{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:32Z","timestamp":1784557052151,"version":"3.55.0"},"reference-count":11,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"\n Summary<\/jats:title>\n Dumping syndrome is a rare but potentially serious condition that causes inappropriate postprandial hyperinsulinemia leading to hypoglycemia in children following gastrointestinal surgeries. While dietary modifications are often the first line of treatment, severe cases may require pharmacological intervention to prevent severe hypoglycemia. We present a case of successful treatment of dumping syndrome with diazoxide. A 2-month-old infant with left hypoplastic heart syndrome who underwent single ventricle palliation pathway and developed feeding intolerance that required Nissen fundoplication. Postprandial hypoglycemia was detected following the procedure, with glucose level down to 12 mg\/dL, and the diagnosis of dumping syndrome was established. The patient was successfully managed with diazoxide, which effectively resolved postprandial hypoglycemia without any major adverse events. The patient was eventfully weaned off the medication at the age of 5 months. This case highlights the potential role of diazoxide in the management of pediatric patients with postprandial hyperinsulinemic hypoglycemia secondary to dumping syndrome.<\/jats:p>\n <\/jats:sec>\n \n Learning points<\/jats:title>\n \n \n Dumping syndrome is a possible complication of gastrointestinal surgeries and should be suspected in children with abnormal glucose levels.<\/jats:p>\n <\/jats:list-item>\n \n Postprandial hyperglycemia should be monitored closely for significant subsequent hypoglycemia.<\/jats:p>\n <\/jats:list-item>\n \n Diazoxide might be considered as part of the treatment plan for dumping syndrome.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-23-0137","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T07:17:56Z","timestamp":1709277476000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Successful treatment of dumping syndrome with diazoxide in an infant with hypoplastic left heart syndrome"],"prefix":"10.1530","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0163-8658","authenticated-orcid":true,"given":"Khalifah A","family":"Aldawsari","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Nicklaus Children\u2019s Hospital, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Mattos","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nicklaus Children\u2019s Hospital, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyal M","family":"Khan","sequence":"additional","affiliation":[{"name":"The Heart Institute, Nicklaus Children\u2019s Hospital, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Beckett","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nicklaus Children\u2019s Hospital, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Pagan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nicklaus Children\u2019s Hospital, Miami, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Reviews in Endocrine and Metabolic Disorders","first-page":"577","article-title":"Hyperinsulinemic hypoglycemia in children and adolescents: recent advances in understanding of pathophysiology and management","volume":"21","author":"G\u03cbemes","year":"2020","unstructured":"G\u03cbemes MRahman SAKapoor RRFlanagan SHoughton JALMisra SOliver NDattani MT & Shah P. 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(https:\/\/doi.org\/10.1542\/peds.80.6.937)"},{"key":"bib11","series-title":"Journal of Pediatric Endocrinology and Metabolism","first-page":"1325","article-title":"Dysregulated glucose homeostasis in congenital central hypoventilation syndrome","volume":"31","author":"Musthaffa","year":"2018","unstructured":"Musthaffa YMGoyal VHarris MAKapur NLeger J & Harris M. Dysregulated glucose homeostasis in congenital central hypoventilation syndrome. Journal of Pediatric Endocrinology and Metabolism2018311325\u20131333. 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