{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:51:19Z","timestamp":1784141479233,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>: Polycystic ovary syndrome (PCOS) is a common disorder associated with a wide range of endocrine and metabolic abnormalities. Low-grade chronic inflammation is a related complication recently observed in PCOS. Increased white blood cell (WBC) count was previously reported in PCOS women.<\/jats:p>\n      <jats:p><jats:italic>Objective<\/jats:italic>: To evaluate the effects of six months metformin administration on WBC count in PCOS women.<\/jats:p>\n      <jats:p><jats:italic>Patients and methods<\/jats:italic>: Fifty normal-weight PCOS women without additional metabolic or cardiovascular diseases were enrolled and treated with metformin (850 mg twice daily) for 6 months in a prospective baseline-controlled clinical study. At baseline and after treatment, WBC count and C-reactive protein (CRP) were evaluated in each patient. The whole hormonal profile, serum insulin and glucose levels (at fasting and during a 75 g 2-h oral glucose tolerance test), serum lipid profile were also assessed.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: A significant difference was observed in WBC count (7050 \u00b1 552 vs 6080 \u00b1 577 cell\/mm<jats:sup>3<\/jats:sup> \u00b1 <jats:sc>s.d<\/jats:sc>., <jats:italic>P<\/jats:italic>&lt;0.001) and CRP levels (1.8 \u00b1 0.9 vs 1.1 \u00b1 0.6 mg\/l \u00b1 <jats:sc>s.d<\/jats:sc>., <jats:italic>P<\/jats:italic>&lt;0.001) after metformin treatment in comparison with baseline values. SHBG levels and the free androgen index also changed significantly (<jats:italic>P<\/jats:italic>&lt;0.001). Finally, high-density lipoproteins and the area under curve for glucose\/area under curve for insulin ratio also significantly increased (<jats:italic>P<\/jats:italic>&lt;0.001), whereas low-density lipoproteins and area under curve for insulin were significantly reduced (<jats:italic>P<\/jats:italic>&lt;0.001). No other change was found in any of the biochemical parameters evaluated.<\/jats:p>\n      <jats:p><jats:italic>Conclusion<\/jats:italic>: A six-month course of metformin reduces WBC count in PCOS women.<\/jats:p>","DOI":"10.1530\/eje-07-0133","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T17:25:40Z","timestamp":1183483540000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":35,"title":["Metformin administration improves leukocyte count in women with polycystic ovary syndrome: a 6-month prospective study"],"prefix":"10.1093","volume":"157","author":[{"given":"Francesco","family":"Orio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Manguso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Di Biase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Falbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Giallauria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Labella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Tolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Palomba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/1\/1570069.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/1\/1570069.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:20:12Z","timestamp":1676391612000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/157\/1\/69\/6695904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/eje-07-0133","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}