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The disfiguring changes to the eyes and face can have a direct effect upon psychological health, while physical aspects of the disease such as altered visual acuity, diplopia, orbital pain and lacrimation may influence psychological function as a secondary phenomenon, due to interference with daily living. Evidence appears to confirm the anecdotal impression of many clinicians dealing with GO patients that the prevalence of psychological morbidity in this patient group is high. A \u2018biopsychosocial\u2019 approach to care that addresses biological and psychosocial functioning as major determinants of health is an appropriate strategy when treating patients with GO.<\/jats:p>","DOI":"10.1530\/eje-07-0205","type":"journal-article","created":{"date-parts":[[2007,7,26]],"date-time":"2007-07-26T17:18:20Z","timestamp":1185470300000},"page":"127-131","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":93,"title":["Psychological implications of Graves\u2019 orbitopathy"],"prefix":"10.1093","volume":"157","author":[{"given":"I","family":"Coulter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Frewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G 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