{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:03:27Z","timestamp":1792249407144,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Increased reverse tritiodothyronine (T<jats:sub>3<\/jats:sub>) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T<jats:sub>3<\/jats:sub> in non-severely ill subjects but its significance remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and design<\/jats:title><jats:p>The Alsanut study included a representative sample of 440 independently-living subjects aged 65 or over constituted between January 1988 and September 1989. Past and current medical history and nutritional data were collected at inclusion. Baseline thyroid hormone (TSH, FT<jats:sub>4<\/jats:sub>, FT<jats:sub>3<\/jats:sub> and rT<jats:sub>3<\/jats:sub>) serum levels were measured. Life status was determined on 1 December 2005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 374 elderly subjects included in the final analysis, 52 had abnormal TSH (43 with hyperthyroidism, nine with hypothyroidism) and 80.7% had died by 1 December 2005. There was no statistical difference in survival between subjects according to thyroid function (<jats:italic>P<\/jats:italic>=0.54). Of the 322 elderly subjects with normal TSH, mortality rate was 81.1%. ESS was found in 3.4%, whereas 8.1% of the participants displayed elevated rT<jats:sub>3<\/jats:sub> with normal FT<jats:sub>3<\/jats:sub>. Time to death was strongly related to rT<jats:sub>3<\/jats:sub> (<jats:italic>P<\/jats:italic>&lt;0.0001) and FT<jats:sub>3<\/jats:sub> (<jats:italic>P<\/jats:italic>&lt;0.0001) in a univariate analysis. After adjusting for other confounding variables, rT<jats:sub>3<\/jats:sub> was the only thyroid hormone associated with shorter survival (<jats:italic>P<\/jats:italic>=0.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RT<jats:sub>3<\/jats:sub> was the only thyroid hormone associated with shorter survival in a representative population of independently-living elderly. In these subjects, isolated elevated rT<jats:sub>3<\/jats:sub> might be an equivalent of ESS, reflecting declining health.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-08-0519","type":"journal-article","created":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T01:45:41Z","timestamp":1226367941000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":17,"title":["Increased reverse triiodothyronine is associated with shorter survival in independently-living elderly: the Alsanut study"],"prefix":"10.1093","volume":"160","author":[{"given":"E","family":"Forestier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Vinzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Schlienger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Goichot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/160\/2\/207.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/160\/2\/207.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:22:24Z","timestamp":1676391744000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/160\/2\/207\/6676160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-08-0519","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}