{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T17:11:16Z","timestamp":1724519476378},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Osteoprotegerin (OPG), an inhibitor of osteoclastic bone resorption, has a variety of functions including anti-inflammatory effects and a possible cardiovascular protective role. Both low-grade chronic inflammation and cardiovascular risk are increased in women with the polycystic ovary syndrome (PCOS). We aimed to study serum OPG concentrations in PCOS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study including 40 PCOS patients matched with 40 non-hyperandrogenic women for age and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Basal serum sampling and standard oral glucose tolerance test, and measurement of serum OPG concentrations by commercial ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum OPG concentrations were lower in women with PCOS compared with those of controls (304\u00b1120 vs 363\u00b1105\u200apg\/ml respectively; <jats:italic>F<\/jats:italic>=7.641, <jats:italic>P<\/jats:italic>=0.007) independently of obesity. No differences were observed in serum receptor activator of nuclear factor-\u03baB ligand (RANKL) levels and in the RANKL\/OPG molar ratio. A multivariate linear regression model (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>=0.208, <jats:italic>F<\/jats:italic>=6.579, <jats:italic>P<\/jats:italic>=0.001) showed that PCOS (<jats:italic>\u03b2<\/jats:italic>=\u22120.281, <jats:italic>P<\/jats:italic>=0.008), obesity (<jats:italic>\u03b2<\/jats:italic>=\u22120.245, <jats:italic>P<\/jats:italic>=0.022) and age (<jats:italic>\u03b2<\/jats:italic>=0.296, <jats:italic>P<\/jats:italic>=0.006) were predictive of serum OPG concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum OPG concentrations are reduced in PCOS patients independently of obesity. Considering the anti-inflammatory effects of OPG, its reduced serum concentrations might contribute to the proinflammatory state and cardiovascular risk of PCOS patients.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-08-0107","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T00:25:45Z","timestamp":1214439945000},"page":"225-232","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":13,"title":["Serum osteoprotegerin concentrations are decreased in women with the polycystic ovary syndrome"],"prefix":"10.1093","volume":"159","author":[{"given":"H\u00e9ctor F","family":"Escobar-Morreale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 I","family":"Botella-Carretero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma \u00c1ngeles","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Luque-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"\u00c1lvarez-Blasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L San","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/159\/3\/225.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/159\/3\/225.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:43Z","timestamp":1676391703000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/159\/3\/225\/6675940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-08-0107","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}