{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:10:19Z","timestamp":1789679419228,"version":"4.0.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Few population-based studies have described the epidemiology of subtypes of hyperthyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective population-based study, monitoring two well-defined Danish cohorts in Aalborg with moderate iodine deficiency (<jats:italic>n<\/jats:italic>=311\u200a102) and Copenhagen with only mild iodine deficiency (<jats:italic>n<\/jats:italic>=227\u200a632).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A laboratory monitoring system identified subjects with thyroid function tests suggesting overt hyperthyroidism (low s-TSH combined with high s-thyroxine or s-triiodothyronine). For all subjects, we collected information on medical history, thyroid scintigraphy and thyroid hormone receptor antibody (TRAb) measurement. Information was used to disprove or verify primary overt hyperthyroidism and to subclassify hyperthyroidism into nosological disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1997 to 2000 (2\u200a027\u200a208 person-years of observation), we verified 1682 new cases of overt hyperthyroidism. The overall standardized incidence rate (SIR) per 100\u200a000 person-years was 81.6, and was higher in Aalborg compared with Copenhagen (96.7 vs 60.0,<jats:italic>P<\/jats:italic>&lt;0.001), giving an SIR ratio (SIRR (95% confidence interval (CI))) between moderate versus mild iodine-deficient areas of 1.6 (1.4\u20131.8). Nosological types of hyperthyroidism (percentage\/SIRR (95% CI)): multinodular toxic goitre (MNTG) 44.1%\/1.9 (1.6\u20132.2), Graves' disease (GD) 37.6%\/1.2 (0.99\u20131.4), solitary toxic adenoma (STA) 5.7%\/2.4 (1.3\u20133.5), \u2018mixed type\u2019 hyperthyroidism (TRAb-positive, scintigraphicly multinodular) 5.4%\/6.0 (3.0\u201312), subacute thyroiditis 2.3%\/0.9 (0.4\u20131.4),<jats:italic>postpartum<\/jats:italic>thyroid dysfunction 2.2%\/1.6 (0.8\u20133.0), amiodarone-associated hyperthyroidism 0.8%\/7.1 (1.1\u201365), hyperthyroidism after thyroid radiation 0.7%\/12.3 (0.8\u201350), lithium-associated hyperthyroidism 0.7%\/0.97 (0.4\u20134.8) and hyperthyroidism caused by various other factors 0.7%. Lifetime risk for overt hyperthyroidism was 10.5%\/6.5%\/2.4% (females\/all\/males).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyperthyroidism was common in Denmark with MNTG and GD as dominating entities. The higher incidence of hyperthyroidism in the most iodine-deficient region was caused by higher frequency of MNTG, \u2018mixed-type\u2019, STA and amiodarone-associated hyperthyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-10-1155","type":"journal-article","created":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T21:51:58Z","timestamp":1299016318000},"page":"801-809","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":174,"title":["Epidemiology of subtypes of hyperthyroidism in Denmark: a population-based study"],"prefix":"10.1093","volume":"164","author":[{"given":"Allan","family":"Carl\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge B\u00fclow","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Perrild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ovesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Banke","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Laurberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"4","key":"1_6487881","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archinte.160.4.526","volume":"160","author":"Canaris","year":"2000","journal-title":"Archives of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"issue":"1","key":"2_15973357","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","volume":"43","author":"Vanderpump","year":"1995","journal-title":"Clinical endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0300-0664","issn-type":"print"},{"issue":"5","key":"3_9469270","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2796.1991.tb00368.x","volume":"229","author":"Laurberg","year":"1991","journal-title":"Journal of internal medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0954-6820","issn-type":"print"},{"issue":"1","key":"4_10734487","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/thy.1999.9.33","volume":"9","author":"Laurberg","year":"1999","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"5","key":"5_15874534","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1530\/eje.0.1320546","volume":"132","author":"Baltisberger","year":"1995","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"4","key":"6_5975317","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s002590050234","volume":"25","author":"Mostbeck","year":"1998","journal-title":"European journal of nuclear medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6997","issn-type":"print"},{"key":"7_38643668","first-page":"49","volume":"6","year":"1994","journal-title":"Thyroidology \/ A.P.R.I.M"},{"issue":"6","key":"8_31121003","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1530\/EJE-07-0877","volume":"158","author":"Abraham-Nordling","year":"2008","journal-title":"European Journal of Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"issue":"3","key":"9_9098780","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1136\/jech.37.3.245","volume":"37","author":"Williams","year":"1983","journal-title":"Journal of Epidemiology &amp; 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