{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:23:54Z","timestamp":1783484634151,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze, at a population level, the relation between the incidences of benign thyroid diseases in patients submitted to surgery and that of thyroid cancers based on their respective geographical distributions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 3169 cases (691 cancers and 2478 benign diseases) operated on in 2002 in the Rh\u00f4ne-Alpes <jats:italic>r\u00e9gion<\/jats:italic>, which is subdivided into eight <jats:italic>d\u00e9partements<\/jats:italic> and 311 <jats:italic>cantons<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total thyroid intervention rate was 54.6\/100\u200a000 (23.4 and 86.4), and the annual cancer incidence was 11.9\/100\u200a000 (4.7 and 13.8) for men and women respectively. The prevalence of cancer among thyroid surgery was 21.8% and that of cancer discovered in goiters increased with age (44% at 60 years). Intervention rates varied from <jats:italic>d\u00e9partment<\/jats:italic> to <jats:italic>d\u00e9partement<\/jats:italic>. In women, the incidence of microcancers was correlated to the thyroid intervention for benign pathologies rate. In men, the incidence of supracentimetric cancers was related to the TIBR. At the canton level, the relative risk of benign diseases was correlated to that of cancers. TIBR and incidence of cancers were higher in urban <jats:italic>cantons<\/jats:italic> than in nonurban ones. The density of endocrinologists influenced the prevalence of cancers among all the cases submitted to surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the Rh\u00f4ne-Alpes population with high rates of thyroid cancer incidence and of thyroid surgery, a number of correlations were found according to gender and tumor size. However, the general incidence of cancer was not directly related to surgical activity. Geographical variability may be related to the heterogeneous medical and pathological practices.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-09-0570","type":"journal-article","created":{"date-parts":[[2009,9,30]],"date-time":"2009-09-30T01:47:17Z","timestamp":1254275237000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["Geographical correlation between incidence of benign disease and that of cancer of the thyroid among the population of the Rh\u00f4ne-Alpes r\u00e9gion of France"],"prefix":"10.1093","volume":"162","author":[{"given":"Genevi\u00e8ve","family":"Sassolas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakia","family":"Hafdi-Nejjari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Schott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bournaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Louis","family":"Peix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Orgiazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Dutrieux-Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Borson-Chazot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"2_36172464","first-page":"297","volume":"3","year":"1928","journal-title":"CANCER REVIEW"},{"key":"3_36172465","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0277-5379(91)90069-P","volume":"27","year":"1991","journal-title":"European journal of cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2964","issn-type":"print"},{"issue":"4","key":"4_10956619","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1093\/ije\/28.4.626","volume":"28","author":"Fioretti","year":"1999","journal-title":"International Journal of Epidemiology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-5771","issn-type":"print"},{"issue":"3","key":"5_14280745","first-page":"301","volume":"171","author":"Mornex","year":"1987","journal-title":"Bulletin de l'Academie Nationale de Medecine","ISSN":"https:\/\/id.crossref.org\/issn\/0001-4079","issn-type":"print"},{"issue":"1","key":"6_32341539","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1530\/EJE-08-0624","volume":"160","year":"2009","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"2","key":"7_18030758","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1530\/eje.0.1500133","volume":"150","author":"Leenhardt","year":"2004","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"5","key":"8_23090192","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0398-7620(06)76737-2","volume":"54","author":"Hafdi-Nejjari","year":"2006","journal-title":"Revue d'&#x00A0;&#x00A0;pid&#x00A0;&#x00A0;miologie et de sant&#x00A0;&#x00A0; 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