{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:44:25Z","timestamp":1789447465808,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Hypothyroidism is a manifestation of multi-hormonal resistance in pseudohypoparathyroidism type Ia (PHP Ia). The objective of the study was to determine the mechanisms of hypothyroidism in PHP Ia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Ten patients with PHP Ia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The serum concentrations of TSH, free triiodothyronine (FT<jats:sub>3<\/jats:sub>), free thyroxine (FT<jats:sub>4<\/jats:sub>), and prolactin (PRL) were measured at baseline and after stimulation with TRH (200\u200a\u03bcg i.v).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median basal serum TSH concentration was 4.92\u200amU\/l. Basal serum TSH concentration was slightly elevated in eight patients (4.22\u20137.0\u200amU\/l; normal range, 0.4\u20133.6\u200amU\/l), normal in one patient (2.5\u200amU\/l), and high in one patient (13.1\u200amU\/l). After the TRH test, TSH concentrations increased to 13.4\u201336.0\u200amU\/l (normal range, 4.0\u201320.0\u200amU\/l). The absolute values after the test were normal in three patients and high in seven patients. However, TSH responses relative to the baseline value (stimulated\/basal TSH and expressed as a fold increase), which reflect the relative increases after TRH stimulation, were low in seven patients (2.3- to 4.3-fold TSH) and normal in three patients. Basal FT<jats:sub>4<\/jats:sub> concentration was normal in seven patients and low in three patients (range, 8.4\u201320.0\u200apmol\/l; mean, 14.1\u00b14.3\u200apmol\/l; normal range, 10.5\u201323.0\u200apmol\/l). Basal FT<jats:sub>3<\/jats:sub> concentration was normal in nine patients and low in one patient (range, 0.9\u20135.0\u200apmol\/l; mean, 3.8\u00b11.1\u200apmol\/l; normal range, 3.3\u20136.1\u200apmol\/l). FT<jats:sub>4<\/jats:sub> and FT<jats:sub>3<\/jats:sub> were not significantly increased after the TRH test. PRL concentration was normal at baseline and increased from 7 to 96\u200ang\/ml after TRH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results support the hypothesis that patients with PHP Ia have impaired sensitivity to both TSH and TRH.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-08-0111","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T17:02:55Z","timestamp":1221843775000},"page":"431-437","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":29,"title":["Hypothyroidism in patients with pseudohypoparathyroidism type Ia: clinical evidence of resistance to TSH and TRH"],"prefix":"10.1093","volume":"159","author":[{"given":"Anne-Sophie","family":"Balavoine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Ladsous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz-Line","family":"Velayoudom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Vlaeminck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cardot-Bauters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"d'Herbomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Wemeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/159\/4\/431.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/159\/4\/431.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:44Z","timestamp":1676391704000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/159\/4\/431\/6675993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-08-0111","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}