{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:44:33Z","timestamp":1778049873493,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>A 64-year-old woman was previously treated for Cushing's disease with trans-sphenoidal surgery, external beam radiotherapy and bilateral adrenalectomy. Progression of an aggressive corticotroph adenoma was evident 3 years post-adrenalectomy; involvement of the clivus was treated with surgery and gamma knife radiosurgery. Tumour spread through the skull base, occiput and left ear with persistent facial pain and left ear discharge; progression continued despite second gamma knife treatment. ACTH levels peaked at 2472 and 2265\u200apmol\/l pre- and post-hydrocortisone respectively. Treatment with temozolomide resulted in a significant improvement in symptoms, a reduction of plasma ACTH to 389\u200apmol\/l and regression of tumour on magnetic resonance imaging scan after four cycles of treatment. We propose that temozolomide is an effective and well-tolerated therapeutic tool for the treatment of Nelson's syndrome and a useful addition to the range of therapies available to treat this condition.<\/jats:p>","DOI":"10.1530\/eje-08-0557","type":"journal-article","created":{"date-parts":[[2008,11,5]],"date-time":"2008-11-05T02:16:43Z","timestamp":1225851403000},"page":"115-119","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":59,"title":["Treatment of Nelson's syndrome with temozolomide"],"prefix":"10.1093","volume":"160","author":[{"given":"V J","family":"Moyes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Alusi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H I","family":"Sabin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Evanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Berney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Monson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P N","family":"Plowman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Drake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"1","key":"1_28303034","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11102-007-0014-1","volume":"10","author":"Neff","year":"2007","journal-title":"Pituitary","ISSN":"https:\/\/id.crossref.org\/issn\/1386-341X","issn-type":"print"},{"issue":"1","key":"2_23129843","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.humpath.2006.07.014","volume":"38","author":"Kovacs","year":"2007","journal-title":"Human pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0046-8177","issn-type":"print"},{"issue":"6","key":"3_22241277","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/S1470-2045(06)70728-8","volume":"7","author":"Lim","year":"2006","journal-title":"The lancet oncology","ISSN":"https:\/\/id.crossref.org\/issn\/1470-2045","issn-type":"print"},{"issue":"4","key":"4_22827965","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3171\/jns.2006.105.4.621","volume":"105","author":"Fadul","year":"2006","journal-title":"Journal of neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3085","issn-type":"print"},{"issue":"2","key":"5_30913898","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00401-007-0279-5","volume":"115","author":"Kovacs","year":"2008","journal-title":"Acta neuropathologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6322","issn-type":"print"},{"issue":"4","key":"6_3507773","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJM195807242590403","volume":"259","author":"Nelson","year":"1958","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"4","key":"7_21457862","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s11102-005-1403-y","volume":"7","author":"Assi\u00a0\u00a0","year":"2004","journal-title":"Pituitary","ISSN":"https:\/\/id.crossref.org\/issn\/1386-341X","issn-type":"print"},{"issue":"1","key":"8_22874444","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1210\/jc.2006-1328","volume":"92","year":"2007","journal-title":"Journal of Clinical Endocrinology &amp; 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