{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:22:03Z","timestamp":1772580123224,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:sec><jats:title>Context<\/jats:title><jats:p>A discrepancy between serum GH and IGF1 concentrations is frequent in patients with acromegaly. Here, we examined whether the exon 3-deleted (d3) GH receptor (<jats:italic>GHR<\/jats:italic>) variant, which has been linked to increased responsiveness to GH treatment in short children, influences the GH\/IGF1 relationship in patients with acromegaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the possible influence of the <jats:italic>GHR<\/jats:italic> genotype on the GH\/IGF1 relationship in untreated acromegalic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p><jats:italic>GHR<\/jats:italic> genotype analysis with retrospective clinical and biochemical data collection performed in a single third-reference medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Clinical data were obtained from the medical records of 105 acromegalic patients who had GH and IGF1 assays in the same laboratory and who were genotyped for the full-length (fl) or d3-<jats:italic>GHR<\/jats:italic> alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The distribution of <jats:italic>GHR<\/jats:italic> genotypes was 51% fl\/fl, 30% fl\/d3, and 19% d3\/d3. Patients with d3\/d3 genotype were younger than the patients in the other two groups (<jats:italic>P<\/jats:italic>&lt;0.05). Baseline GH and IGF1 concentrations did not differ among the three groups. The linear correlation between GH and IGF1 concentrations was similar in the three genotypic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The exon 3 <jats:italic>GHR<\/jats:italic> genotype does not affect the GH\/IGF1 relationship in untreated acromegalic patients with high circulating GH and IGF1 levels.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-09-0053","type":"journal-article","created":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T00:35:05Z","timestamp":1242261305000},"page":"231-235","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":26,"title":["D3 GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly"],"prefix":"10.1093","volume":"161","author":[{"given":"Peter","family":"Kamenicky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Salenave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Galland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Le Bouc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Maison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bougn\u00e8res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/161\/2\/231.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/161\/2\/231.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:12Z","timestamp":1676391792000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/161\/2\/231\/6676183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-09-0053","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}