{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:29:55Z","timestamp":1789694995920,"version":"4.0.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: We studied posterior pituitary function in 27 patients with Sheehan\u2019s syndrome and 14 controls.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: All patients were investigated by water deprivation test and 26 of them by 5% hypertonic saline infusion test. None of the patients had symptoms of diabetes insipidus and all patients were on adequate glucocorticoid and thyroid hormone replacement therapy before testing.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: According to dehydration test, 8 (29.6%) patients had partial diabetes insipidus (PDI group) and 19 (70.3%) had normal response (non-DI group). During the 5% hypertonic saline infusion test, the maximal plasma osmolality was higher in PDI (305 \u00b1 4.3) and non-DI (308 \u00b1 1.7) groups when compared with controls (298 \u00b1 1.7 mOsm\/kg; <jats:italic>P<\/jats:italic> &lt; 0.005), but the maximal urine osmolality was lower in PDI group (565 \u00b1 37) than in non-DI (708 \u00b1 45) and control (683 \u00b1 17 mOsm\/kg) groups (<jats:italic>P<\/jats:italic> &lt; 0.05). The osmotic threshold for thirst perception was higher in PDI (296 \u00b1 4.3) and non-DI (298 \u00b1 1.4) groups when compared with control group (287 \u00b1 1.5 mOsm\/kg) (<jats:italic>P<\/jats:italic> &lt; 0.005). Basal plasma osmolalities were also higher in PDI (294 \u00b1 1.0) and non-DI (297 \u00b1 1.1) groups than in controls (288 \u00b1 1.2 mOsm\/kg; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: Our findings demonstrated that patients with Sheehan\u2019s syndrome have an impairment of neurohypophyseal function. The thirst center may be affected by ischemic damage and the osmotic threshold for the onset of thirst in patients with Sheehan\u2019s syndrome is increased.<\/jats:p>","DOI":"10.1530\/eje-06-0727","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T14:18:20Z","timestamp":1177683500000},"page":"563-567","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":42,"title":["Posterior pituitary function in Sheehan\u2019s syndrome"],"prefix":"10.1093","volume":"156","author":[{"given":"Hulusi","family":"Atmaca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Tanriverdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cumali","family":"Gokce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursad","family":"Unluhizarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahrettin","family":"Kelestimur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/156\/5\/1560563.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/156\/5\/1560563.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:19:54Z","timestamp":1676391594000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/156\/5\/563\/6695841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1530\/eje-06-0727","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}