{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:19:57Z","timestamp":1772792397694,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse 12-month response to GH treatment in a single-country cohort of hypopituitary adult patients with GH deficiency (GHD) in regards to health-related quality of life (HRQoL) and insulin-like growth factor-1 (IGF-1) compared with values from general population sample. Moreover, association between the response in HRQoL and the IGF-1 values in patients and in the background population was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>HRQoL was assessed by quality of life assessment of GH deficiency in adults (QoL-AGHDA) in 651 patients retrieved from the German KIMS (Pfizer International Metabolic Database) before and after 12 months of GH replacement and in a sample drawn from a cross-sectional study in Germany (<jats:italic>n<\/jats:italic>=2734). IGF-1 was measured in KIMS patients and in the population-based study with the same assay technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In KIMS patients, mean QoL-AGHDA scores before GH replacement were 9.2\u00b16.8 (8.7\u00b16.8) in women (men) and in the general population sample 4.5\u00b15.3 (4.3\u00b15.0) in women (men). Mean differences in QoL-AGHDA scores were statistically significant for all age categories (<jats:italic>P<\/jats:italic>&lt;0.05). The mean IGF-1 SDS of KIMS patients before GH replacement was \u22121.1\u00b11.4 (\u22120.8\u00b11.4) in women (men). After GH replacement, a significant increase of IGF-1 concentration and a significant decrease of QoL-AGHDA scores near to age- and gender-specific population-based values were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms an improvement in HRQoL and an increase of IGF-1 SDS in GH-replaced adults, which approximated the values of general population. However, there was no association between IGF-1 values and HRQoL assessment as one of the important treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-08-0738","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T00:54:40Z","timestamp":1225414480000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":28,"title":["Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the Study of Health in Pomerania"],"prefix":"10.1093","volume":"160","author":[{"given":"Joern","family":"Moock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christin","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Koltowska-Haggstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kohlmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Wallaschofski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"2","key":"1_5888242","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1210\/jc.83.2.382","volume":"83","author":"Carroll","year":"1998","journal-title":"Journal of Clinical Endocrinology &amp; 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