{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:56:09Z","timestamp":1790938569911,"version":"4.1.0"},"reference-count":7,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>An 80-year-old female patient presented with a 10-year history of progressively worsening diarrhea and chronic hyponatremia. An abdominal computed tomography (CT) revealed a 6.8-centimeter right adrenal mass. A Ga-68 DOTATATE positron emission tomography (PET)\/CT scan subsequently demonstrated a significant expression of somatostatin receptors on the tumoral shell (maximal SUV of 14.4), associated with a hypometabolic central portion. Endocrine investigation indicated elevated levels of both urinary and plasmatic normetanephrines. Given the watery diarrhea, VIP levels were measured, which were markedly elevated. Surgical resection confirmed a composite pheochromocytoma\u2013ganglioneuroma with VIP immunoreactivity in both tumor components. In the postoperative period, the plasma levels of VIP and normetanephrines returned to normal with resolution of diarrhea, hyponatremia, and hypertension. This case illustrates a rare instance of composite pheochromocytoma\u2013ganglioneuroma with co-secretion of catecholamines and VIP, with evidence of VIP production in both tumor components. The finding of VIP secretion in the pheochromocytoma and the ganglioneuroma suggests that both tumors might originate from the same cell of neural crest origin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-25-0184","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:14:01Z","timestamp":1790936041000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["Composite pheochromocytoma\u2013ganglioneuroma secreting vasoactive intestinal peptide"],"prefix":"10.1530","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9077-1552","authenticated-orcid":true,"given":"Benjamin","family":"Brochu","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke 1 , ,","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9791-2118","authenticated-orcid":true,"given":"Matthieu","family":"St-Jean","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke 1 , ,","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Collin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre Hospitalier Universitaire de Sherbrooke 2 , ,","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"Temmar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Hospitalier Universitaire de Sherbrooke 3 , ,","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Bernier","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke 1 , ,","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Dandurand","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke 1 , ,","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Massicotte","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke 1 , ,","place":["Sherbrooke, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026100206135876900_bib1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1007\/s00268-012-1488-1","article-title":"Ectopic hormone-secreting pheochromocytoma: a francophone observational study","volume":"36","author":"Kirkby-Bott","year":"2012","journal-title":"World J Surg"},{"key":"2026100206135876900_bib2","first-page":"158","article-title":"Vasoactive intestinal peptide-secreting pheochromocytoma: a case report and review of literature","volume":"8","author":"Yee","year":"2022","journal-title":"AACE Clin Case Rep"},{"key":"2026100206135876900_bib3","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.18039.1","article-title":"Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal 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