{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:17:54Z","timestamp":1784557074539,"version":"3.55.0"},"reference-count":6,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["edm.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["J Cosmet Laser Ther"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"\n Summary<\/jats:title>\n Menstrual cycle abnormalities are common in premenopausal females with Cushing\u2019s syndrome, although the underlying mechanism is poorly understood. Signs and symptoms found in Cushing\u2019s syndrome overlap with polycystic ovarian syndrome (PCOS). The patient is a 33-year-old female previously diagnosed by a gynecologist with PCOS and treated with oral contraceptive pills (OCPs) for 2 years. She then discontinued her OCPs without consulting a clinician, resulting in amenorrhea for 6 months, for which she presented. She also had symptoms of depression and anxiety but had no other signs and symptoms of Cushing\u2019s syndrome, except a plethoric face. Initial lab work showed evidence of central hypogonadism (low luteinizing hormone, follicle-stimulating hormone, and estrogen), so a complete anterior pituitary hormone workup was done. Her thyroid-stimulating hormone was also low with a low free T4 level. Prolactin level was normal, but surprisingly, her AM cortisol level was high. The Cushing\u2019s syndrome workup revealed non-suppressed cortisol after a 1 mg dexamethasone suppression test and positive 24-h urine cortisol with suppressed adrenocorticotrophic hormone. A CT scan of her adrenal glands revealed a left adrenal adenoma. She underwent a left adrenalectomy, after which her menstrual cycles became regular again, and pituitary function has recovered.<\/jats:p>\n <\/jats:sec>\n \n Learning points<\/jats:title>\n \n \n In Cushing's syndrome, female patients can have menstrual abnormalities due to the high cortisol levels, which can affect gonadotrophin levels.<\/jats:p>\n <\/jats:list-item>\n \n We encourage clinicians to include Cushing's syndrome in the differential diagnosis of patients with central hypogonadism.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>","DOI":"10.1530\/edm-23-0152","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T13:55:13Z","timestamp":1721742913000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Amenorrhea as a presentation of Cushing\u2019s syndrome"],"prefix":"10.1530","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8892-8329","authenticated-orcid":true,"given":"Aishah","family":"Alhajeri","sequence":"first","affiliation":[{"name":"Aishah Alhajeri, Internal Medicine Resident, Ministry of Health, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman","family":"Hajji","sequence":"additional","affiliation":[{"name":"Sulaiman Hajji, Endocrinologist, Adan Hospital, Ministry of Health, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-2190","authenticated-orcid":true,"given":"Khalid","family":"Aljenaee","sequence":"additional","affiliation":[{"name":"Khalid Aljenaee, Endocrinologist, Adan Hospital, Ministry of Health, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Clinical Endocrinology","first-page":"436","article-title":"Mortality and morbidity in Cushing\u2019s syndrome in New Zealand","volume":"75","author":"Bolland","year":"2011","unstructured":"Bolland MJHoldaway IMBerkeley JELim SDransfield WJConaglen JVCroxson MSGamble GDHunt PJ & Toomath RJ. Mortality and morbidity in Cushing\u2019s syndrome in New Zealand. Clinical Endocrinology201175436\u2013442. (https:\/\/doi.org\/10.1111\/J.1365-2265.2011.04124.X)"},{"key":"bib2","series-title":"Endocrine","first-page":"555","article-title":"Cushing\u2019s syndrome and pregnancy outcomes: a systematic review of published cases","volume":"55","author":"Caimari","year":"2017","unstructured":"Caimari FValassi EGarbayo PSteffensen CSantos ACorcoy R & Webb SM. Cushing\u2019s syndrome and pregnancy outcomes: a systematic review of published cases. Endocrine201755555\u2013563. (https:\/\/doi.org\/10.1007\/S12020-016-1117-0)"},{"key":"bib3","series-title":"Journal of Endocrinological Investigation","first-page":"101","article-title":"Erythropoiesis in Cushing syndrome: sex-related and subtype-specific differences. Results from a monocentric study","volume":"47","author":"Detomas","year":"2024","unstructured":"Detomas MDeutschbein TTamburello MChifu IKimpel OSbiera SKroiss MFassnacht M & Altieri B. Erythropoiesis in Cushing syndrome: sex-related and subtype-specific differences. Results from a monocentric study. Journal of Endocrinological Investigation202447101\u2013113. (https:\/\/doi.org\/10.1007\/s40618-023-02128-x)"},{"key":"bib4","article-title":"Toronto Notes 2023\u202f: Comprehensive Medical Reference and a Review for the Medical Council of Canada Qualifying Exam (MCCQE","author":"Erickson","year":"n.d.","unstructured":"Erickson AWParker JKhat DZLi MGaebe KLi AMehra VTan CCChan JLu J and Ramendra R. Toronto Notes 2023\u202f: Comprehensive Medical Reference and a Review for the Medical Council of Canada Qualifying Exam (MCCQE). n.d."},{"key":"bib5","series-title":"Clinical Endocrinology","first-page":"493","article-title":"How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing\u2019s syndrome?","volume":"53","author":"Kaltsas","year":"2000","unstructured":"Kaltsas GAKorbonits M, Isidori AMWebb JAWTrainer PJMonson JPBesser GM & Grossman AB. How common are polycystic ovaries and the polycystic ovarian syndrome in women with Cushing\u2019s syndrome?Clinical Endocrinology200053493\u2013500. (https:\/\/doi.org\/10.1046\/j.1365-2265.2000.01117.x)"},{"key":"bib6","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"3083","article-title":"Menstrual abnormalities in women with Cushing\u2019s disease are correlated with hypercortisolemia rather than raised circulating androgen levels","volume":"83","author":"Lado-Abeal","year":"1998","unstructured":"Lado-Abeal JRodriguez-Arnao JNewell-Price JDCPerry LAGrossman ABBesser GM & Trainer PJ. Menstrual abnormalities in women with Cushing\u2019s disease are correlated with hypercortisolemia rather than raised circulating androgen levels. Journal of Clinical Endocrinology and Metabolism1998833083\u20133088. (https:\/\/doi.org\/10.1210\/JCEM.83.9.5084)"}],"container-title":["Endocrinology, Diabetes & Metabolism Case Reports"],"original-title":[],"link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2024\/3\/EDM23-0152.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2024\/3\/EDM23-0152.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2024\/3\/EDM23-0152.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:48:23Z","timestamp":1784555303000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/edm\/article\/3785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":6,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/edm-23-0152","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]}}}