{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:29Z","timestamp":1787022809796,"version":"build-2736575974"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Adrenal cortical carcinoma (ACC) is an aggressive tumour with a high mortality. We describe six patients living 12\u201328 years despite recurrent and\/or metastatic ACC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>\n                      The first patient presented in 1979 with an ACC of 8\u200acm. After resection, she developed seven recurrences for which she was treated with resection and\/or mitotane (\n                      <jats:italic>o<\/jats:italic>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2032-DDD) treatment. The patient is still alive 28 years after diagnosis. The second patient presented with an ACC of 9\u200acm. After resection, the patient developed liver metastases, which were treated with\n                      <jats:italic>o<\/jats:italic>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2032-DDD. The patient is still alive 25 years after diagnosis. The third patient presented with an ACC of 12\u200acm. The tumour was resected followed by\n                      <jats:italic>o<\/jats:italic>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2032-DDD treatment. She had a local recurrence that was completely resected. She is still alive 18 years after diagnosis. The fourth patient presented with an ACC of 14\u200acm. After resection, adjuvant\n                      <jats:italic>o<\/jats:italic>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2032-DDD was started. Subsequently, the patient developed two recurrences, which were resected. He is still alive 17 years after the initial diagnosis. The fifth patient presented with an ACC of 10\u200acm. After diagnosis, she developed lung metastasis, which were treated with\n                      <jats:italic>o<\/jats:italic>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2032-DDD and chemotherapy. The patient is still alive with slowly progressive disease 12 years after diagnosis. The sixth patient presented with an ACC of 7\u200acm. After resection, she developed four recurrences, which were resected. The patient is still alive 28 years after diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Some patients can have an extremely long survival of ACC, despite recurrent disease and metastases. The mainstay of therapy in our patients was repeated surgery and\n                      <jats:italic>o<\/jats:italic>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2032-DDD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-07-0723","type":"journal-article","created":{"date-parts":[[2008,5,27]],"date-time":"2008-05-27T13:53:05Z","timestamp":1211896385000},"page":"911-919","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":36,"title":["Extremely long survival in six patients despite recurrent and metastatic adrenal carcinoma."],"prefix":"10.1093","volume":"158","author":[{"given":"I G C","family":"Hermsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Gelderblom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kievit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Romijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H R","family":"Haak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_31121073","first-page":"613","volume":"109","year":"1958","journal-title":"Annals of the Royal College of Surgeons of England","ISSN":"https:\/\/id.crossref.org\/issn\/0035-8843","issn-type":"print"},{"issue":"6","key":"2_21809127","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1210\/jc.2005-2639","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"3_30503641","first-page":"386","volume":"6","year":"2005","journal-title":"CURRENT OPINION IN INVESTIGATIONAL DRUGS"},{"issue":"1","key":"4_27977927","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1677\/erc.1.01130","volume":"14","author":"Libe","year":"2007","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"23","key":"5_28788020","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1056\/NEJMoa063360","volume":"356","author":"Terzolo","year":"2007","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"17","key":"6_5607261","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1056\/NEJM199004263221705","volume":"322","author":"Luton","year":"1990","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"7","key":"7_11333695","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s00268-001-0047-y","volume":"25","author":"Icard","year":"2001","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"2","key":"8_16175097","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0039-6060(96)80164-4","volume":"119","author":"Crucitti","year":"1996","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"1","key":"9_10766165","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s003450050101","volume":"17","author":"Schulick","year":"1999","journal-title":"World journal of urology","ISSN":"https:\/\/id.crossref.org\/issn\/0724-4983","issn-type":"print"},{"issue":"3","key":"10_5307361","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1002\/1097-0142(19890801)64:3<765::AID-CNCR2820640333>3.0.CO;2-I","volume":"64","author":"Venkatesh","year":"1989","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"6","key":"11_10062230","first-page":"963","volume":"112","author":"Pommier","year":"1992","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"5","key":"12_15486340","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/bjc.1994.183","volume":"69","author":"Haak","year":"1994","journal-title":"British Journal of Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1532-1827","issn-type":"print"},{"issue":"5","key":"13_11332401","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/1097-0142(20010901)92:5<1113::AID-CNCR1428>3.0.CO;2-I","volume":"92","author":"Vassilopoulou-Sellin","year":"2001","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"3-4","key":"14_10083513","first-page":"161","volume":"41","author":"van Aalderen","year":"1992","journal-title":"The Netherlands journal of medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0300-2977","issn-type":"print"},{"issue":"1","key":"15_15943886","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1442-2042.1995.tb00621.x","volume":"2","author":"Sakamoto","year":"1995","journal-title":"International journal of urology : official journal of the Japanese Urological Association","ISSN":"https:\/\/id.crossref.org\/issn\/0919-8172","issn-type":"print"},{"issue":"7","key":"16_11282336","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/BF03343888","volume":"24","author":"Ilias","year":"2001","journal-title":"Journal of endocrinological investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0391-4097","issn-type":"print"},{"issue":"10","key":"17_17269617","doi-asserted-by":"publisher","first-page":"4452","DOI":"10.1210\/jc.2001-011978","volume":"87","author":"De Leon","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3C","key":"18_17773485","first-page":"2929","volume":"23","author":"Orlando","year":"2003","journal-title":"Anticancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0250-7005","issn-type":"print"},{"issue":"2","key":"19_28500265","first-page":"1045","volume":"27","author":"MEYER","year":"2007","journal-title":"Anticancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0250-7005","issn-type":"print"},{"issue":"5","key":"20_17521566","doi-asserted-by":"crossref","first-page":"424","DOI":"10.7326\/0003-4819-138-5-200303040-00013","volume":"138","author":"Grumbach","year":"2003","journal-title":"Annals