{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:00:32Z","timestamp":1792166432654,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Low plasma triiodothyronine (T<jats:sub>3<\/jats:sub>) levels are considered a prognostic predictor of death in heart failure (HF) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study an association between plasma T<jats:sub>3<\/jats:sub> levels and several cardiac, neurohormonal, and metabolic markers of HF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 133 ambulatory HF patients (114 males; mean age 63.2 years) with left ventricular ejection fraction &lt;40% were enrolled. TSH, total tetraiodothyronine (T<jats:sub>4<\/jats:sub>) and T<jats:sub>3<\/jats:sub>, N-terminal pro-brain natriuretic peptide (NT-proBNP), and other cardiac and metabolic parameters were measured. The lowest tertile of T<jats:sub>3<\/jats:sub> (group 1) was compared against the two upper ones (group 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In simple logistic regression, the lowest T<jats:sub>3<\/jats:sub> tertile was associated with more advanced HF disease status: older (age: odds ratio (OR)=1.05; confidence interval (CI) 95% 1.01\u20131.09, <jats:italic>P<\/jats:italic>=0.004), lower functional capacity (walking test: OR=0.996; CI 95% 0.993\u20130.999, <jats:italic>P<\/jats:italic>=0.008), higher NT-proBNP (OR=1.64; CI 95% 1.19\u20132.27, <jats:italic>P<\/jats:italic>=0.003) and adiponectin levels (OR=1.07; CI 95% 1.02\u20131.11, <jats:italic>P<\/jats:italic>=0.004), lower DHEAS log-transformed (OR=0.50; CI 95% 0.31\u20130.80, <jats:italic>P<\/jats:italic>=0.004), and the presence of lower phase angle values as measured by body bioelectrical impedance analysis (OR=3.18; CI 95% 1.50\u20136.71, <jats:italic>P<\/jats:italic>=0.04) and worse renal function (OR=0.96; CI 95% 0.94\u20130.98, <jats:italic>P<\/jats:italic>=0.003). T<jats:sub>3<\/jats:sub> levels in the lowest tertile were independently associated with low phase angle values (OR=2.95, CI 95% 1.16\u20137.50, <jats:italic>P<\/jats:italic>=0.02) and the log transformation of DHEAS (OR=0.56; CI 95% 0.32\u20130.97, <jats:italic>P<\/jats:italic>=0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have demonstrated an association between plasma T<jats:sub>3<\/jats:sub> levels in the lower range and other deranged hormonal and metabolic parameters in HF patients.<\/jats:p><\/jats:sec>","DOI":"10.1530\/eje-11-0094","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T04:02:14Z","timestamp":1301630534000},"page":"937-942","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":11,"title":["Low plasma triiodothyronine levels in heart failure are associated with a reduced anabolic state and membrane damage"],"prefix":"10.1093","volume":"164","author":[{"given":"Gabriela","family":"Brenta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Thierer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Vainstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Brites","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Boero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"G\u00f3mez Rosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Anker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/164\/6\/937.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/164\/6\/937.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:26:28Z","timestamp":1676391988000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/164\/6\/937\/6676871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1530\/eje-11-0094","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}