{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:48:01Z","timestamp":1761518881618},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Ectopic adrenocorticotropin secretion (EAS) remains a therapeutic challenge whenever the tumor responsible for the syndrome is not amenable to curative resection. Two cases of EAS related to metastatic foregut-derived endocrine carcinomas led us to use mifepristone, an antagonist of both progesterone and glucocorticoids. Mifepristone clearly improved skin lesions and diabetes associated with hypercorticism. The beneficial effect lasted for about 10 months. In both cases, recurrent hypertension and hypokalemia eventually required adrenalectomy.<\/jats:p>","DOI":"10.1530\/eje-07-0792","type":"journal-article","created":{"date-parts":[[2008,4,11]],"date-time":"2008-04-11T15:58:49Z","timestamp":1207929529000},"page":"935-938","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":12,"title":["Mifepristone for ectopic ACTH secretion in metastatic endocrine carcinomas: report of two cases."],"prefix":"10.1093","volume":"158","author":[{"given":"Philippe A","family":"Cassier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawsan","family":"Abou-Amara-Olivieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Artru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-George","family":"Lapalus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Riou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Lombard-Bohas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"8","key":"1_19316672","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.1210\/jc.2004-2527","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"2_21116271","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1210\/jc.2005-1542","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"10","key":"3_4999163","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM198809083191003","volume":"319","author":"Wynick","year":"1988","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"5","key":"4_29813032","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1530\/EJE-07-0458","volume":"157","author":"Johanssen","year":"2007","journal-title":"European Journal of Endocrinology","ISSN":"http:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"6","key":"5_10289573","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1056\/NEJM199308053290607","volume":"329","author":"Spitz","year":"1993","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"11","key":"6_17312552","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1038\/nm784","volume":"8","author":"Heaney","year":"2002","journal-title":"Nature medicine","ISSN":"http:\/\/id.crossref.org\/issn\/1078-8956","issn-type":"print"},{"issue":"1","key":"7_13839557","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM198607033150101","volume":"315","author":"Maton","year":"1986","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"6","key":"8_4942462","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1136\/gut.29.6.838","volume":"29","author":"Ruszniewski","year":"1988","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"issue":"1","key":"9_22776747","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1210\/jc.2006-0728","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"10_31121087","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0163-7258(96)00016-2","volume":"70","year":"1996","journal-title":"PHARMACOLOGY AND THERAPEUTICS"},{"issue":"3","key":"11_13566896","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1210\/jcem-61-3-536","volume":"61","author":"NIEMAN","year":"1985","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"http:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/158\/6\/935.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/158\/6\/935.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:22Z","timestamp":1676391682000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/158\/6\/935\/6676041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":11,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-07-0792","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}