{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:51:42Z","timestamp":1773150702147,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although, adiponectin might be associated with bone metabolism, the relationships between serum adiponectin and bone mineral density (BMD) as well as vertebral fracture in type 2 diabetes are still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective and methods<\/jats:title><jats:p>We investigated the relationships between each of serum total and high molecular weight (HMW) adiponectin versus BMD, bone markers, and the presence of vertebral fractures in a total of 231 men and 170 post-menopausal women with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple regression analysis adjusted for age, duration of diabetes, BMI, serum creatinine, and HbA<jats:sub>1c<\/jats:sub> showed that serum total adiponectin was negatively correlated with BMD at the total, lumbar spine, and femoral neck (<jats:italic>r<\/jats:italic>=\u22120.165, <jats:italic>P<\/jats:italic>&lt;0.05; <jats:italic>r<\/jats:italic>=\u22120.187, <jats:italic>P<\/jats:italic>&lt;0.05; and <jats:italic>r<\/jats:italic>=\u22120.136, <jats:italic>P<\/jats:italic>&lt;0.05 respectively) and positively with urinary N-terminal cross-linked telopeptide of type-I collagen in men (<jats:italic>r<\/jats:italic>=0.148, <jats:italic>P<\/jats:italic>&lt;0.05), and that serum HMW adiponectin was negatively correlated with BMD at the lumbar spine (<jats:italic>r<\/jats:italic>=\u22120.146, <jats:italic>P<\/jats:italic>&lt;0.05). Multivariate logistic regression analysis adjusted for the parameters described above showed that total adiponectin was associated with the presence of vertebral fractures in men (odds ratio (OR)=1.396, 95% confidential interval (CI) 1.020\u20131.911 per <jats:sc>s.d.<\/jats:sc> increase, <jats:italic>P<\/jats:italic>&lt;0.05), and both total and HMW adiponectin were associated with moderate or severe vertebral fractures (OR=1.709, 95% CI 1.048\u20132.787 per <jats:sc>s.d.<\/jats:sc> increase, <jats:italic>P<\/jats:italic>&lt;0.05 and OR=1.810, 95% CI 1.112\u20132.946 per <jats:sc>s.d.<\/jats:sc> increase, <jats:italic>P<\/jats:italic>&lt;0.05 respectively), but not in post-menopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum adiponectin could be associated with BMD and turnover and clinically useful for assessing the risk of vertebral fractures in type 2 diabetic men.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-08-0642","type":"journal-article","created":{"date-parts":[[2008,11,8]],"date-time":"2008-11-08T01:54:12Z","timestamp":1226109252000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":81,"title":["Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellitus"],"prefix":"10.1093","volume":"160","author":[{"given":"Ippei","family":"Kanazawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitsugu","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/160\/2\/265.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/160\/2\/265.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:22:37Z","timestamp":1676391757000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/160\/2\/265\/6676218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-08-0642","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}