{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:13:46Z","timestamp":1791980026021,"version":"4.4.0"},"reference-count":113,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":["eur j endocrinol"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis, and is the end-product of a carefully orchestrated pattern of expression of signalling molecules and transcription factors leading to the development of this complex organ secreting six hormones from five different cell types. Naturally occurring and transgenic murine models have demonstrated a role for many of these molecules in the aetiology of combined pituitary hormone deficiency (CPHD). These include the transcription factors HESX1, PROP1, POU1F1, LHX3, LHX4, TBX19, SOX2 and SOX3. The expression pattern of these transcription factors dictates the phenotype that results when the gene encoding the relevant transcription factor is mutated. The highly variable phenotype may consist of isolated hypopituitarism, or more complex disorders such as septo-optic dysplasia and holoprosencephaly. Since mutations in any one transcription factor are uncommon, and since the overall incidence of mutations in known transcription factors is low in patients with CPHD, it is clear that many genes remain to be identified, and the characterization of these will further elucidate the pathogenesis of these complex conditions and also shed light on normal pituitary development.<\/jats:p>","DOI":"10.1530\/eje-07-0156","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T21:38:54Z","timestamp":1188941934000},"page":"S3-S14","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":72,"title":["Hypothalamic and pituitary development: novel insights into the aetiology"],"prefix":"10.1093","volume":"157","author":[{"given":"Daniel","family":"Kelberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul Tulsidas","family":"Dattani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_29324985","first-page":"4840","volume":"12523","year":"1998","journal-title":"Development","ISSN":"https:\/\/id.crossref.org\/issn\/0950-1991","issn-type":"print"},{"issue":"6","key":"2_6406376","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/S0955-0674(99)00034-4","volume":"11","author":"Dosen","year":"1999","journal-title":"Current opinion in cell biology","ISSN":"https:\/\/id.crossref.org\/issn\/0955-0674","issn-type":"print"},{"issue":"1","key":"3_11093711","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1146\/annurev.neuro.24.1.327","volume":"24","author":"Dasen","year":"2001","journal-title":"Annual review of neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0147-006X","issn-type":"print"},{"key":"4_29324986","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11154-005-3047-7","volume":"6","year":"2005","journal-title":"REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS"},{"key":"5_29324987","first-page":"309","volume":"74","year":"1954","journal-title":"SCHWEIZER ARCHIV FUR NEUROLOGIE UND PSYCHIATRIE"},{"key":"6_29324988","first-page":"61","volume":"69","year":"1941","journal-title":"BULLETIN OF THE JOHNS HOPKINS HOSPITAL"},{"issue":"7652","key":"7_11529482","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(70)91717-4","volume":"1","author":"Hoyt","year":"1970","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"2","key":"8_32184534","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1530\/acta.0.1070282","volume":"107","author":"Arslanian","year":"1984","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"2","key":"9_13176983","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1136\/adc.59.2.111","volume":"59","author":"Stanhope","year":"1984","journal-title":"Archives of Disease in Childhood","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9888","issn-type":"print"},{"issue":"1","key":"10_21512238","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jpeds.2005.07.031","volume":"148","author":"Patel","year":"2006","journal-title":"The Journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"key":"11_29324989","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0387-7604(86)80075-4","volume":"8","year":"1986","journal-title":"BRAIN AND DEVELOPMENT"},{"issue":"2","key":"12_23074373","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1210\/jc.2006-1609","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"13_8662449","first-page":"425","volume":"79","author":"Acers","year":"1981","journal-title":"Transactions of the American Ophthalmological Society","ISSN":"https:\/\/id.crossref.org\/issn\/0065-9533","issn-type":"print"},{"issue":"11","key":"14_13335728","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1177\/000992288402301105","volume":"23","author":"Izenberg","year":"1984","journal-title":"Clinical Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9228","issn-type":"print"},{"issue":"5","key":"15_14238715","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/00005072-198709000-00008","volume":"46","author":"Roessmann","year":"1987","journal-title":"Journal of neuropathology and experimental neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3069","issn-type":"print"},{"key":"16_8004398","first-page":"273","volume":"103","author":"Zaias","year":"1978","journal-title":"Transactions of the American Neurological Association","ISSN":"https:\/\/id.crossref.org\/issn\/0065-9479","issn-type":"print"},{"issue":"3","key":"17_16285664","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1651-2227.1996.tb14044.x","volume":"85","author":"Wales","year":"1996","journal-title":"Acta paediatrica (Oslo, Norway : 1992)","ISSN":"https:\/\/id.crossref.org\/issn\/0365-1436","issn-type":"print"},{"issue":"1","key":"18_13527907","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/ajmg.1320210118","volume":"21","author":"Blethen","year":"1985","journal-title":"American journal of medical genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0148-7299","issn-type":"print"},{"issue":"6","key":"19_5652753","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0002-9394(14)72430-4","volume":"109","author":"Benner","year":"1990","journal-title":"American journal of