{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:37:26Z","timestamp":1791218246932,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Screening of thyroid disorders in pregnancy has been controversial. Recent recommendations favour targeted high-risk case finding, though this approach may miss a significant number of those affected. We aimed to assess the prevalence of accepted high-risk criteria in women with autoimmune thyroiditis and\/or hypothyroidism detected from universal screening in an iodine-sufficient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>In 400 non-selected women in the 9\u201311th gestational week, thyroid-related tests were performed, and those with abnormalities were offered consultation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      TSH was determined by IRMA, and the upper cut-off value for screening was set at 3.5\u200amIU\/l. For free thyroxine (FT\n                      <jats:sub>4<\/jats:sub>\n                      ) and thyroperoxidase antibodies (TPO-Ab), RIAs were used, with cut-offs of &lt;10\u200apmol\/l and &gt;50\u200aIU\/ml respectively. Endocrinological consultation included Doppler ultrasonography and was aimed to confirm autoimmune thyroiditis and\/or hypothyroidism. The prevalence of consensus high-risk criteria was assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 400 women, 65 (16.3%) had \u22651 abnormality: higher TSH was found in 10.3%, lower FT\n                      <jats:sub>4<\/jats:sub>\n                      in 2% and positive TPO-Ab in 8.3%. Fifty-one women were examined and followed up. Levo-T\n                      <jats:sub>4<\/jats:sub>\n                      treatment was initiated in 49 women for autoimmune thyroiditis (in 42), hypothyroidism (in 34) or both (in 27). Only 22 (45%) of 49 treated women fulfilled \u22651 high-risk criterion: most commonly family history (31%), history of miscarriage or preterm delivery (14%) and personal history (8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over half (55%) of pregnant women with abnormalities suggestive of autoimmune thyroiditis and\/or hypothyroidism would be missed if only those with high-risk criteria were examined. A more extensive screening of thyroid autoimmunity and dysfunction seems warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-10-0516","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T21:11:28Z","timestamp":1280869888000},"page":"645-650","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":90,"title":["Universal screening detects two-times more thyroid disorders in early pregnancy than targeted high-risk case finding"],"prefix":"10.1093","volume":"163","author":[{"given":"Jiri","family":"Horacek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Spitalnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanka","family":"Dlabalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Malirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Vizda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Svilias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Cepkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Mc Grath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Maly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1_29459525","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.beem.2004.03.007","volume":"18","year":"2004","journal-title":"BEST PRACTICE AND RESEARCH CLINICAL ENDOCRINOLOGY AND METABOLISM"},{"issue":"7","key":"2_21945164","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1210\/jc.2005-1603","volume":"91","year":"2006","journal-title":"Journal of Clinical Endocrinology &amp; 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