{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:25Z","timestamp":1783448305659,"version":"3.55.0"},"reference-count":29,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":165,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Papillary thyroid carcinoma (PTC) is the most frequent type of differentiated thyroid cancer, while thyroglossal duct cysts (TGDCs) are common congenital anomalies of the neck. The coexistence of PTC within a TGDC is exceptionally rare, with a reported incidence of less than 1.5%. We present three Peruvian cases of PTC arising in TGDCs. The patients (two females and one male; age range: 34\u201347 years) presented with progressive midline cervical masses of two to four years\u2019 duration. All underwent cervical ultrasound, contrast-enhanced computed tomography, and fine-needle aspiration biopsy. Histopathology confirmed PTC, including classical and follicular variants. Surgical management varied: two patients underwent Sistrunk procedure alone, while one required Sistrunk surgery followed by total thyroidectomy, cervical lymph node dissection, and radioactive iodine (RAI) therapy. All patients remain disease-free after 6\u201312 years of follow-up. The diagnosis of carcinoma in TGDC is often incidental, but preoperative imaging and cytology can raise suspicion. Optimal management remains controversial; while the Sistrunk procedure may be sufficient in most cases of PTC confined to TGDC without extracapsular extension, in some scenarios, such as the presence of suspicious thyroid nodules, extracystic extension, and cervical lymph node metastasis, an additional thyroidectomy and RAI therapy may be warranted. In conclusion, PTC in TGDC is a rare entity with generally favorable prognosis. Early recognition, individualized treatment, and multidisciplinary decision-making are essential for optimal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-25-0139","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:03:44Z","timestamp":1767884624000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":2,"title":["Papillary thyroid carcinoma in thyroglossal duct cyst: a Peruvian case series"],"prefix":"10.1530","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-3727","authenticated-orcid":true,"given":"Jos\u00e9 Luis","family":"Paz-Ibarra","sequence":"first","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-0585","authenticated-orcid":true,"given":"Marialejandra","family":"Delgado Rojas","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0131-234X","authenticated-orcid":true,"given":"Edward","family":"Paucar Holgado","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-3999","authenticated-orcid":true,"given":"Jenyfer Mar\u00eda","family":"Fuentes-Mendoza","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-3101","authenticated-orcid":true,"given":"Luis","family":"Concepci\u00f3n-Urteaga","sequence":"additional","affiliation":[{"name":"5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-095X","authenticated-orcid":true,"given":"Juan Eduardo","family":"Quiroz-Aldave","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-1875","authenticated-orcid":true,"given":"Marcio Jos\u00e9","family":"Concepci\u00f3n-Zavaleta","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5198-4113","authenticated-orcid":true,"given":"Jos\u00e9","family":"Somocurcio Peralta","sequence":"additional","affiliation":[{"name":"1"},{"name":"7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2026070713550246200_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26115173","article-title":"Thyroid cancer: epidemiology, classification, risk factors, diagnostic and prognostic markers, and current treatment strategies","volume":"26","author":"Forma","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026070713550246200_bib2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S2213-8587(22)00035-3","article-title":"The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020","volume":"10","author":"Pizzato","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026070713550246200_bib3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.2023.26348","article-title":"Thyroid cancer: a review","volume":"331","author":"Boucai","year":"2024","journal-title":"JAMA"},{"key":"2026070713550246200_bib4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4132\/jptm.2024.10.11","article-title":"Cytologic hallmarks and differential diagnosis of papillary thyroid carcinoma subtypes","volume":"58","author":"Harahap","year":"2024","journal-title":"J Pathol Transl Med"},{"key":"2026070713550246200_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3390\/genes15050621","article-title":"Papillary thyroid cancer remodels the genetic information processing pathways","volume":"15","author":"Iacobas","year":"2024","journal-title":"Genes"},{"key":"2026070713550246200_bib6","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.endonu.2015.02.006","article-title":"en representaci\u00f3n del Grupo de Trabajo de C\u00e1ncer de Tiroides de la Sociedad Espa\u00f1ola de Endocrinolog\u00eda y Nutrici\u00f3n. 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