title":"Pituitary","first-page":"16","article-title":"Primary (autoimmune) hypophysitis: a single centre experience","volume":"18","author":"Khare","year":"2015","unstructured":"Khare SJagtap VSBudyal SRKasaliwal RKakade HRBukan ASankhe SLila ARBandgar TMenon PS, et al.Primary (autoimmune) hypophysitis: a single centre experience. Pituitary20151816\u201322. (https:\/\/doi.org\/10.1007\/s11102-013-0550-9)"},{"key":"bib15","series-title":"Archives of Endocrinology and Metabolism","first-page":"47","article-title":"Clinical and hormonal characteristics of patients with different types of hypophysitis: a single-center experience","volume":"63","author":"Imga","year":"2019","unstructured":"Imga NNYildirim AEBaser OO & Berker D. Clinical and hormonal characteristics of patients with different types of hypophysitis: a single-center experience. Archives of Endocrinology and Metabolism20196347\u201352. (https:\/\/doi.org\/10.20945\/2359-3997000000102)"},{"key":"bib16","series-title":"Experimental and Clinical Endocrinology and Diabetes","first-page":"14","article-title":"Primary hypophysitis: experience of a Single Tertiary Center","volume":"129","author":"Korkmaz","year":"2021","unstructured":"Korkmaz OPSahin SOzkaya HMApaydin TDurmaz ESHaliloglu ODurcan E & Kadioglu P. Primary hypophysitis: experience of a Single Tertiary Center. Experimental and Clinical Endocrinology and Diabetes202112914\u201321. 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