{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:36:05Z","timestamp":1791218165658,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>studies in animal models have shown that parathyroid hormone (PTH) inhibits the expression of the<jats:italic>SOST<\/jats:italic>gene, which encodes sclerostin, an osteocyte-derived negative regulator of bone formation. We tested the hypothesis that chronic PTH excess decreases circulating sclerostin in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We studied 25 patients with elevated serum PTH concentrations due to primary hyperparathyroidism (PHPT) and 49 patients cured from PHPT after successful parathyroidectomy (PTx; euparathyroid controls (EuPTH)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured plasma PTH and serum sclerostin levels and the serum markers of bone turnover alkaline phosphatase, P1NP, and \u03b2-CTX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As expected by the design of the study, mean plasma PTH was significantly higher (<jats:italic>P<\/jats:italic>&lt;0.001) in PHPT patients (15.3\u200apmol\/l; 95% confidence interval (CI): 11.1\u201319.5) compared with that of EuPTH controls (4.1\u200apmol\/l; 95% CI: 3.6\u20134.5). PHPT patients had significantly lower serum sclerostin values compared with those in EuPTH subjects (30.5\u200apg\/ml; 95% CI: 26.0\u201335.1 vs 45.4\u200apg\/ml; 95% CI: 40.5\u201350.2;<jats:italic>P<\/jats:italic>&lt;0.001) and healthy controls (40.0\u200apg\/ml; 95% CI: 37.1\u201342.9;<jats:italic>P<\/jats:italic>=0.01). Plasma PTH concentrations were negatively correlated with serum sclerostin values (<jats:italic>r<\/jats:italic>=\u22120.44;<jats:italic>P<\/jats:italic>&lt;0.001). Bone turnover markers were significantly correlated with PTH, but not with sclerostin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with PHPT have significantly lower serum sclerostin values compared with PTx controls with normal PTH concentrations. The negative correlation between PTH and sclerostin suggests that<jats:italic>SOST<\/jats:italic>is downregulated by PTH in humans.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-10-0699","type":"journal-article","created":{"date-parts":[[2010,9,4]],"date-time":"2010-09-04T02:13:08Z","timestamp":1283566388000},"page":"833-837","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":87,"title":["Patients with primary hyperparathyroidism have lower circulating sclerostin levels than euparathyroid controls"],"prefix":"10.1093","volume":"163","author":[{"given":"A H","family":"van Lierop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Witteveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N A T","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S 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