{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:31:06Z","timestamp":1787059866838,"version":"build-2736575974"},"reference-count":11,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":93,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>We report a case of a 48-year-old man newly diagnosed with type 2 diabetes mellitus (T2DM), presenting with a critically elevated HbA1c of 10.3%, who achieved near-normal glycaemic control (HbA1c 6.0%) through a structured, three-month lifestyle intervention without initiation of any antidiabetic pharmacotherapy. The intervention entailed aerobic and resistance exercise, nutritional counselling, weekly coaching, and continuous activity monitoring. Notably, body weight remained constant (\u223c98.4 kg; BMI:31.8 kg\/m2), while significant improvements occurred in body composition: \u22123.2 kg fat mass, \u22121.2 L visceral fat, +1.5 kg skeletal muscle, and \u22125 cm waist circumference. This case underscores the potential for non-pharmacological remission in patients with high baseline glycaemic dysregulation and supports early implementation of structured lifestyle programmes in clinical practice despite significantly elevated HbA1c.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Learning points<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1530\/edm-25-0188","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:47:47Z","timestamp":1775134067000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-2","source":"Crossref","is-referenced-by-count":0,"title":["The power of lifestyle intervention to induce glycaemic control in a patient with newly diagnosed type 2 diabetes and HbA1c &amp;gt;10%"],"prefix":"10.1530","volume":"2026","author":[{"given":"Antonio","family":"Ferreira","sequence":"first","affiliation":[{"name":"Medical Faculty, University of Basel, Basel, Switzerland 1"},{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, Kantonsspital Olten, Olten, Switzerland 2"},{"name":"Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Z\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, Kantonsspital Olten, Olten, Switzerland 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Y","family":"Donath","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology and Integrated Centre of Excellence in Metabolic Health, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM) and Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Canada 4"},{"name":"Clinical Trial Unit, Baden Cantonal Hospital, Baden, Switzerland 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-6235","authenticated-orcid":true,"given":"Matthias","family":"Hepprich","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Basel, Basel, Switzerland 1"},{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, Kantonsspital Olten, Olten, Switzerland 2"},{"name":"Endocrinology and Nutrition Centre, St. Clara Hospital, Basel, Switzerland 6"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"2026081809174279100_bib1","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s00125-022-05787-2","article-title":"Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"65","author":"Davies","year":"2022","journal-title":"Diabetologia"},{"key":"2026081809174279100_bib2","doi-asserted-by":"crossref","first-page":"40060","DOI":"10.57187\/smw.2023.40060","article-title":"Swiss recommendations of the Society for Endocrinology and Diabetes (SGED\/SSED) for the treatment of type 2 diabetes mellitus (2023)","volume":"153","author":"Gastaldi","year":"2023","journal-title":"Swiss Med Wkly"},{"key":"2026081809174279100_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2025.112027","article-title":"Effects of exercise training and physical activity advice on HbA1c in people with type 2 diabetes: a network meta-analysis of randomized controlled trials","volume":"221","author":"Garcia","year":"2025","journal-title":"Diabetes Res Clin Pract"},{"key":"2026081809174279100_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2337\/dc06-1128","article-title":"Physical activity in U.S. adults with diabetes and at risk for developing diabetes, 2003","volume":"30","author":"Morrato","year":"2007","journal-title":"Diabetes Care"},{"key":"2026081809174279100_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2337\/diacare.29.03.06.dc05-2165","article-title":"Are health care professionals advising patients with diabetes or at risk for developing diabetes to exercise more?","volume":"29","author":"Morrato","year":"2006","journal-title":"Diabetes Care"},{"key":"2026081809174279100_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00400697","article-title":"A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population","volume":"36","author":"Young","year":"1993","journal-title":"Diabetologia"},{"key":"2026081809174279100_bib7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.metabol.2014.10.018","article-title":"Effect of lifestyle intervention in patients with type 2 diabetes: a meta-analysis","volume":"64","author":"Chen","year":"2015","journal-title":"Metabolism"},{"key":"2026081809174279100_bib8","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.jand.2015.02.031","article-title":"Lifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review andmeta-analysis of randomized clinical trials","volume":"115","author":"Franz","year":"2015","journal-title":"J Acad Nutr Diet"},{"key":"2026081809174279100_bib9","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.numecd.2017.06.009","article-title":"Intensive lifestyle intervention is particularly advantageous in poorly controlled type 2 diabetes","volume":"27","author":"Sbroma Tomaro","year":"2017","journal-title":"Nutr Metabol Cardiovasc Dis"},{"key":"2026081809174279100_bib10","first-page":"1179","article-title":"Effectiveness of interventions using empowerment concept for patients with chronic disease: a systematic review","volume":"7","author":"Chen","year":"2009","journal-title":"JBI Libr Syst Rev"},{"key":"2026081809174279100_bib11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/dom.13171","article-title":"Effect of non-surgical weight management on weight and glycaemic control in people with type 2 diabetes: a comparison of interventional and non-interventional outcomes at 3 years","volume":"20","author":"Botha","year":"2018","journal-title":"Diabetes Obes Metab"}],"container-title":["Endocrinology, Diabetes &amp; 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