{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:20:13Z","timestamp":1789442413811,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: Many polycystic ovary syndrome (PCOS) women suffer from adiposity and insulin resistance (IR), which play an important role in the development and maintenance of PCOS. Adipocyte fatty acid-binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity and IR. Thus, as observed with other adipose tissue derived factors, secreted A-FABP might be involved in the pathogenesis of obesity-associated disorders such as PCOS.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: Plasma A-FABP concentrations were measured in 102 non-diabetic PCOS women, and associations with markers of obesity, IR, inflammation, and hyperandrogenism were investigated by correlation and multiple linear regression analyses. The effect of lifestyle intervention on A-FABP was studied in a second cohort of 17 obese PCOS women.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: A-FABP correlated with body mass index (BMI; <jats:italic>R<\/jats:italic> = 0.694, <jats:italic>P<\/jats:italic> &lt; 0.001), dual-energy X-ray-absorptiometry (DEXA) fat mass (<jats:italic>R<\/jats:italic> = 0.729, <jats:italic>P<\/jats:italic> &lt; 0.001), DEXA lean body mass (<jats:italic>R<\/jats:italic> = 0.399, <jats:italic>P<\/jats:italic> = 0.001), HOMA %S (<jats:italic>R<\/jats:italic> = \u22120.435, <jats:italic>P<\/jats:italic> &lt; 0.001), hsCRP (<jats:italic>R<\/jats:italic> = 0.355, <jats:italic>P<\/jats:italic> = 0.001), and free testosterone (fT; <jats:italic>R<\/jats:italic> = 0.230, <jats:italic>P<\/jats:italic> = 0.02). Adjusted for age, smoking, and glucose metabolism the association of A-FABP with HOMA %S was still significant (<jats:italic>P<\/jats:italic> &lt; 0.001), whereas the associations with fT (<jats:italic>P<\/jats:italic> = 0.09) and hsCRP (<jats:italic>P<\/jats:italic> = 0.25) were not. Inclusion of BMI into the model abolished the impact of A-FABP on HOMA %S. In BMI-matched PCOS women (<jats:italic>n<\/jats:italic> = 20 pairs), neither HOMA %S (<jats:italic>P<\/jats:italic> = 0.3) nor fT (<jats:italic>P<\/jats:italic> = 0.6) were different despite different A-FABP levels (<jats:italic>P<\/jats:italic> &lt; 0.001), and in 17 obese PCOS women undergoing a lifestyle intervention, changes in IR were not paralleled by changes in A-FABP.<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: Circulating A-FABP was correlated with markers of obesity, but had no major impact on IR, inflammation, or hyperandrogenemia in PCOS women.<\/jats:p>","DOI":"10.1530\/eje-07-0102","type":"journal-article","created":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T17:18:20Z","timestamp":1185470300000},"page":"195-200","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":50,"title":["Adipocyte fatty acid-binding protein is associated with markers of obesity, but is an unlikely link between obesity, insulin resistance, and hyperandrogenism in polycystic ovary syndrome women"],"prefix":"10.1093","volume":"157","author":[{"given":"Matthias","family":"Mo\u0308hlig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin O","family":"Weickert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ghadamgadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Machlitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Pfu\u0308ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman M","family":"Arafat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas F H","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Scho\u0308fl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"7","key":"1_10396053","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1210\/jc.85.7.2434","volume":"85","author":"Asuncion","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; 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