{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:18:05Z","timestamp":1783448285021,"version":"3.55.0"},"reference-count":6,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":165,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Ectopic adrenocorticotropic hormone (ACTH) secretion is a rare cause of Cushing\u2019s syndrome (CS), often associated with neuroendocrine tumours (NETs). Early diagnosis can be difficult due to variable clinical manifestations and psychiatric symptoms that may obscure the underlying endocrine disorder. We report a case of severe ectopic ACTH-dependent Cushing\u2019s syndrome secondary to a pulmonary NET, highlighting the importance of multidisciplinary management, advanced imaging with positron emission tomography\/computed tomography with gallium-68-labelled DOTA-D-Phe-Tyr-octreotide (68Ga-DOTATOC PET-CT) and aggressive biochemical control to enable curative surgery and full clinical recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-25-0166","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:20:19Z","timestamp":1774549219000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary neuroendocrine tumour-associated ectopic Cushing\u2019s syndrome: diagnostic challenges and multidisciplinary management"],"prefix":"10.1530","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4761-5981","authenticated-orcid":true,"given":"Rub\u00e9n D","family":"Carrasco B","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Juanes","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Marr\u00f3n","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00f1a","family":"Veras","sequence":"additional","affiliation":[{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Soledad","family":"Librizzi","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Calatayud","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"2026070713553021800_bib1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tem.2023.12.003","article-title":"A clinical perspective on ectopic Cushing\u2019s syndrome","volume":"35","author":"Ragnarsson","year":"2024","journal-title":"Trends Endocrinol Metab"},{"key":"2026070713553021800_bib2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1159\/000540707","article-title":"Ectopic ACTH-dependent Cushing\u2019s syndrome emerging at a late stage in a neuroendocrine neoplasm: a case report","volume":"17","author":"Meyers","year":"2024","journal-title":"Case Rep Oncol"},{"key":"2026070713553021800_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.833644","article-title":"Ketoconazole- and metyrapone-induced reductions on urinary steroid metabolites alter the urinary free cortisol immunoassay reliability in cushing syndrome","volume":"13","author":"Vega-Beyhart","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070713553021800_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1530\/EJE-14-0913","article-title":"Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole","volume":"172","author":"Corcuff","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"2026070713553021800_bib5","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1210\/jc.2011-0536","article-title":"Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing\u2019s syndrome","volume":"96","author":"Kamenick\u00fd","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070713553021800_bib6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.5603\/ep.100560","article-title":"Is [68Ga]Ga-DOTA-TATE PET\/CT useful in the diagnosis of patients suspected of ECS?","volume":"75","author":"Iskandar","year":"2024","journal-title":"Endokrynol Pol"}],"container-title":["Endocrinology, Diabetes &amp; 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