{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:44:28Z","timestamp":1790484268926,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the tolerability and efficacy of sorafenib in patients with thyroid carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with progressive locally advanced\/metastatic medullary thyroid carcinoma (MTC), or differentiated thyroid carcinoma (DTC) with non-radioiodine-avid disease, were treated with sorafenib 400\u200amg twice daily until disease progression. The primary endpoint was the radiological response rate (RR) at 6 months. Secondary endpoints were RR at 3, 9 and 12 months, biochemical responses, toxicity, biomarker analyses and progression free and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 34 patients were recruited to the study (15 medullary and 19 differentiated). After 6 months, the RR rate was 15% and a further 74% of patients achieved stable disease in the first 6 months. After 12 months of treatment, the RR was 21%. In the MTC patients, the RR at 12 months was 25% and OS was 100%. In DTC patients corresponding rates were 18 and 79% respectively. Median overall and progression-free survival points were not reached at 19 months. Commonest adverse events included hand\u2013foot syndrome, other skin toxicities, diarrhoea and alopecia. Dose reduction was required in 79% patients. Median time on treatment was 16.5 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that sorafenib is tolerable at reduced doses over prolonged periods of time in patients with thyroid cancer. Sorafenib leads to radiological and biochemical stabilisation of disease in the majority of these patients despite dose reductions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/eje-11-0129","type":"journal-article","created":{"date-parts":[[2011,5,13]],"date-time":"2011-05-13T20:13:24Z","timestamp":1305317604000},"page":"315-322","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":160,"title":["Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based population"],"prefix":"10.1093","volume":"165","author":[{"given":"Merina","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Barbachano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Riddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaya","family":"Viros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Marais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Nutting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"1","key":"1_18631236","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/canjclin.55.1.10","volume":"55","author":"Jemal","year":"2005","journal-title":"CA: A Cancer Journal for Clinicians","ISSN":"https:\/\/id.crossref.org\/issn\/0007-9235","issn-type":"print"},{"issue":"7","key":"3_10885133","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1210\/jc.84.7.2291","volume":"84","author":"Wang","year":"1999","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"5","key":"4_10848769","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/thy.1999.9.421","volume":"9","author":"Mazzaferri","year":"1999","journal-title":"Thyroid : official journal of the American Thyroid Association","ISSN":"https:\/\/id.crossref.org\/issn\/1050-7256","issn-type":"print"},{"issue":"2","key":"5_11185980","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1677\/erc.0.0080135","volume":"8","author":"Orlandi","year":"2001","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"4","key":"6_5420465","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/bjc.1989.316","volume":"60","author":"Wright","year":"1989","journal-title":"British Journal of Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1532-1827","issn-type":"print"},{"issue":"2","key":"7_18913044","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1677\/erc.1.0978","volume":"12","author":"Xing","year":"2005","journal-title":"Endocrine-Related Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1351-0088","issn-type":"print"},{"issue":"10","key":"8_18865559","doi-asserted-by":"publisher","first-page":"4238","DOI":"10.1158\/0008-5472.CAN-05-0047","volume":"65","author":"Knauf","year":"2005","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"6","key":"9_17660055","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/jc.2002-021186","volume":"88","author":"Vasko","year":"2003","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"6428","key":"10_10248353","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/363458a0","volume":"363","author":"Mulligan","year":"1993","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"3","key":"11_6455034","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","volume":"92","author":"Therasse","year":"2000","journal-title":"JNCI Journal of the National Cancer Institute","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"issue":"5","key":"12_22559256","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/sj.bjc.6603291","volume":"95","author":"Eisen","year":"2006","journal-title":"British Journal of Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/1532-1827","issn-type":"print"},{"issue":"6","key":"13_11072737","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1002\/sim.721","volume":"20","author":"A'Hern","year":"2001","journal-title":"Statistics in medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0277-6715","issn-type":"print"},{"issue":"10","key":"14_34179945","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1200\/JCO.2008.18.2717","volume":"27","year":"2009","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"29","key":"15_31267949","doi-asserted-by":"publisher","first-page":"4714","DOI":"10.1200\/JCO.2008.16.3279","volume":"26","year":"2008","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"29","key":"16_31267943","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1200\/JCO.2007.15.9566","volume":"26","year":"2008","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"1","key":"17_31370171","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1056\/NEJMoa075853","volume":"359","author":"Sherman","year":"2008","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"14","key":"18_37035348","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1200\/JCO.2009.25.0068","volume":"28","year":"2010","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"17","key":"19_34524212","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1200\/JCO.2007.15.7636","volume":"27","year":"2009","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"6892","key":"20_17120961","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nature00766","volume":"417","author":"Davies","year":"2002","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"21_40308776","first-page":"5","volume":"7","year":"2009","journal-title":"EUROPEAN JOURNAL OF CANCER SUPPLEMENTS"},{"issue":"22","key":"22_18520393","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.1200\/JCO.2004.07.960","volume":"22","year":"2004","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"key":"23_40308777","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4161\/cbt.7.4.5624","volume":"7","year":"2008","journal-title":"CANCER BIOLOGY THERAPY"},{"key":"24_35191228","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1556::AID-CNCR20>3.0.CO;2-Y","volume":"77","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/1097-0142","issn-type":"print"},{"issue":"11","key":"25_19578245","doi-asserted-by":"publisher","first-page":"6077","DOI":"10.1210\/jc.2005-0044","volume":"90","year":"2005","journal-title":"Journal of Clinical Endocrinology &amp; Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"8","key":"26_33673341","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1200\/JCO.2008.19.3342","volume":"27","year":"2009","journal-title":"Journal of Clinical Oncology","ISSN":"https:\/\/id.crossref.org\/issn\/0732-183X","issn-type":"print"},{"issue":"14","key":"27_29043851","doi-asserted-by":"publisher","first-page":"6956","DOI":"10.1158\/0008-5472.CAN-06-4605","volume":"67","author":"Akeno-Stuart","year":"2007","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"4","key":"28_31543255","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJMoa0708857","volume":"359","author":"Llovet","year":"2008","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/165\/2\/315.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/165\/2\/315.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T11:26:30Z","timestamp":1676373990000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/165\/2\/315\/6676799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":27,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/eje-11-0129","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.720334770.793503109","asserted-by":"object"}]},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}