{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:27Z","timestamp":1787022807217,"version":"build-2736575974"},"reference-count":6,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>A 56-year-old male presented to hospital with vomiting and was admitted for management of suspected aspiration pneumonia. His medical history was significant for a diagnosis of cerebral palsy and intellectual disability and he had suffered regular generalised tonic\u2013clonic seizures (GTCS) since birth, despite multimodal anticonvulsant treatment. During his admission, his capillary blood glucose was noted to be 1.6 mmol\/L during a seizure. Subsequent investigations confirmed hyperinsulinaemic hypoglycaemia secondary to diffuse pancreatic nesidioblastosis. His seizure disorder completely resolved when management of nesidioblastosis achieved consistent normoglycaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>All patients who suffer seizure should have a blood glucose measured.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Unrecognised hypoglycaemia in a neonate or infant confers a high risk of subsequent neurological damage.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Persistent hyperinsulinaemic hypoglycaemia (PHH) in adults is highly likely to be caused by insulinoma, but diffuse pancreatic hyperinsulinism, particularly after bariatric surgery, should also be considered.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Medical therapy of endogenous hyperinsulinaemic hypoglycaemia is complex, requiring intensive monitoring.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:sec>","DOI":"10.1530\/edm-23-0140","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T10:03:46Z","timestamp":1749463426000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["A hypoglycaemic \u2018Peter Pan\u2019: a paediatric disease in an adult patient?"],"prefix":"10.1530","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2947-3335","authenticated-orcid":true,"given":"Shannon","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kotowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Eur J Pediatr","first-page":"567","article-title":"Insulinoma: only in adults? Case reports and literature review","volume":"173","author":"Gozzi Graf T","year":"2014","unstructured":"Gozzi Graf T\n, \nBr\u00e4ndle M\n, \nClerici T\n, et al\n. Insulinoma: only in adults? Case reports and literature review. Eur J Pediatr 2014 173 567\u2013574. (https:\/\/doi.org\/10.1007\/s00431-013-2005-8)"},{"key":"bib2","series-title":"Seizure","first-page":"10","article-title":"Hypoglycaemic events resembling focal seizures \u2013 a case report and literature review","volume":"94","author":"Dudley A","year":"2022","unstructured":"Dudley A\n, \nKhalil MI\n, \nMullins G\n, et al.\n Hypoglycaemic events resembling focal seizures \u2013 a case report and literature review. Seizure 2022 94 10\u201317. (https:\/\/doi.org\/10.1016\/j.seizure.2021.11.002)"},{"key":"bib3","series-title":"BJPsych Open","first-page":"e198","article-title":"Nesidioblastosis with delayed diagnosis and post-operative complications in a patient with complex psychiatric history","volume":"9","author":"Santore LA","year":"2023","unstructured":"Santore LA\n, \nMandava S\n, \nLee G\n, et al.\n Nesidioblastosis with delayed diagnosis and post-operative complications in a patient with complex psychiatric history. BJPsych Open 2023 9 e198. (https:\/\/doi.org\/10.1192\/bjo.2023.506)"},{"key":"bib4","series-title":"Paediatrics","first-page":"476","article-title":"Neurological outcome of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia","volume":"107","author":"Menni F","year":"2001","unstructured":"Menni F\n, \nde Lonlay P\n, \nSevin C\n, et al.\n Neurological outcome of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia. Paediatrics 2001 107 476\u2013479. (https:\/\/doi.org\/10.1542\/peds.107.3.476)"},{"key":"bib5","series-title":"Semin Fetal Neonatal Med","first-page":"369","article-title":"Congenital hyperinsulinism","volume":"10","author":"Hussain K","year":"2005","unstructured":"Hussain K\n\n. Congenital hyperinsulinism. Semin Fetal Neonatal Med 2005 10 369\u2013376. (https:\/\/doi.org\/10.1016\/j.siny.2005.03.001)"},{"key":"bib6","series-title":"J Formos Med Assoc","first-page":"306","article-title":"Clinical characteristics and long-term outcome of Taiwanese children with congenital hyperinsulinism","volume":"115","author":"Lee CT","year":"2016","unstructured":"Lee CT\n, \nLiu SY\n, \nTung YC\n, et al.\n Clinical characteristics and long-term outcome of Taiwanese children with congenital hyperinsulinism. J Formos Med Assoc 2016 115 306\u2013310. (https:\/\/doi.org\/10.1016\/j.jfma.2015.04.002)"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2025\/2\/EDM-23-0140.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2025\/2\/EDM-23-0140.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2025\/2\/EDM-23-0140.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:48:22Z","timestamp":1784555302000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":6,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/edm-23-0140","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}