{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T11:50:27Z","timestamp":1719143427132},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the levels of adiponectin and its subforms before and immediately after delivery to estimate the effect of cessating advanced pregnancy on circulating adiponectin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>In a cohort of 37 women with uncomplicated singleton pregnancies and 6 women with twin pregnancies, serum adiponectin was measured before caesarean section (CS) in the fasting state, and 24 and 48\u200ah after CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum adiponectin levels declined within 24\u200ah of delivery from median 8.34\u200amg\/l (range 5.57\u201320.47) to 6.81\u200amg\/l (4.16\u201317.39) after 24\u200ah and 6.84\u200amg\/l (3.83\u201317.42) after 48\u200ah. This corresponded to a relative decrease to 83\u00b16 and 81\u00b17% of pregnant values after 24 and 48\u200ah respectively (<jats:italic>P<\/jats:italic>&lt;0.001, ANOVA). In twin pregnancies, maternal adiponectin levels displayed a decrease that was the same as that displayed by them after birth (<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><jats:p>High-molecular weight adiponectin constituted 50\u00b18% (range 34\u201368%) of total adiponectin. Absolute changes in adiponectin levels after delivery were most pronounced in this subfraction. The percentage medium-molecular weight adiponectin decreased slightly, but significantly (from 37\u00b16 to 35\u00b15%,<jats:italic>P<\/jats:italic>&lt;0.001), and a similar statistically significant rise was observed in the low-molecular weight fraction (from 13\u00b12 to 15\u00b13%;<jats:italic>P<\/jats:italic>&lt;0.001) within 48\u200ah of delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Decreases in adiponectin levels occur shortly after delivery, and adiponectin subforms initiate the changes towards the non-pregnant state.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-10-0017","type":"journal-article","created":{"date-parts":[[2010,4,10]],"date-time":"2010-04-10T00:58:59Z","timestamp":1270861139000},"page":"69-73","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["Alterations in circulating adiponectin levels occur rapidly after parturition"],"prefix":"10.1093","volume":"163","author":[{"given":"Jens","family":"Fuglsang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puk","family":"Sandager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Flyvbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Ovesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"1","key":"1_17970983","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2337\/diacare.27.1.274","volume":"27","author":"Cseh","year":"2004","journal-title":"Diabetes Care","ISSN":"http:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"key":"2_35572034","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00125-006-0264-x","volume":"49","year":"2006","ISSN":"http:\/\/id.crossref.org\/issn\/1432-0428","issn-type":"print"},{"issue":"11","key":"3_10561976","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1210\/jc.85.11.4298","volume":"85","author":"Linnemann","year":"2000","journal-title":"Journal of Clinical Endocrinology &amp; 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