{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:33:06Z","timestamp":1772793186931,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>GH deficiency (GHD) in adults is associated with adverse effects on metabolism and increased cardiovascular risk. Pregnancy-associated plasma protein-A (PAPP-A) is a protease that promotes IGF-I availability in vascular tissues. PAPP-A levels appear to correlate with carotid intima-media thickness and have been proposed as an early predictor of cardiac events. The aim of our study was to evaluate PAPP-A levels in GHD adults at baseline and after GH replacement and correlate them with changes in body composition, lipid profile, glucose homeostasis, inflammatory markers and in leptin and adiponectin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Fourteen GHD adults were evaluated at baseline and after 1 year of GH therapy. All patients were compared at baseline with 28 age-, sex- and body mass index (BMI)-matched control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, GHD adults showed higher PAPP-A levels (<jats:italic>P<\/jats:italic>=0.03) and higher leptin (<jats:italic>P<\/jats:italic>=0.04), fibrinogen (<jats:italic>P<\/jats:italic>=0.002) and highly sensitive C-reactive protein (<jats:italic>P<\/jats:italic>=0.01) values than controls. Therapy with GH reduced PAPP-A (<jats:italic>P<\/jats:italic>=0.03) and fibrinogen levels (<jats:italic>P<\/jats:italic>=0.002) while increased BMI (<jats:italic>P<\/jats:italic>=0.01) and reduced waist-hip ratio (WHR; <jats:italic>P<\/jats:italic>=0.05) were observed. Insulin and homeostasis model assessment of insulin resistance index increased after treatment (<jats:italic>P<\/jats:italic>&lt;0.004\/<jats:italic>P<\/jats:italic>=0.007), without changes in leptin or adiponectin levels. PAPP-A values correlated positively with BMI and WHR and negatively with adiponectin before and after treatment, with no correlation with glucose homeostasis parameters, lipid profile or leptin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that PAPP-A expression is increased in GHD adults, and that 1 year of GH replacement therapy is able to reduce PAPP-A levels in this population. However, further studies are required to determine whether this decrease correlates with an improvement in atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-07-0554","type":"journal-article","created":{"date-parts":[[2008,3,24]],"date-time":"2008-03-24T20:38:31Z","timestamp":1206391111000},"page":"483-490","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":33,"title":["Effects of GH treatment in GH-deficient adults on adiponectin, leptin and pregnancy-associated plasma protein-A."],"prefix":"10.1093","volume":"158","author":[{"given":"C","family":"Joaquin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Granada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sanmart\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"5","key":"1_18169023","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1210\/jc.2003-030346","volume":"89","author":"Hoffman","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"2_6326908","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1046\/j.1365-2265.1998.00634.x","volume":"49","author":"Badia","year":"1998","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"4","key":"3_18111428","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/j.1365-2265.2004.02000.x","volume":"60","author":"Hana","year":"2004","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"5","key":"4_6381733","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1530\/eje.0.1410481","volume":"141","author":"Sanmarti","year":"1999","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"4","key":"5_18786936","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1530\/eje.1.01881","volume":"152","author":"Kelestimur","year":"2005","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"1","key":"6_21626830","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1055\/s-2006-924970","volume":"38","author":"Benedini","year":"2006","journal-title":"Hormone and metabolic research. 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