{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:35:17Z","timestamp":1788842117184,"version":"build-2803163510"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We hypothesized that with the administration of teriparatide (TPTD) treatment at different times, we would be able to modify the physiological circadian rhythm of bone turnover.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The concentration of serum C-terminal telopeptide of collagen type I (\u03b2CTX), serum N-terminal propeptide of procollagen type I (P1NP), serum ionized calcium (iCa), and plasma PTH were measured every 3\u200ah over a 24\u200ah period in 14 postmenopausal osteoporotic women (aged 72.4\u00b19.3 years) treated with 20\u200a\u03bcg TPTD for long term, given at different times of the day. General linear model-repeated measurements (GLM RM) were performed to analyze the circadian rhythms as well as intergroup comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GLM-RM for both related groups showed a significant influence of time of day on all measured variables except P1NP. The analysis for each group separately provided a powerful model for \u03b2CTX (<jats:italic>P<\/jats:italic>&lt;0.001, <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>=0.496), serum iCa (<jats:italic>P<\/jats:italic>&lt;0.001, <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>=0.423), plasma PTH (<jats:italic>P<\/jats:italic>&lt;0.001, <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>=0.283), and serum PINP (<jats:italic>P<\/jats:italic>&lt;0.001, <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>=0.248). While the evening TPTD treatment showed a marked circadian rhythm for serum \u03b2CTX, the morning TPTD treatment rather suggested circasemidian rhythm. The P1NP rhythm followed a much smaller amplitude of the rhythm than \u03b2CTX. Changes in serum iCa were positively related to changes in serum \u03b2CTX (<jats:italic>P<\/jats:italic>&lt;0.001) and negatively related to changes in PTH (<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Timing of TPTD administration may significantly change the 24\u200ah variation in bone turnover markers as well as calcium-parathyroid axis in postmenopausal osteoporotic women.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-10-1108","type":"journal-article","created":{"date-parts":[[2011,2,3]],"date-time":"2011-02-03T04:03:35Z","timestamp":1296705815000},"page":"643-648","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":43,"title":["The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis"],"prefix":"10.1093","volume":"164","author":[{"given":"Maria","family":"Luchavova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit","family":"Zikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Michalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Raska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ales A","family":"Kubena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J","family":"Stepan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/164\/4\/643.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/164\/4\/643.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:26:13Z","timestamp":1676391973000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/164\/4\/643\/6677026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/eje-10-1108","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}