{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:01:06Z","timestamp":1761512466311},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The impact of the aetiology of childhood-onset GH deficiency (CO-GHD) on the clinical presentation during adulthood and the response to GH replacement has been poorly defined. Our study aims to characterize CO-GHD in adults due to different aetiologies and evaluate the effect of 2 years of GH replacement therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Data from 353 adults with CO-GHD from Pfizer International Metabolic Database KIMS were retrospectively grouped according to GHD aetiology: non-organic disorder (<jats:italic>n<\/jats:italic>=147), organic pituitary disease (<jats:italic>n<\/jats:italic>=159), and brain tumour (<jats:italic>n<\/jats:italic>=47). Extent of pituitary dysfunction, IGF-I concentration, lipid concentrations and quality-of-life (QoL) were assessed at baseline and after 2 years of GH replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GHD was diagnosed at a later age in the organic pituitary group than in the other groups, resulting in a shorter duration of GH treatment during childhood. However, the final height was greater in the organic pituitary group. Panhypopituitarism was most common in the non-organic disorder and in the organic pituitary groups, while isolated GHD was more prominent in the brain tumour group. Serum IGF-I levels were the lowest in the non-organic group. QoL was the poorest in the brain tumour group. Lipid profile and QoL improved significantly during GH replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The adverse consequences of CO-GHD in adulthood vary between aetiologies, but improve similarly with GH treatment. It is, therefore, important to consider retesting all patients with CO-GHD in early adulthood and, if persistent severe GHD is confirmed, recommence GH replacement.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-07-0364","type":"journal-article","created":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T20:49:43Z","timestamp":1194295783000},"page":"589-596","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":14,"title":["Impact of the primary aetiology upon the clinical outcome of adults with childhood-onset GH deficiency"],"prefix":"10.1093","volume":"157","author":[{"given":"Charlotte","family":"Hoybye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"1KIGS\/KIMS\/ACROSTUDY Medical OutcomesPfizer Endocrine Care, Sollentuna, Sweden,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P","family":"Monson","sequence":"additional","affiliation":[{"name":"2Centre for Clinical EndocrinologyWilliam Harvey Research Institute, St Bartholomew's Hospital, Queen Mary University of London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ko\u0142towska-H\u00e4ggstr\u00f6m","sequence":"additional","affiliation":[{"name":"1KIGS\/KIMS\/ACROSTUDY Medical OutcomesPfizer Endocrine Care, Sollentuna, Sweden,"},{"name":"3Department of PharmacyUppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e1clav","family":"H\u00e1na","sequence":"additional","affiliation":[{"name":"4Third Department of Internal MedicineCharles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell","family":"Geffner","sequence":"additional","affiliation":[{"name":"4Third Department of Internal MedicineCharles University, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Abs","sequence":"additional","affiliation":[{"name":"6University HospitalAntwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"2","key":"2_5888242","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1210\/jc.83.2.382","volume":"83","author":"Carroll","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; 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