ophthalmology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9394","issn-type":"print"},{"issue":"1","key":"20_11018242","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/hmg\/10.1.39","volume":"10","author":"Thomas","year":"2001","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"10","key":"21_17856316","doi-asserted-by":"publisher","first-page":"4832","DOI":"10.1210\/jc.2002-021868","volume":"88","author":"Cohen","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"22_17466175","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1210\/jc.2002-020818","volume":"88","author":"Tajima","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"23_15788764","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1074\/jbc.270.8.3869","volume":"270","author":"Thomas","year":"1995","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"23","key":"24_11421179","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1101\/gad.932601","volume":"15","author":"Dasen","year":"2001","journal-title":"Genes &amp; Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"key":"25_28517723","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1242\/dev.128.24.5189","volume":"128","year":"2001","journal-title":"Development","ISSN":"https:\/\/id.crossref.org\/issn\/0950-1991","issn-type":"print"},{"issue":"2","key":"26_6033275","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/477","volume":"19","author":"Dattani","year":"1998","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"5","key":"27_18825062","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/humu.9332","volume":"25","author":"Sobrier","year":"2005","journal-title":"Human mutation","ISSN":"https:\/\/id.crossref.org\/issn\/1059-7794","issn-type":"print"},{"issue":"11","key":"28_22547393","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1210\/jc.2006-0426","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"29_17095540","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1034\/j.1600-0420.2002.800313.x","volume":"80","author":"Tornqvist","year":"2002","journal-title":"Acta ophthalmologica Scandinavica","ISSN":"https:\/\/id.crossref.org\/issn\/1395-3907","issn-type":"print"},{"issue":"12","key":"30_14591631","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1093\/hmg\/2.12.2013","volume":"2","author":"Stevanovlc","year":"1993","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"3","key":"31_16852133","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S0959-437X(97)80147-5","volume":"7","author":"Pevny","year":"1997","journal-title":"Current opinion in genetics &amp; development","ISSN":"https:\/\/id.crossref.org\/issn\/0959-437X","issn-type":"print"},{"issue":"13","key":"32_6025683","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.125.13.2521","volume":"125","author":"Kamachi","year":"1998","journal-title":"Development","ISSN":"https:\/\/id.crossref.org\/issn\/0950-1991","issn-type":"print"},{"issue":"1","key":"33_21733072","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.conb.2005.01.016","volume":"15","author":"Pevny","year":"2005","journal-title":"Current opinion in neurobiology","ISSN":"https:\/\/id.crossref.org\/issn\/0959-4388","issn-type":"print"},{"issue":"3","key":"34_18060820","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/ng1309","volume":"36","author":"Rizzoti","year":"2004","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"22","key":"35_17881958","doi-asserted-by":"publisher","first-page":"8084","DOI":"10.1128\/MCB.23.22.8084-8091.2003","volume":"23","author":"Weiss","year":"2003","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"1","key":"36_16418405","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/(SICI)1096-8628(19960712)64:1<35::AID-AJMG5>3.0.CO;2-Q","volume":"64","author":"Hamel","year":"1996","journal-title":"American journal of medical genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0148-7299","issn-type":"print"},{"issue":"4","key":"37_16750366","first-page":"910","volume":"60","author":"Lagerstr\u00a0\u00a0m-Ferm\u00a0\u00a0r","year":"1997","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"2","key":"38_10511747","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1006\/geno.2000.6327","volume":"69","author":"Hol","year":"2000","journal-title":"Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/0888-7543","issn-type":"print"},{"issue":"4","key":"39_17001987","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1006\/geno.2002.6741","volume":"79","author":"Solomon","year":"2002","journal-title":"Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/0888-7543","issn-type":"print"},{"key":"40_29324990","first-page":"11","volume":"138","year":"2005","journal-title":"AMERICAN JOURNAL OF MEDICAL GENETICS PART A"},{"issue":"5","key":"41_18775053","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1086\/430134","volume":"76","author":"Woods","year":"2005","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"6","key":"42_17348792","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1086\/344661","volume":"71","author":"Laumonnier","year":"2002","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"20","key":"43_18446360","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1093\/hmg\/ddh277","volume":"13","year":"2004","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"1-2","key":"44_10926868","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0925-4773(99)00116-1","volume":"86","author":"Wood","year":"1999","journal-title":"Mechanisms of development","ISSN":"https:\/\/id.crossref.org\/issn\/0925-4773","issn-type":"print"},{"issue":"9","key":"45_21796167","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1093\/hmg\/ddl064","volume":"15","year":"2006","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"1","key":"46_17463897","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1101\/gad.224503","volume":"17","author":"Avilion","year":"2003","journal-title":"Genes &amp; Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"issue":"9","key":"47_21965641","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1101\/gad.1407906","volume":"20","author":"Taranova","year":"2006","journal-title":"Genes &amp; Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"issue":"9","key":"48_22532799","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1172\/JCI28658","volume":"116","year":"2006","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"4","key":"49_17561494","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/ng1120","volume":"33","author":"Fantes","year":"2003","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"50_29324991","first-page":"1","volume":"135","year":"2005","journal-title":"AMERICAN JOURNAL OF MEDICAL GENETICS PART A"},{"key":"51_29324992","first-page":"95","volume":"138","year":"2005","journal-title":"AMERICAN