{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:16Z","timestamp":1783448296483,"version":"3.55.0"},"reference-count":6,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":165,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Apparent mineralocorticoid excess (AME) syndrome is a rare condition caused by the inhibition of the renal enzyme 11\u03b2-hydroxysteroid dehydrogenase type 2 (11\u03b2-HSD2). The most common acquired cause is chronic liquorice ingestion. We report the case of a 61-year-old woman who developed profound hypokalaemia, metabolic alkalosis, and QT prolongation due to excessive liquorice tea consumption. This case underscores the importance of detailed dietary history in patients with unexplained electrolyte disturbances and demonstrates the potentially fatal cardiovascular consequences of a widely available herbal remedy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-25-0120","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T16:31:26Z","timestamp":1767630686000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of apparent mineralocorticoid excess induced by chronic liquorice ingestion"],"prefix":"10.1530","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7401-5913","authenticated-orcid":true,"given":"Aparajita","family":"Roy","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran","family":"Mullins","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"2026070713532290600_bib1","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.3390\/plants10122751","article-title":"Glycyrrhiza glabra (Licorice): a comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology","volume":"10","author":"Wahab","year":"2021","journal-title":"Plants"},{"key":"2026070713532290600_bib2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/s12967-022-03698-9","article-title":"Apparent mineralocorticoid excess: comprehensive overview of molecular genetics","volume":"20","author":"Lu","year":"2022","journal-title":"J Transl Med"},{"key":"2026070713532290600_bib3","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.3390\/nu15183866","article-title":"Liquorice toxicity: a comprehensive narrative review","volume":"15","author":"Ceccuzzi","year":"2023","journal-title":"Nutrients"},{"key":"2026070713532290600_bib4","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1191\/096032700682694251","article-title":"Glycyrrhizic acid: the assessment of a no effect level","volume":"19","author":"van Gelderen","year":"2000","journal-title":"Hum Exp Toxicol"},{"key":"2026070713532290600_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.719197","article-title":"Clinical risk factors of licorice-induced pseudoaldosteronism based on glycyrrhizin-metabolite concentrations: a narrative review","volume":"8","author":"Yoshino","year":"2021","journal-title":"Front Nutr"},{"key":"2026070713532290600_bib6","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ajcnut.2024.01.011","article-title":"A low dose of daily licorice intake affects renin, aldosterone, and home blood pressure in a randomized crossover trial","volume":"119","author":"af Geijerstam","year":"2024","journal-title":"Am J Clin Nutr"}],"container-title":["Endocrinology, Diabetes &amp; Metabolism Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2026\/1\/EDM-25-0120.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/edm.bioscientifica.com\/downloadpdf\/journals\/edm\/2026\/1\/EDM-25-0120.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/edm\/article-pdf\/doi\/10.1530\/EDM-25-0120\/504680\/edm-25-0120.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/edm\/article-pdf\/doi\/10.1530\/EDM-25-0120\/504680\/edm-25-0120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:54:00Z","timestamp":1783446840000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/edm\/article\/2026\/1\/EDM250120\/75384\/A-rare-case-of-apparent-mineralocorticoid-excess"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1530\/edm-25-0120","relation":{},"ISSN":["2052-0573"],"issn-type":[{"value":"2052-0573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"article-number":"EDM250120"}}