{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:17:52Z","timestamp":1783448272345,"version":"3.55.0"},"reference-count":22,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":518,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Paediatric pituitary adenomas are rare in children and adolescents and differ from adults in both clinical presentation and management. We present the case of a 14-year-old female with primary amenorrhoea secondary to a macroprolactinoma, showing a modest radiological and biochemical response to dopamine agonist (DA) therapy. Despite a 10-month duration of increasing DA therapy, initial symptoms of primary amenorrhoea and hyperprolactinaemia persisted, with new symptoms of weight gain, lethargy and low mood. A transsphenoidal resection of the macroprolactinoma was successfully performed, followed by the initiation of additional hormonal therapy. This case explores the unique challenges of treating a macroprolactinoma refractory to medical management in adolescence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-24-0033","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T06:53:35Z","timestamp":1734936815000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["Macroprolactinoma in an adolescent female with primary amenorrhoea"],"prefix":"10.1530","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-4395","authenticated-orcid":true,"given":"Ning","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital 1 , , ,","place":["Sydney, New South Wales, Australia"]},{"name":"Northern Clinical Medical School, University of Sydney 2 , , ,","place":["Sydney, New South Wales, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"White","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital 1 , , ,","place":["Sydney, New South Wales, Australia"]},{"name":"Northern Clinical Medical School, University of Sydney 2 , , ,","place":["Sydney, New South Wales, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Weir","sequence":"additional","affiliation":[{"name":"Northern Clinical Medical School, University of Sydney 2 , , ,","place":["Sydney, New South Wales, Australia"]},{"name":"Department of Endocrinology, Nepean Hospital 3 , , ,","place":["Sydney, New South Wales, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Dexter","sequence":"additional","affiliation":[{"name":"Northern Clinical Medical School, University of Sydney 2 , , ,","place":["Sydney, New South Wales, Australia"]},{"name":"Department of Neurosurgery, Westmead Hospital 4 , , ,","place":["Sydney, New South Wales, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winny","family":"Varikatt","sequence":"additional","affiliation":[{"name":"Northern Clinical Medical School, University of Sydney 2 , , ,","place":["Sydney, New South Wales, Australia"]},{"name":"Department of Tissue Pathology and Diagnostic Oncology, Westmead Hospital 5 , , ,","place":["Sydney, New South Wales, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-1348","authenticated-orcid":true,"given":"Sarah J","family":"Glastras","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital 1 , , ,","place":["Sydney, New South Wales, Australia"]},{"name":"Northern Clinical Medical School, University of Sydney 2 , , ,","place":["Sydney, New South Wales, 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