{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T02:03:57Z","timestamp":1746410637372},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>IGF binding protein-1 (IGFBP-1) is essential for IGF-I bioavailability. High levels of IGFBP-1 are encountered in critically ill patients and are a good predictor marker in acute myocardial infarction. The mechanisms responsible for the elevated IGFBP-1 levels in these conditions are still unclear. Interestingly, high levels of vasopressin have been reported in the above-mentioned conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the effect of vasopressin on IGFBP-1 in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Placebo-controlled cross-over study in patients with central diabetes insipidus (CDI) in whom potential interference from endogenous vasopressin secretion is minimized. After a 3-day desmopressin washout period, each patient received i.v. saline on day 1 and desmopressin (3\u200a\u03bcg) on day 2. Blood samples were taken after administration, every 2\u200ah during the whole night, starting at 2000\u200ah.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and setting<\/jats:title><jats:p>Fourteen inpatients with CDI in an endocrinology department of a university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IGFBP-1 increased within 4\u200ah after 1-desamino-8-<jats:sc>d<\/jats:sc>-arginine vasopressin (DDAVP) by 375\u00b173%, compared with a spontaneous fasting increase by 252\u00b146% following placebo administration (<jats:italic>P<\/jats:italic>&lt;0.05). No changes were registered in the levels of either classically regulators of IGFBP-1 (insulin, glucagon, and cortisol) or of IGF-I and glucose. The decrease in plasma osmolarity induced by DDAVP did not precede the increase in IGFBP-1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DDAVP increases serum levels of IGFBP-1. Further investigation is essential to unravel the clinical potential of this interaction in conditions associated with high IGFBP-1 levels.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-07-0662","type":"journal-article","created":{"date-parts":[[2008,3,24]],"date-time":"2008-03-24T20:38:31Z","timestamp":1206391111000},"page":"479-482","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Desmopressin increases IGF-binding protein-1 in humans."],"prefix":"10.1093","volume":"158","author":[{"given":"S B","family":"Catrina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Rotarus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I R","family":"Botusan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Coculescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Brismar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"3","key":"1_45905328","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3181\/00379727-216-44182","volume":"216","author":"Lee","year":"1997","journal-title":"Experimental Biology and Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/1535-3702","issn-type":"print"},{"issue":"3","key":"2_15596172","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1210\/jc.79.3.872","volume":"79","author":"Brismar","year":"1994","journal-title":"Journal of Clinical Endocrinology &amp; 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