{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:37:58Z","timestamp":1790865478963,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>: Placental corticotropin-releasing factor (CRF) affects myometrial contractility and the secretion of several uterotonins such as prostaglandins (PGs); however, the activity of CRF is counteracted by CRF-binding protein (CRF-BP). At term and pre-term labor, CRF levels in maternal plasma are highest whereas those of CRF-BP are falling, and the cause of this fall is unknown. Thus, in this study, we investigated the effect of PG administration for labor induction on maternal plasma CRF and CRF-BP concentrations.<\/jats:p>\n      <jats:p><jats:italic>Design<\/jats:italic>: Maternal plasma CRF and CRF-BP levels were assayed before and after (2 h later) induction of labor by intracervical administration of prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>), and at delivery in a group of healthy post-term pregnancies (<jats:italic>n<\/jats:italic>=18). Controls were women at term out of labor (<jats:italic>n<\/jats:italic>=22), who subsequently progressed to deliver a healthy singleton baby.<\/jats:p>\n      <jats:p><jats:italic>Methods<\/jats:italic>: CRF was measured by two-site immunoradiometric assay, and CRF-BP was assayed by radioimmunoassay.<\/jats:p>\n      <jats:p><jats:italic>Results<\/jats:italic>: Maternal plasma CRF levels were significantly (<jats:italic>P<\/jats:italic>&lt;0.0001) lower and CRF-BP significantly (<jats:italic>P<\/jats:italic>&lt;0.0005) higher in post-term than in term pregnancies. With respect to induction of labor, 2 mg PGE<jats:sub>2<\/jats:sub> were sufficient to increase maternal plasma CRF levels at delivery (<jats:italic>P<\/jats:italic>&lt;0.005). While 0.5 mg PGE<jats:sub>2<\/jats:sub> significantly decreased maternal plasma CRF-BP levels at delivery (<jats:italic>P<\/jats:italic>&lt;0.001), 2.0 mg PGE<jats:sub>2<\/jats:sub> significantly reduced CRF-BP concentrations both after 2 h (<jats:italic>P<\/jats:italic>&lt;0.05) and at delivery (<jats:italic>P<\/jats:italic>&lt;0.0001).<\/jats:p>\n      <jats:p><jats:italic>Conclusions<\/jats:italic>: In the light of the well-known stimulation of prostaglandin release by CRF, these data suggest a positive feedback effect of PGE<jats:sub>2<\/jats:sub> on maternal CRF release during induced labor.<\/jats:p>","DOI":"10.1530\/eje-07-0138","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T21:34:22Z","timestamp":1188596062000},"page":"279-284","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["Maternal plasma corticotropin-releasing factor (CRF) and CRF-binding protein (CRF-BP) levels in post-term pregnancy: effect of prostaglandin administration"],"prefix":"10.1093","volume":"157","author":[{"given":"P","family":"Florio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Benedetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Galleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Torricelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Giovannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Battista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F M","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Petraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/3\/1570279.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/3\/1570279.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:20:13Z","timestamp":1676391613000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/157\/3\/279\/6696001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-07-0138","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}