JOURNAL OF MEDICAL GENETICS PART A"},{"issue":"6","key":"52_19599619","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1399-0004.2005.00518.x","volume":"68","author":"Zenteno","year":"2005","journal-title":"Clinical genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9163","issn-type":"print"},{"issue":"2","key":"53_23607678","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1530\/EJE-06-0606","volume":"156","author":"Sato","year":"2007","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"7","key":"54_15830669","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1073\/pnas.92.7.2720","volume":"92","author":"Bach","year":"1995","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"55_10402431","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1006\/bbrc.2000.3038","volume":"274","author":"Schmitt","year":"2000","journal-title":"Biochemical and biophysical research communications","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"issue":"4","key":"56_15957396","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/aja.1002020405","volume":"202","author":"Zhadanov","year":"1995","journal-title":"Developmental dynamics : an official publication of the American Association of Anatomists","ISSN":"https:\/\/id.crossref.org\/issn\/1058-8388","issn-type":"print"},{"issue":"5264","key":"57_16215125","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1126\/science.272.5264.1004","volume":"272","author":"Sheng","year":"1996","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"58_29324993","first-page":"B132","volume":"186","year":"1997","journal-title":"Developmental biology","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1606","issn-type":"print"},{"issue":"2","key":"59_10338537","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/76041","volume":"25","author":"Netchine","year":"2000","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"1-2","key":"60_11074747","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0378-1119(01)00369-9","volume":"265","author":"Sloop","year":"2001","journal-title":"Gene","ISSN":"https:\/\/id.crossref.org\/issn\/0378-1119","issn-type":"print"},{"issue":"3","key":"61_21342881","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1210\/jc.2005-2360","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"62_29324994","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.modgep.2004.07.003","volume":"5","year":"2004","journal-title":"GENE EXPRESSION PATTERNS"},{"issue":"5","key":"63_23695399","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1210\/jc.2006-2177","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5344","key":"64_5814615","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1126\/science.278.5344.1809","volume":"278","author":"Sheng","year":"1997","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"5","key":"65_11348758","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1086\/323764","volume":"69","author":"Machinis","year":"2001","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"6","key":"66_11099978","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0092-8674(01)00282-3","volume":"104","author":"Lamolet","year":"2001","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"15","key":"67_19671361","doi-asserted-by":"publisher","first-page":"8674","DOI":"10.1073\/pnas.141234898","volume":"98","year":"2001","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"6","key":"68_17550587","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1101\/gad.1065703","volume":"17","year":"2003","journal-title":"Genes &amp; Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"issue":"6","key":"69_17550583","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1101\/gad.1065603","volume":"17","year":"2003","journal-title":"Genes &amp; Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"issue":"3","key":"70_18727618","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1210\/jc.2004-1300","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"71_18467172","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1530\/eje.0.1510463","volume":"151","author":"Metherell","year":"2004","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"2","key":"72_21338516","doi-asserted-by":"publisher","first-page":"e322","DOI":"10.1542\/peds.2005-1973","volume":"117","year":"2006","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"issue":"6607","key":"73_16526242","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/384327a0","volume":"384","author":"Sornson","year":"1996","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"1","key":"74_16162587","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1242\/dev.122.1.151","volume":"122","author":"Gage","year":"1996","journal-title":"Development","ISSN":"https:\/\/id.crossref.org\/issn\/0950-1991","issn-type":"print"},{"issue":"6","key":"75_10252136","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1210\/en.132.6.2518","volume":"132","author":"Tang","year":"1993","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"2","key":"76_5882499","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/ng0298-147","volume":"18","author":"Wu","year":"1998","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"5","key":"77_10816144","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1210\/jc.84.5.1645","volume":"84","author":"Deladoey","year":"1999","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"9","key":"78_6158027","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1210\/jc.83.9.3346","volume":"83","author":"Cogan","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"79_18929455","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1365-2265.2005.02291.x","volume":"63","author":"Turton","year":"2005","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"3","key":"80_6235501","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/S0014-5793(98)01234-4","volume":"437","author":"Duquesnoy","year":"1998","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3468","issn-type":"print"},{"issue":"11","key":"81_18511462","doi-asserted-by":"publisher","first-page":"5779","DOI":"10.1210\/jc.2003-032124","volume":"89","author":"Reynaud","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"82_10435608","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1210\/jc.85.8.2779","volume":"85","author":"Osorio","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"83_19380367","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