of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"issue":"3","key":"21_11289978","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1530\/eje.0.1450335","volume":"145","author":"Wachenfeld","year":"2001","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"8","key":"22_17768484","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1097\/01.MP.0000081730.72305.81","volume":"16","author":"Stojadinovic","year":"2003","journal-title":"Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc","ISSN":"https:\/\/id.crossref.org\/issn\/0893-3952","issn-type":"print"},{"issue":"1","key":"23_22874431","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1210\/jc.2006-0706","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"24_31121075","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.surg.2007.09.006","volume":"142","year":"2007","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"6","key":"25_9658122","first-page":"1006","volume":"110","author":"Decker","year":"1991","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"11","key":"26_14518593","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1002\/1097-0142(19931201)72:11<3145::AID-CNCR2820721105>3.0.CO;2-N","volume":"72","author":"Wooten","year":"1993","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"6","key":"27_5820957","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1159\/000227608","volume":"54","author":"Barzon","year":"1997","journal-title":"Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0030-2414","issn-type":"print"},{"issue":"5","key":"28_6493743","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1159::AID-CNCR28>3.0.CO;2-R","volume":"88","author":"Williamson","year":"2000","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"29_31121077","first-page":"371","volume":"96","year":"1984","journal-title":"Medizinische Klinik","ISSN":"https:\/\/id.crossref.org\/issn\/0025-8458","issn-type":"print"},{"issue":"10","key":"30_10231733","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1002\/1097-0142(19930515)71:10<3119::AID-CNCR2820711037>3.0.CO;2-8","volume":"71","author":"Vassilopoulou-Sellin","year":"1993","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"6","key":"31_11440950","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1002\/1097-0142(20010915)92:6<1385::AID-CNCR1461>3.0.CO;2-2","volume":"92","author":"Baudin","year":"2001","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"32_31121080","first-page":"377","volume":"67","year":"1983","journal-title":"Cancer treatment and research","ISSN":"https:\/\/id.crossref.org\/issn\/0927-3042","issn-type":"print"},{"issue":"12","key":"33_9473596","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1002\/1097-0142(19910615)67:12<2997::AID-CNCR2820671211>3.0.CO;2-#","volume":"67","author":"Schlumberger","year":"1991","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"1","key":"34_10089728","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1200\/JCO.1993.11.1.161","volume":"11","author":"Bukowski","year":"1993","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"4","key":"35_6127115","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/bjc.1998.530","volume":"78","author":"Bonacci","year":"1998","journal-title":"British Journal of Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1532-1827","issn-type":"print"},{"issue":"10","key":"36_10571783","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1023\/A:1008377915129","volume":"11","author":"Khan","year":"2000","journal-title":"Annals of Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0923-7534","issn-type":"print"},{"issue":"11","key":"37_17318076","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1093\/annonc\/mdf291","volume":"13","author":"Baudin","year":"2002","journal-title":"Annals of Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0923-7534","issn-type":"print"},{"issue":"9","key":"38_17065971","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1002\/cncr.10487","volume":"94","author":"Abraham","year":"2002","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"2","key":"39_18286495","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1385\/MO:21:2:167","volume":"21","author":"Khan","year":"2004","journal-title":"Medical oncology (Northwood, London, England)","ISSN":"https:\/\/id.crossref.org\/issn\/1357-0560","issn-type":"print"},{"issue":"3","key":"40_19492744","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1677\/erc.1.01025","volume":"12","author":"Berruti","year":"2005","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"4","key":"41_8976205","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/1097-0142(19830815)52:4<707::AID-CNCR2820520424>3.0.CO;2-N","volume":"52","author":"Nader","year":"1983","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"issue":"6","key":"42_6012209","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s002689900442","volume":"22","author":"Khorram-Manesh","year":"1998","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"2","key":"43_10730170","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1001\/archsurg.134.2.181","volume":"134","author":"Harrison","year":"1999","journal-title":"Archives of Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0004-0010","issn-type":"print"},{"issue":"8","key":"44_6420914","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s10434-999-0719-7","volume":"6","author":"Schulick","year":"1999","journal-title":"Annals of Surgical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1068-9265","issn-type":"print"},{"issue":"5","key":"45_11145212","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1001\/archsurg.136.5.543","volume":"136","author":"Kendrick","year":"2001","journal-title":"Archives of Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0004-0010","issn-type":"print"},{"key":"46_28003226","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0277-5379(84)90033-6","volume":"20","year":"1984","journal-title":"EUROPEAN JOURNAL OF CANCER AND CLINICAL ONCOLOGY"},{"issue":"9","key":"47_6157985","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1210\/jc.83.9.3100","volume":"83","author":"Dickstein","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"48_16100180","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/S0039-6060(05)80119-9","volume":"118","author":"Lee","year":"1995","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"4","key":"49_10008073","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/BF02067377","volume":"16","author":"Icard","year":"1992","journal-title":"World journal of surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"issue":"6","key":"50_5849825","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/S0039-6060(97)90229-4","volume":"122","author":"Bellantone","year":"1997","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"11","key":"51_22458382","doi-asserted-by":"publisher","first-page":"4501","DOI":"10.1210\/jc.2006-1007","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"52_18115016","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1148\/radiol.2311031007","volume":"231","year":"2004","journal-title":"Radiology","ISSN":"https:\/\/id.crossref.org\/issn\/0033-8419","issn-type":"print"},{"issue":"3","key":"53_17479903","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/cncr.11084","volume":"97","author":"Wood","year":"2003","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/158\/6\/911.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/158\/6\/911.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:21:18Z","timestamp":1676373678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/158\/6\/911\/6676001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":53,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-07-0723","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}