{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:16Z","timestamp":1783448296469,"version":"3.55.0"},"reference-count":10,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":255,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Functional constipation is a common condition in infants. Phosphate-containing enemas (PCEs) are contraindicated in neonates due to the significant risk of severe electrolyte disturbances. We report a case of a 28-day-old neonate presenting with constipation and vomiting following the administration of PCEs. This resulted in hyperphosphatemia, hypocalcemia, and a prolonged QTc interval \u2013 critical conditions requiring urgent intervention. Management included hyperhydration, intravenous calcium gluconate, and oral alfacalcidol, which led to complete clinical recovery within 60 h. This case underscores the serious risks associated with inappropriate use of over-the-counter PCEs in neonates, even in the absence of underlying health conditions. It also highlights the importance of early recognition and effective supportive therapy to mitigate potential life-threatening complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-25-0032","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:30:17Z","timestamp":1761741017000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":1,"title":["Iatrogenic neonatal hyperphosphatemia due to phosphate-containing enema"],"prefix":"10.1530","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-9126","authenticated-orcid":true,"given":"Elise","family":"Nauwynck","sequence":"first","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Vanbesien","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Staels","sequence":"additional","affiliation":[{"name":"1"},{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Gies","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"De Cuyper","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Huysentruyt","sequence":"additional","affiliation":[{"name":"5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Mauel","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"De Schepper","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2026070713541839100_bib5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.curtheres.2006.10.004","article-title":"Effects of a 250-mL enema containing sodium phosphate on electrolyte concentrations in healthy volunteers: an open-label, randomized, controlled, two-period, crossover clinical trial","volume":"67","author":"Sedaba","year":"2006","journal-title":"Curr Ther Res Clin Exp"},{"key":"2026070713541839100_bib4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00383-012-3124-4","article-title":"Severe hyperphosphatemia after administration of sodium-phosphate containing laxatives in children: case series and systematic review of literature","volume":"28","author":"Ladenhauf","year":"2012","journal-title":"Pediatr Surg Int"},{"key":"2026070713541839100_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MPG.0000000000000266","article-title":"Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN","volume":"58","author":"Tabbers","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2026070713541839100_bib6","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1001\/jama.1987.03390160076030","article-title":"Fatal poisoning from sodium phosphate enema. 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