{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:00Z","timestamp":1783448280979,"version":"3.55.0"},"reference-count":12,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":255,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Thyroid stimulating hormone (TSH)-secreting PitNETs, also called TSHomas, are rare benign pituitary tumors with an incidence of 1.0 per million population. They are generally diagnosed in the context of central hyperthyroidism and\/or mass-effect central symptomatology (e.g. headache, bitemporal hemianopsia, and panhypopituitarism). Although TSHomas are more often macroadenomas than microadenomas at the time of diagnosis, diagnosing TSHomas may be challenging because laboratory findings and clinical presentation are not always obvious. The treatment of choice is the surgical resection of the adenoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-25-0082","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:59:28Z","timestamp":1762531168000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["A subtle initial clinical presentation of a TSH-secreting PitNET"],"prefix":"10.1530","volume":"2025","author":[{"given":"Rosanna","family":"Bu\u00e8","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4226-4131","authenticated-orcid":true,"given":"Lauro","family":"Gianola","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-4937","authenticated-orcid":true,"given":"Pierpaolo","family":"Trimboli","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"2026070713532833500_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000351007","article-title":"2013 European Thyroid Association Guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumors","volume":"2","author":"Beck-Peccoz","year":"2013","journal-title":"Eur Thyroid J"},{"key":"2026070713532833500_bib2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1530\/eje.0.1480433","article-title":"The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients","volume":"148","author":"Valdes Socin","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"2026070713532833500_bib3","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0140-6736(85)92429-8","article-title":"A new strategy for thyroid function testing","volume":"1","author":"Caldwell","year":"1985","journal-title":"Lancet"},{"key":"2026070713532833500_bib4","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1210\/jcem-69-3-684","article-title":"Measurement of thyrotropin in clinical and subclinical hyperthyroidism using a new chemiluminescent assay","volume":"69","author":"Ross","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713532833500_bib5","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3171\/2014.7.JNS1471","article-title":"Clinicopathological characteristics and therapeutic outcomes in thyrotropin-secreting pituitary adenomas: a single-center study of 90 cases","volume":"121","author":"Yamada","year":"2014","journal-title":"J Neurosurg"},{"key":"2026070713532833500_bib6","article-title":"2024 European Thyroid Association Guidelines on diagnosis and management of genetic disorders of thyroid hormone transport, metabolism and action","volume":"13","author":"Persani","year":"2024","journal-title":"Eur Tyhroid J"},{"key":"2026070713532833500_bib7","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1530\/EJE-16-1029","article-title":"Diagnostic approach to TSH-producing pituitary adenoma","volume":"177","author":"Tj\u00f6rnstrand","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"2026070713532833500_bib8","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3390\/jpm13101471","article-title":"Macro-TSH: an uncommon explanation for persistent TSH elevation that thyroidologists have to keep in mind","volume":"13","author":"Chiardi","year":"2023","journal-title":"J Pers Med"},{"key":"2026070713532833500_bib9","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s40618-019-01066-x","article-title":"A 2019 update on TSH-secreting pituitary adenomas","volume":"42","author":"Beck-Peccoz","year":"2019","journal-title":"J Endocrinol Investig"},{"key":"2026070713532833500_bib10","first-page":"583","article-title":"Clinical outcome and evidence of high rate post-surgical anterior hypopituitarism in a cohort of TSH-secreting adenoma patients: might somatostatin analogs have a role as first-line therapy?","volume":"18","author":"Gatto","year":"2015","journal-title":"Thyroid"},{"key":"2026070713532833500_bib11","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1210\/jc.2013-4376","article-title":"Thyrotropin secreting pituitary adenoma: outcome of pituitary surgery and irradiation","volume":"99","author":"Malchiodi","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713532833500_bib12","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1530\/eje.0.1480433","article-title":"The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients","volume":"148","author":"Valdes Socin","year":"2003","journal-title":"Eur J Endocrinol"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2025\/4\/EDM-25-0082.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2025\/4\/EDM-25-0082.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/edm\/article-pdf\/doi\/10.1530\/EDM-25-0082\/502437\/edm-25-0082.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/edm\/article-pdf\/doi\/10.1530\/EDM-25-0082\/502437\/edm-25-0082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:54:02Z","timestamp":1783446842000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/edm\/article\/2025\/4\/e250082\/75386\/A-subtle-initial-clinical-presentation-of-a-TSH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1530\/edm-25-0082","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"e250082"}}