{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:18:04Z","timestamp":1777349884685,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: The diagnosis of primary hyperparathyroidism (PHP) can be difficult in patients with normal plasma calcium or parathyroid hormone (PTH) levels. We perfected a standardized short-time i.v. calcium loading test in healthy controls (HC) and compared the results with those of patients with PHP.<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: Sixteen HC received 0.33 mmol\/kg calcium gluconate intravenously for 3 h. Plasma calcium and serum PTH levels (assayed with immunoluminescent sandwich methods) were measured before, at the end of the infusion and 3 h later. Results were compared with those of 16 PHP patients.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: In HC, basal total plasma calcium (mean \u00b1 <jats:sc>s.e.m<\/jats:sc>.) was 2.33 \u00b1 0.02 mmol\/l. At the end of calcium loading, calcemia reached 3.21 \u00b1 0.05 mmol\/l and decreased to 2.94 \u00b1 0.08 mmol\/l 3 h later. In PHP patients, basal plasma calcium was 2.54 \u00b1 0.03 mmol\/l and reached similar values as in HC during the testing. Basal serum PTH levels were 32.5 \u00b1 3.3 ng\/l in HC and 86.9 \u00b1 6.3 ng\/l in PHP. At the end of calcium loading, they dropped to 8.8 \u00b1 0.6 ng\/l (HC) and to 31.4 \u00b1 4.2 ng\/l (PHP). Three hours later, they were 11.6 \u00b1 0.8 and 39.8 \u00b1 4.0 ng\/l respectively. There was a cut-off in serum PTH values between the two groups at the end of calcium loading and 3 h later.<\/jats:p>\n      <jats:p><jats:italic>Conclusion<\/jats:italic>: The standardized short-time PTH suppression test appears reliable to differentiate healthy subjects from PHP whose serum PTH levels remain &gt;14 and &gt;23 ng\/ml respectively at the end of loading and 3 h later. This well-tolerated and easily performed test could be used for the diagnosis of PHP in patients suspected for the disease despite the normality of some basal biological markers.<\/jats:p>","DOI":"10.1530\/eje-07-0132","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T21:34:22Z","timestamp":1188596062000},"page":"351-357","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of a standardized short-time calcium suppression test in healthy subjects: interest for the diagnosis of primary hyperparathyroidism"],"prefix":"10.1093","volume":"157","author":[{"given":"Isabelle","family":"Titon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Cailleux-Bounacer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Pierre","family":"Basuyau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herve\u0301","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"Savoure\u0301","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marc","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/3\/1570351.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/3\/1570351.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:20:11Z","timestamp":1676391611000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/157\/3\/351\/6695975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-07-0132","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}