{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:42:50Z","timestamp":1768815770643,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Glucagon-like peptide 1 (GLP-1) is an incretin hormone that stimulates glucose-induced insulin secretion, increases \u03b2-cell proliferation, neogenesis and \u03b2-cell mass. In adults, plasma concentrations of amidated GLP-1 are typically within the 5\u201310\u200apmol\/l range in the fasting state and increases to \u223c50\u200apmol\/l after ingestion of a mixed meal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research design and methods<\/jats:title><jats:p>We measured plasma glucose, insulin and amidated forms of GLP-1 prefeed and then at 20 and 60\u200amin post-feed following ingestion of a 60\u201370\u200aml of standard milk feed in preterm (<jats:italic>n<\/jats:italic>=10, 34\u201337 weeks) and term newborn infants (<jats:italic>n<\/jats:italic>=12, 37\u201342 weeks). Reverse-phase fast protein liquid chromatography was used to characterise the molecular nature of the circulating GLP-1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean birth weight was 3.18\u200akg and mean age at sampling for GLP-1 was 7.7 days. The mean basal GLP-1 concentration was 79.1\u200apmol\/l, which increased to 156.6\u200apmol\/l (\u00b170.9,<jats:italic>P<\/jats:italic>&lt;0.001) and 121.5\u200apmol\/l (\u00b159.2) at 20\u200aand 60\u200amin respectively. Reverse-phase chromatography analysis suggested that the majority of GLP-1 immunoreactivity (&gt;75%) represented GLP-1 (7\u201336) amide and (9\u201336) amide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Basal and post-feed amidated GLP-1 concentrations in neonates are grossly raised with the major fractions of circulating GLP-1 being (7\u201336) amide and (9\u201336) amide. Elevated GLP-1 concentrations in the newborn period may have a role in regulating maturation of enteroendocrine system and also of increasing pancreatic \u03b2-cell mass and regeneration. The high levels of GLP-1 may be due to immaturity of the dipeptidyl peptidase IV and or lower glomerular filtration rate in the neonatal period. Further studies are required to understand the role of GLP-1 in the neonatal period.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-08-0807","type":"journal-article","created":{"date-parts":[[2008,10,25]],"date-time":"2008-10-25T00:45:36Z","timestamp":1224895536000},"page":"53-58","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":32,"title":["Elevated basal and post-feed glucagon-like peptide 1 (GLP-1) concentrations in the neonatal period"],"prefix":"10.1093","volume":"160","author":[{"given":"Raja","family":"Padidela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawfal","family":"Sharief","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Ghatei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"4","key":"1_9930012","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/j.1365-2362.1992.tb01464.x","volume":"22","author":"Eissele","year":"1992","journal-title":"European journal of clinical investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2972","issn-type":"print"},{"issue":"11","key":"2_14393038","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/BF00274797","volume":"30","author":"Orskov","year":"1987","journal-title":"Diabetologia","ISSN":"https:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"issue":"14","key":"3_5629714","doi-asserted-by":"crossref","first-page":"8001","DOI":"10.1016\/S0021-9258(19)39030-1","volume":"265","author":"Mojsov","year":"1990","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"4_14699130","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2337\/diab.43.4.535","volume":"43","author":"Orskov","year":"1994","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"8","key":"5_15959157","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1210\/en.136.8.3585","volume":"136","author":"Kieffer","year":"1995","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"3","key":"6_11066155","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2337\/diabetes.50.3.609","volume":"50","author":"Vilsboll","year":"2001","journal-title":"Diabetes","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"issue":"6","key":"7_21615234","doi-asserted-by":"publisher","first-page":"E1144","DOI":"10.1152\/ajpendo.00571.2005","volume":"291","year":"2006","journal-title":"American Journal of Physiology - 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