1530\/eje.1.01989","volume":"153","author":"Lebl","year":"2005","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"9","key":"84_6158027","first-page":"3346","volume":"83","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"85_19316689","doi-asserted-by":"publisher","first-page":"4880","DOI":"10.1210\/jc.2005-0119","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"86_17176910","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1046\/j.1365-2265.2002.01550.x","volume":"57","author":"Arroyo","year":"2002","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"10","key":"87_6178713","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1210\/jc.83.10.3727","volume":"83","author":"Fluck","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"9","key":"88_11313122","doi-asserted-by":"publisher","first-page":"4529","DOI":"10.1210\/jc.86.9.4529","volume":"86","author":"Vallette-Kasic","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"89_10754948","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1210\/jc.84.3.942","volume":"84","author":"Mendonca","year":"1999","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"90_10503712","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1530\/eje.0.1430347","volume":"143","author":"Asteria","year":"2000","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"1","key":"91_6431944","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1210\/jc.85.1.390","volume":"85","author":"Pernasetti","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"9","key":"92_11313096","doi-asserted-by":"publisher","first-page":"4353","DOI":"10.1210\/jc.86.9.4353","volume":"86","author":"Riepe","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"10","key":"93_18463542","doi-asserted-by":"publisher","first-page":"5256","DOI":"10.1210\/jc.2004-0661","volume":"89","author":"Bottner","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"12","key":"94_10586438","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.1210\/jc.85.12.4556","volume":"85","author":"Agarwal","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"95_6454400","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2214\/ajr.174.2.1740555","volume":"174","author":"Fofanova","year":"2000","journal-title":"American Journal of Roentgenology","ISSN":"https:\/\/id.crossref.org\/issn\/0361-803X","issn-type":"print"},{"issue":"5","key":"96_18169045","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1210\/jc.2003-031765","volume":"89","author":"Voutetakis","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"11","key":"98_11162723","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1093\/hmg\/10.11.1141","volume":"10","author":"Cushman","year":"2001","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"3","key":"99_5045009","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0092-8674(88)90037-2","volume":"55","author":"Bodner","year":"1988","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"1","key":"100_11029095","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1210\/er.22.1.2","volume":"22","author":"Andersen","year":"2001","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"5","key":"101_15760199","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/0959-437X(94)90138-S","volume":"4","author":"Rhodes","year":"1994","journal-title":"Current opinion in genetics &amp; development","ISSN":"https:\/\/id.crossref.org\/issn\/0959-437X","issn-type":"print"},{"issue":"6293","key":"102_9191515","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/347528a0","volume":"347","author":"Li","year":"1990","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"47","key":"103_15662243","doi-asserted-by":"crossref","first-page":"29335","DOI":"10.1016\/S0021-9258(18)43877-X","volume":"269","author":"Andersen","year":"1994","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"6","key":"104_10252369","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1101\/gad.7.6.913","volume":"7","author":"Rhodes","year":"1993","journal-title":"Genes &amp; Development","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"issue":"1","key":"105_10224097","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/ng0492-56","volume":"1","author":"Tatsumi","year":"1992","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"2","key":"106_15763460","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1210\/jc.80.2.679","volume":"80","author":"Cohen","year":"1995","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5073","key":"107_9943568","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1126\/science.257.5073.1115","volume":"257","author":"Radovick","year":"1992","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"6","key":"108_17648984","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1530\/eje.0.1480619","volume":"148","author":"Kishimoto","year":"2003","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"5073","key":"109_9943569","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1126\/science.257.5073.1118","volume":"257","author":"Pfaffle","year":"1992","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"110_29324995","first-page":"1","volume":"105","year":"1997","journal-title":"EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY AND DIABETES"},{"issue":"8","key":"111_19338736","doi-asserted-by":"publisher","first-page":"4762","DOI":"10.1210\/jc.2005-0570","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"112_17215214","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1210\/er.2001-0030","volume":"23","author":"Cohen","year":"2002","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"8","key":"113_17859907","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1172\/JCI200318589","volume":"112","author":"Carvalho","year":"2003","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"114_29324996","first-page":"27","volume":"20","year":"2007","journal-title":"JOURNAL OF PEDIATRIC ENDOCRINOLOGY AND METABOLISM"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/suppl_1\/1570003.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/157\/suppl_1\/1570003.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:20:17Z","timestamp":1676391617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/157\/Supplement_1\/S3\/6705584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":113,"journal-issue":{"issue":"suppl_1"},"URL":"https:\/\/doi.org\/10.1530\/eje-07-0156","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}