{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:17:14Z","timestamp":1789525034767,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The investigation of expression and functional relevance of G-protein coupled receptors in primary aldosteronism (PA) by molecular and clinical studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      Tissues of 14 aldosterone-producing adenomas (APA), of one unilateral adrenal hyperplasia and of six healthy adult adrenal glands; 12 patients with confirmed PA due to APA; (\n                      <jats:italic>n<\/jats:italic>\n                      =5), idiopathic hyperaldosteronism (\n                      <jats:italic>n<\/jats:italic>\n                      =7) and 8 control subjects (C). The tissues were subjected to a quantitative PCR for determination of mRNA expression levels of AT2R1, GIPR, MC2R, GnRHR, LHR, TRHR, TSHR, glucagon-R, V1aR, V2R, and 5-HT4R. The patients and controls were enrolled in a test protocol consisting of stimulation by posture, mixed meal, ACTH, GnRH, TRH, glucagon, vasopressin, and metoclopramide (MCP). Three patients could be analyzed by both studies. A positive response was defined as an aldosterone increase of more than 50% following stimulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All the tissues revealed AT2R1, MC2R, AVPR, and 5-HT4R mRNA expression. LHR mRNA was found in normal adrenals and 13 adrenal tumors. By contrast with normal adrenals tumorous adrenal tissue expressed GnRHR mRNA (4\/15) and TSHR mRNA (1\/15). Both the patients and controls responded to posture, ACTH, glucagon, AVP, and MCP. Specific responses were seen in one patient following TRH and three patients following GnRH stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We provide evidence for peptide hormone responsiveness to various peptide hormones in patients with PA, including GnRH and TRH. A good correlation between clinical and molecular testing could be observed, making an involvement of the receptor expressed in PA possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-08-0711","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T21:09:59Z","timestamp":1231448999000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":70,"title":["Screening for membrane hormone receptor expression in primary aldosteronism"],"prefix":"10.1093","volume":"160","author":[{"given":"O","family":"Zwermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Suttmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bidlingmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Beuschlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Reincke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"3","key":"1_18072083","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1210\/jc.2003-031337","volume":"89","author":"Mulatero","year":"2004","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"11","key":"2_22950147","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","volume":"48","year":"2006","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"4","key":"3_3228850","first-page":"661","volume":"45","author":"Conn","year":"1955","journal-title":"The Journal of laboratory and clinical medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2143","issn-type":"print"},{"issue":"14","key":"4_9956800","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM199210013271403","volume":"327","author":"Reznik","year":"1992","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"14","key":"5_9956799","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1056\/NEJM199210013271402","volume":"327","author":"Lacroix","year":"1992","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"1","key":"6_11029098","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1210\/er.22.1.75","volume":"22","author":"Lacroix","year":"2001","journal-title":"Endocrine Reviews","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"issue":"10","key":"7_10534361","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.1210\/jc.85.10.3531","volume":"85","author":"Mircescu","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"8_18745071","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1210\/jc.2004-1256","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"9_18429694","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1365-2265.2004.02048.x","volume":"61","author":"Reznik","year":"2004","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"3","key":"10_19478222","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000088818","volume":"64","author":"Christopoulos","year":"2005","journal-title":"Hormone research","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"21","key":"11_6353089","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1056\/NEJM199911183412104","volume":"341","author":"Lacroix","year":"1999","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"11","key":"12_11394276","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1210\/jc.86.11.5534","volume":"86","author":"Bourdeau","year":"2001","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"13_17466205","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1210\/jc.2002-020621","volume":"88","author":"Feelders","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"20","key":"14_5778536","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1056\/NEJM199711133372004","volume":"337","author":"Lacroix","year":"1997","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"1","key":"15_6049562","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1056\/NEJM199807023390105","volume":"339","author":"Willenberg","year":"1998","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"1","key":"16_11333109","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1385\/ENDO:15:1:057","volume":"15","author":"Nakamura","year":"2001","ISSN":"https:\/\/id.crossref.org\/issn\/1355-008X","issn-type":"print"},{"issue":"6","key":"17_6040272","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1210\/jc.83.6.2029","volume":"83","author":"Arnaldi","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"18_6271811","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1046\/j.1365-2265.1998.00490.x","volume":"49","author":"Daidoh","year":"1998","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"19_30142029","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1677\/JOE-07-0413","volume":"196","author":"Louiset","year":"2008","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"1","key":"20_17466208","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1210\/jc.2002-021107","volume":"88","author":"Cartier","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"10","key":"21_17856285","doi-asserted-by":"publisher","first-page":"4616","DOI":"10.1210\/jc.2002-021949","volume":"88","author":"Mannelli","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"22_21135088","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1210\/jc.2005-1298","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"23_29519069","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1677\/JOE-07-0037","volume":"195","author":"Ye","year":"2007","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"4","key":"24_21539757","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1210\/jc.2005-1453","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6","key":"25_19731018","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1530\/eje.1.02051","volume":"153","author":"Cartier","year":"2005","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"3-4","key":"26_6292139","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3109\/07435809809032681","volume":"24","author":"Lefebvre","year":"1998","journal-title":"Endocrine research","ISSN":"https:\/\/id.crossref.org\/issn\/0743-5800","issn-type":"print"},{"issue":"3","key":"27_16953483","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1210\/jc.87.3.1211","volume":"87","author":"Lefebvre","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"28_5996469","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1677\/joe.0.1560415","volume":"156","author":"Reincke","year":"1998","journal-title":"Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"5","key":"29_11172326","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1046\/j.1365-2265.2001.01253.x","volume":"54","author":"Schubert","year":"2001","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"1","key":"30_9885662","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1210\/jc.75.1.323","volume":"75","author":"Nomura","year":"1992","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"31_8990101","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1210\/jcem-57-2-388","volume":"57","author":"GANGULY","year":"1983","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6-7","key":"32_6105834","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1055\/s-2007-978904","volume":"30","author":"Lefebvre","year":"1998","journal-title":"Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et m&#x00A0;&#x00A0;tabolisme","ISSN":"https:\/\/id.crossref.org\/issn\/0018-5043","issn-type":"print"},{"issue":"6","key":"33_10246784","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1210\/jc.76.6.1522","volume":"76","author":"Perraudin","year":"1993","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"34_15779730","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1210\/en.136.3.1285","volume":"136","author":"Guillon","year":"1995","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"12","key":"35_17360632","doi-asserted-by":"publisher","first-page":"5706","DOI":"10.1210\/jc.2002-020067","volume":"87","author":"Mune","year":"2002","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"36_32167366","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1530\/acta.0.0750125","volume":"75","author":"Coslovsky","year":"1974","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"6-7","key":"37_6105829","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-2007-978899","volume":"30","author":"Gallo-Payet","year":"1998","journal-title":"Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et m&#x00A0;&#x00A0;tabolisme","ISSN":"https:\/\/id.crossref.org\/issn\/0018-5043","issn-type":"print"},{"issue":"6","key":"38_11778854","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1172\/JCI106608","volume":"50","author":"Schorr","year":"1971","journal-title":"Journal of Clinical Investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"issue":"10","key":"39_8247261","first-page":"3768","volume":"40","author":"Matsukura","year":"1980","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"6","key":"40_5879682","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1089\/thy.1997.7.879","volume":"7","author":"Dutton","year":"1997","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/160\/3\/443.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/160\/3\/443.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:22:43Z","timestamp":1676373763000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/160\/3\/443\/6676356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":40,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/eje-08-0711","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1159377.619730","asserted-by":"object"}]},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}